Los Angeles Dodgers vs Seattle Mariners Prediction and Picks - September, 28, 2025

By: Mike Fink Published 09/28/2025, 01:24 AM ET
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The Los Angeles Dodgers face the Seattle Mariners, with both teams wrapping up excellent seasons and preparing for the postseason. The Dodgers are 91-69 and with the best record in the National League West Division secured, they will be the three seed in the National League. The Mariners are 90-70 and not only clinched the American League East Division, but they also secured a bye to the divisional round. Who will win this game? Check out our Dodgers vs Mariners prediction!

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Dodgers hope lineup helps out Kershaw in his final regular-season start

The Dodgers are having a great season and are set up for success in the postseason. Clayton Kershaw will make his final regular-season start of his Hall of Fame career and looks to put a bow on a great career and a season where he’s allowed only 46 runs in 107 innings pitched while tossing 77 strikeouts. Moreover, with a .395 expected opponent Slugging Percentage, a 4.3 Barrel Percentage, and a 3.92 expected ERA, opponents are making weak contact and struggling to drive in runs against Kershaw this season.

Kershaw is having a great season, while the lineup has stepped up as well, scoring 5.09 runs per game. Shohei Ohtani is slashing .279/.390/.616 with 54 home runs and 373 total bases, while Will Smith is slashing .296/.404/.497 with 17 home runs and 180 total bases, but the rest of the lineup has stepped up as well. Freddie Freeman is slashing .293/.364/.496 with 23 home runs and 274 total bases, while Andy Pages and Max Muncy have added 46 home runs and 414 total bases to round out the lineup.

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Seattle hopes lineup helps out Miller this season

The Mariners won the division for the first time since 2001 and now look to win the World Series for the first time in franchise history. Bryce Miller will start the upcoming game, and he looks to end a rough season strong as he’s allowing 53 runs in 86 innings pitched. Additionally, with a .287 expected opponent Batting Average, a .478 expected opponent Slugging Percentage, and a 5.33 expected ERA, opponents are making contact and powering the ball to easily plate baserunners.

Miller has struggled, but the lineup has propelled them to the postseason, scoring 4.76 runs per game with 17 runs in the last three games. Cal Raleigh is slashing .248/.360/.594 with 60 home runs and 350 total bases as the AL MVP frontrunner, while Dominic Canzone is slashing .304/.360/.488 with 11 home runs and 117 total bases, but the rest of the lineup has stepped up as well. Josh Naylor is slashing .299/.341/.490 with nine home runs and 90 total bases, while Julio Rodriguez and Jorge Polanco have added 57 home runs and 537 total bases to round out the lineup, making the Mariners tough to put away at the plate.

Dodgers vs Mariners Prediction

Money Line Pick for Dodgers vs. Mariners

  • Mariners (-105) (4 Units)

Both teams are locked into their postseason spots but the Mariners look to secure this one at home as Cal Raleigh chases down the American League home run record. The Mariners, who average 4.76 runs per game, should drive in runs at will with Cal Releigh, Josh Naylor, and the rest of the batting order making contact and putting together strong plate appearances to easily plate baserunners. The Mariners should limit the Dodgers' lineup with Bryce Miller tossing multiple strong innings to hand the ball over to the bullpen with the lead. The Mariners should win the game with a strong performance at home.

Take the Mariners money line as home Favorites.

Over/Under Pick for Dodgers vs. Mariners

  • Over 8 (5 Units)

Both teams have great lineups, and this game looks to be a high-scoring one from the first pitch. The Dodgers, who average 5.09 runs per game, should constantly plate baserunners with Shohei Ohtani, Will Smith, and the rest of the batting order making contact and putting together strong plate appearances. The Mariners, who have scored 17 runs in the last three games, should run up the score with Cal Raleigh, Josh Naylor, Jorge Polanco, and the rest of the batting order swinging for the fences and crushing pitches to circle the bases at will. The Over should cover in a high-scoring game with both batting orders stepping up.

Take the Over on 8 runs.

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