Miami Marlins vs. Colorado Rockies Picks and Prediction, Wednesday, September 17, 2025
Use Code WWWC On Wednesday, the Miami Marlins will play the Colorado Rockies at Coors Field, and we have you ready to go with our Marlins vs. Rockies prediction. First pitch from Denver is at 8:40 p.m. ET.
The Marlins are -155 moneyline favorites, and the game total is 10.5 runs scored.
Colorado swept Miami in a three-game set earlier this season. The ballclubs have split their last ten meetings, and the over/under was also split 5-5 in those ten games. If you want the Marlins vs. Rockies prediction, read on and check out our MLB Predictions to beat the sportsbooks!
Miami has been more competitive in the second half
Miami (70-80 SU, 85-65 RL, and 75-70-5 O/U) won two of three games against Detroit in their previous series. The Marlins were 5-5 in their last ten games (the over was 6-3-1).
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Miami will turn to left-hander Ryan Weathers tomorrow against Colorado. In his last outing, the 25-year-old gave up five hits and no runs in a five-frame win against Washington. He is 2-1 with a 2.73 ERA and 1.04 WHIP in six starts (29.2 IP) this year, including 1-0 with a 2.63 ERA and 0.95 WHIP in three road starts (13.2 IP).
The Marlins may not be on anyone's radar to make the postseason, but the ballclub has made significant strides in 2025. Miami has experienced its share of success this season, particularly on offense. The Fins are scoring 4.5 runs per game in the second half of the season, and have been more competitive than in the first half (26-29 record). Can they finish on a high note?
Miami Marlins Baseball Injury Report: No injuries to report for Wednesday's game versus the Rockies.
Rockies are limping to the finish line
Colorado (41-109 SU, 61-89 RL, and 65-80-5 O/U) lost three of four games to San Diego in its previous series. The Rockies are 2-8 in their last ten games (the under was 5-4-1).
Colorado will turn to righty McCade Brown tomorrow against Miami. The 25-year-old has only made four MLB appearances, pitching to a 0-4 record with a 9.88 ERA and 2.12 WHIP in 13.2 combined innings. The 2021 third-round pick out of Indiana was 4-2 with a 2.47 ERA and 1.07 WHIP in 20 combined minor league appearances (76.2 IP) at the A+ and AA levels.
The Rockies have failed to be more competitive this season, trailing the first-place Dodgers by 43 games in the NL West division standings. They're also 34 games behind the fourth-place Diamondbacks. It's been tough for Rockies hitters to make an impact on the game's outcome, as the pitching staff has a 6.01 ERA, including 6.57 at home. While more competitive against the run line, Colorado is a team most bettors have steered clear of this season.
Colorado Rockies Baseball Injury Report: No injuries for Wednesday's game versus the Marlins.
Marlins vs. Rockies Pick
Run Line Pick for Marlins vs. Rockies
- Marlins Cover Run Line (4 Units)
Betting Trend: Colorado is 30-43 (41.1%) against the run line as home underdogs, the lowest winning percentage in MLB this season.
At nearly -160 odds, Miami is too expensive for my taste on the moneyline. Instead, I recommend a wager on the visitors to win by at least two runs tomorrow. Weathers has been mostly impressive in limited action this season and picked up where he left off on September 11 in his return from the IL. He should be able to limit a Rockies lineup ranked last in wRC+ with the fifth-highest strikeout percentage (24.8%) against left-handers. I also anticipate plenty of scoring from Miami's side, as Brown has been ineffective and the Marlins have been productive on the road this year (12th in wOBA and wRC+).
Over/Under Pick for Marlins vs. Rockies
- Over 10.5 (5 Units)
While Weathers has been solid this season, he has only appeared in one big league game since early June. He hasn't faced Colorado since 2023, but hasn't been too effective against them (8.44 ERA), and could struggle at hitter-friendly Coors Field. Brown hasn't inspired confidence in his first few MLB outings, either. The Marlins have been much more productive at the plate on the road, and they scored 4.9 runs per game last month. Given that these bullpens are also unreliable (21st and 29th in ERA), I lean towards the under in Wednesday's game.
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