Los Angeles Dodgers vs. San Francisco Giants Picks and Prediction, Saturday, September 13, 2025 

By: Michael Briggs Published 09/13/2025, 05:16 AM ET
Giants vs Reds prediction
Use Code WWWC

On Thursday, the San Francisco Giants will host the Los Angeles Dodgers at Oracle Park, and we have you ready to go with our Dodgers vs. Giants prediction. First pitch is at 6:05 p.m. PT.

Los Angeles is a -125 moneyline favorite, and the game total is 7.5 runs scored.

This is the third series of the season between SF and LA. The Dodgers are 7-3 in their last ten meetings with the Giants, and the over was 5-4-1 in those ten games. If you want the Dodgers vs. Giants prediction, read on and check out our MLB Predictions to beat the sportsbooks!

*Article published before the conclusion of Friday night's game.

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

Kershaw is having a resurgent season

Los Angeles (82-64 SU, 63-83 RL, and 67-72-7 O/U) swept Colorado in its previous series. The Dodgers are 5-5 in their last ten games (the under went 5-3-2).

LA will start left-hander Clayton Kershaw on Saturday against San Francisco. In his last outing, the 37-year-old allowed two runs on four hits with eight strikeouts in a 5.2-inning win vs. Baltimore. He is 10-2 with a 3.27 ERA and 1.16 WHIP in 19 starts (99.0 IP) this year, including 5-2 with a 3.18 ERA and 1.14 WHIP in ten road starts (51.0 IP).

The Dodgers are fresh off a World Series title with the biggest payroll in baseball, but with a 24-25 record in the second half, they are in a tight race to win the NL West. Los Angeles has all the talent in the world, but making it back to the top of the mountain will still be a challenge. Can they hold off San Diego in the division title race?

Los Angeles Dodgers Baseball Injury Report: No new injuries to report for tomorrow's game against the Giants.

San Francisco is back in the Wild Card race

San Francisco (74-72 SU, 67-69 RL, and 69-71-6 O/U) won two of three games against Arizona in its previous series. The Giants are 7-3 in their last ten games (the over was 6-4).

SF will turn to right-hander Logan Webb on Saturday against Los Angeles. In his last outing (6.0 IP win against the D-Backs), the 28-year-old surrendered four runs (one earned) on five hits, fanning seven batters. He is 14-9 with a 3.12 ERA and 1.22 WHIP in 30 appearances (184.2 IP) this season, including 7-3 with a 2.77 ERA and 1.16 WHIP in 16 appearances (100.2 IP) at home.

The Giants don't have the notoriety of their National League West division rivals, but they have been competitive in the NL West this season, especially recently, winning five of their last six series. San Francisco is still eight games back of LA in the division, but is only 1.5 games out of the NL Wild Card race. Can they finish strong to make the playoffs?

San Francisco Giants Injury Report: No injuries for tomorrow's game against the Dodgers.

Dodgers vs. Giants Pick

Moneyline Pick for Dodgers vs. Giants

  • Dodgers ML (5 Units)

Kershaw has fared well against SF, holding current Giants hitters to a .188 BA and .223 wOBA in 127 plate appearances. He boasts a 2.00 career ERA against San Francisco (61 appearances). The Giants have also struggled against left-handed pitchers this season, ranking 30th in wOBA, 28th in K/BB ratio, and 26th in wRC+. Webb hasn't been as successful versus LA, as the current Dodgers lineup boasts a .307 BA and .379 wOBA in 275 previous plate appearances. He is 6-6 with a 4.33 ERA in  18 career appearances vs. Los Angeles.

Over/Under Pick for Dodgers vs. Giants

  • Over 7.5 (4 Units)

Betting Trend: The over is 22-16-1 in San Francisco's division games this season, third-highest in MLB.

I respect Kershaw, but the Dodgers' bullpen has been shaky. The unit has a 4.19 ERA (19th) and has allowed 72 homers this season. They have been especially ineffective recently, ranking 22nd in ERA and xERA in the last two weeks. With Los Angeles expected to score a few early runs against Webb, I lean towards the over at 7.5.

Never Tried Winners and Whiners? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code DOLLAR
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
  • Check out more MLB predictions
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright © 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.