Los Angeles Dodgers vs Arizona Diamondbacks Prediction and Picks - September 23, 2025

Major League Baseball action on Tuesday evening, and we have a Los Angeles Dodgers vs Arizona Diamondbacks Prediction ready to rock and roll. Los Angeles has had another solid season as they are 88-68 on the year and lead the National League West by three games over the Padres. Arizona still has hopes of a playoff berth as they come in just one game out of the 3rd wildcard slot with a 79-77 record. Can the Diamondbacks keep their playoff hopes alive? Read on to see our Dodgers vs Diamondbacks prediction.

Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.

Dodgers Had 4-Game Win Streak Snapped

The Dodgers enter Tuesday’s series opener looking to rebound from a frustrating 3–1 loss to the Giants on Sunday, a game that unraveled in the eighth inning after reliever Blake Treinen surrendered three runs on three hits and two walks. The defeat snapped a four-game win streak and wasted a brilliant outing from Emmet Sheehan, who tossed seven innings of one-hit ball with 10 strikeouts and no walks. Michael Conforto drove in the lone run for Los Angeles, but the offense stalled late, and the bullpen’s recent struggles resurfaced at a critical moment. Despite the setback, the Dodgers remain in control of the NL West with a record of 88–68 and a magic number of 3 to clinch the division.

Los Angeles now shifts to Phoenix for a three-game set against a surging Diamondbacks squad that’s fighting for a Wild Card berth. The Dodgers have won 57% of their games as favorites this season and have gone 6–4 over their last 10. Shohei Ohtani continues to be the centerpiece of the offense, riding a nine-game hitting streak and leading the team with 53 home runs and 99 RBIs. Freddie Freeman (.292 AVG) and Mookie Betts (.258 AVG) round out a lineup that ranks second in MLB in slugging (.440) and runs scored (794). The Dodgers have also drawn over 4 million fans this season, a testament to their sustained excellence and star power. With the postseason looming, every inning now serves as a tune-up for October.

Shohei Ohtani will make his final regular-season start on the mound, entering with a 1–1 record and a 3.29 ERA over 41.2 innings. He’s struck out 54 batters and held opponents to a .227 average, though he’s yet to record a quality start this season. In his last outing, Ohtani threw five hitless innings against the Phillies, showcasing elite swing-and-miss stuff and improved command. The Dodgers will be looking for length and efficiency from Ohtani, especially with the bullpen in flux. Against a Diamondbacks lineup that ranks top five in slugging and runs per game, Ohtani’s ability to manage traffic and avoid the big inning will be crucial.

D-Backs Look To Keep Playoff Hopes Alive

The Diamondbacks come into Tuesday’s matchup riding a wave of momentum after a dominant 9–2 win over the Phillies on Sunday. Corbin Carroll led the charge with a four-RBI performance, including a three-run homer in the second inning and a stolen base that made him the first player in franchise history to record 30 homers and 30 steals in a season. Eduardo Rodriguez pitched six scoreless innings, scattering six hits and striking out five. Arizona’s offense exploded for 15 hits, including solo shots from Jorge Barrosa and Tim Tawa, and the team has now won six of its last eight games. At 79–77, the Diamondbacks are just one game back of the final NL Wild Card spot and very much alive in the playoff race.

Arizona has been one of the most dangerous lineups in the league over the past month, ranking fourth in MLB in runs scored (773) and third in slugging (.435). Geraldo Perdomo (.290 AVG, 97 RBIs) continues to be a catalyst at the top of the order, while Carroll’s power-speed combo and Ketel Marte’s consistency (.280 AVG, 26 HRs) give the Diamondbacks multiple ways to pressure opposing pitchers. The team has also tightened up defensively, committing zero errors in Sunday’s win and improving its fielding percentage to .986. With the Dodgers in town and postseason stakes on the line, expect Arizona to play with urgency and aggression from the first pitch.

Brandon Pfaadt will take the mound for Arizona, entering with a 13–8 record and a 5.02 ERA over 166.2 innings. He’s coming off a gem against the Giants, where he threw nine scoreless innings and allowed just one hit. Pfaadt has 11 quality starts this season and has pitched five or more innings in 23 of his 31 outings. While his ERA is elevated, he’s shown flashes of dominance, especially when he’s able to command his fastball and keep hitters off balance with his slider. Against a Dodgers lineup that ranks second in home runs (232) and slugging, Pfaadt’s ability to limit hard contact and avoid walks will be key to keeping Arizona in the game.

Los Angeles Dodgers vs Arizona Diamondbacks Pick

Dodgers vs Diamondbacks Moneyline Pick

• Arizona +130 (4 Units)

Backing the Diamondbacks as a home underdog (+130) against the Dodgers offers strong value, especially considering Arizona’s recent form and urgency. They’ve won six of their last eight and are coming off a 9–2 dismantling of the Phillies, with Corbin Carroll and Ketel Marte leading a lineup that’s been explosive in September. Brandon Pfaadt, while inconsistent, is coming off a one-hit shutout against the Giants and has shown he can rise to the occasion. Arizona has also played the Dodgers tight all season, winning four of their last seven head-to-head matchups and covering the runline in five of those games.

The Dodgers, meanwhile, are laying heavy chalk (-154) behind Shohei Ohtani, who’s yet to record a quality start this season despite flashes of dominance. Their bullpen has been shaky, and they’re coming off a late-inning collapse against the Giants. With the Diamondbacks fighting for a Wild Card spot and playing at home, the motivational edge is clear. Arizona’s speed, defensive sharpness, and recent offensive surge make them a live dog in this spot—especially if Pfaadt can keep the ball in the yard and force the Dodgers to string hits together.

Dodgers vs Diamondbacks Over/Under Pick

• Under 9 (5 Units)

The Under 9 looks like a sharp angle in Tuesday’s Dodgers–Diamondbacks matchup, especially with Shohei Ohtani and Brandon Pfaadt on the mound. Ohtani has allowed two earned runs or fewer in six of his 13 starts this season and is coming off five hitless innings against the Phillies. While he hasn’t gone deep into games, his swing-and-miss stuff and ability to suppress hard contact have kept scoring low early. On the other side, Pfaadt is fresh off a one-hit shutout against the Giants and has shown improved command over his last few outings. Both pitchers are capable of controlling the tempo, and with playoff stakes in play, expect a tighter, more deliberate approach from both dugouts.

Offensively, the Dodgers and Diamondbacks have firepower, but recent trends suggest a lower-scoring affair. Los Angeles has hit the Under in five of its last nine games, and Arizona has stayed below the total in four of its last six. The Dodgers’ bullpen, despite some volatility, has held opponents to a .218 average over the past week, while Arizona’s relief corps has quietly posted a sub-3.00 ERA in September. With a total set at 9 and both teams likely to lean on their top arms, the Under offers value—especially if Ohtani and Pfaadt can avoid early damage and keep the ball in the yard.