Los Angeles Dodgers vs. Seattle Mariners Picks and Prediction for Friday, September 26th, 2025

By: Adam Rauzino Published 09/26/2025, 10:37 AM ET
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The Los Angeles Dodgers (90-69, 68-90 RL, 73-77-9 O/U) and the Seattle Mariners (89-69, 70-88 RL, 87-65-5 O/U) begin a three-game series on Friday evening, and we have you covered with the prediction. The Dodgers are going with Emmet Sheehan. The Mariners will answer with George Kirby. The Dodgers swept the Mariners in the previous series between these squads last season.

Can the Mariners continue their dominance with another home win to begin the series? Check out the Dodgers vs. Mariners prediction. Nobody does it better when it comes to MLB Picks!

Sheehan on the Mound to Begin Series

Emmet Sheehan will get the nod on Friday. Sheehan was dominant in his recent effort last week, posting seven scoreless innings against San Francisco, and had no help from the offense, ending in a no-decision in a game the Dodgers lost. The righty has been outstanding, conceding two or fewer runs in five straight outings and has delivered a 2.86 ERA and a 0.97 WHIP accompanied by a 6-3 record in 72.1 innings on the year. Sheehan issued three scoreless innings in his only career meeting against Seattle.

The Los Angeles Dodgers are on the road to end the season and are awaiting to see their opponent for the wildcard series next week. L.A. has secured the NL West yet again. They won a home series against the Giants last week and posted one win in the opening two games against the Diamondbacks this week, entering Thursday evening. The squad is 37-40 on the road.

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Shohei Ohtani has a dazzling 1.1 OPS this month. The star slugger has 53 bombs with 99 RBIs and a 1.01 OPS. Max Muncy has posted a .562 OPS in September. The veteran has recorded 67 RBIs on the year. Teoscar Hernandez has managed five RBIs in his past five games. The 32-year-old has netted 89 RBIs and a .742 OPS. Mookie Betts has been outstanding, amassing 21 RBIs this month. The veteran shortstop now has 20 home runs and 80 RBI this season.

Los Angeles is averaging 5.09 runs per game, good for second. The pitching staff has a mediocre 4.02 ERA, placing them 16th.

Mariners Secure First Place in the AL West

George Kirby is expected be on the rubber to begin the series on Friday. Kirby was on his game this past weekend, posting six scoreless innings against Houston, and was credited with the win. The veteran needed that one as he has been struggling recently, posting an ERA of nearly six this month. Kirby is having a decent season, sporting a mediocre 4.24 ERA and a 1.21 WHIP, accompanied by a 10-7 record in 121 innings of work. He squandered four runs in six innings in his only meeting against the Dodgers.

The Seattle Mariners have been dominant this month and have won the AL West ahead of the Astros. The Mariners issued a huge road sweep of the Astros last weekend. Next, they won the first two games of their home series against the Rockies, entering Thursday, aided by the pitching, conceding only five runs. They are the #2 seed in the AL standings and will have a bye in the wildcard if they can finish ahead of the Guardians or Tigers. The Mariners have posted a 50-27 mark at home.

Cal Raleigh is having a historic season. The star catcher has bashed 60 home runs wth 125 RBIs and a sharp .959 OPS, making him an MVP candidate. Jorge Polanco has also been a threat, netting a sparkling .960 OPS in September. The veteran second baseman has posted 75 RBIs. Julio Rodriguez has netted 17 RBIs in September. The star center fielder has 32 bombs with 95 RBIs. Randy Arozarena has been quiet, posting just one RBI in his last 10 games. The veteran outfielder has generated 74 RBIs and a strong .755 OPS on the season.

Seattle is posting an average of 4.71 runs on the season, marking them ninth. The pitching is strong, reporting a 3.88 ERA, placing them 11th.

Dodgers vs. Mariners Pick

Spread Pick for Dodgers vs. Mariners

  • Seattle Mariners ML (5 units)

The Los Angeles Dodgers are just one game away from securing the NL West entering Thursday evening, and are expected to be the #3 seed in the NL. The Seattle Mariners have been the best team in the big leagues this month. They have only dropped five games the entire month. The Mariners have won 10 straight home games. These games have big meaning for the Mariners as they are striving for the #1 seed in the AL, which secures home field in the ALDS and ALCS.

Furthermore, Dodgers pitcher Emmet Sheehan has been sharp but is not the same pitcher on the road, where he has a subpar 4.40 ERA on the year. The Dodgers are 0-2 in his last two outings. Mariners pitcher George Kirby rebounded with a strong outing last week, pitching six scoreless innings against the Astros. The Mariners have won in each of Kirby's past three outings. He has netted a strong 3.36 ERA at home. The Mariners have kept their opponent to just 12 runs in their past five games.

Over/Under Pick for Dodgers vs. Mariners

  • Over (5 units)

I expect plenty of runs. Los Angeles continues to generate a ton of runs. They have averaged 5.5 runs in their past 10 games. Kirby has been shaky, as seen in his ERA near six this month.

In addition, Seattle has been raking at the dish. They have scored five or more runs in seven of their past 10 games. Sheehan isn't pitching deep into games, going 5.2 or fewer innings in six of his past ten outings, and the Dodgers' bullpen is a bit of a weakness, posting a 4.25 ERA on the season. The over is a convincing 7-3 in the Mariners' past 10 games.

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