Miami Marlins vs. Philadelphia Phillies Prediction, Tuesday, September 23, 2025

By: Mark Ruelle Published 09/23/2025, 11:35 AM ET
Marlins at Phillies MLB Prediction
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In this Marlins at Phillies prediction, the Marlins and Phillies meet in game one of their three-game series in Philadelphia on Tuesday night. The Marlins are just playing for pride at this point, ready to regroup for a playoff push next season. The Phillies have already clinched the NL East Division crown and are likely locked into the second seed in the NL Playoffs. The pitching matchup in game one of the series will feature Marlins’ righty Edward Cabrera (7-7, 3.57) taking on Phillies’ southpaw Cristopher Sanchez (13-5, 2.66). The first pitch is scheduled for 6:45 PM EST. Read on for more in this Marlins/Phillies prediction, and grab our top MLB predictions to increase your bankroll!

Marlins streaking to the finish

The Miami Marlins roll into Philadelphia riding a six-game winning streak. The streak has the team within four games of .500 with just six games left in the regular season. The Marlins swept through a road trip through Colorado and then Texas over the weekend. The weekend series in Arlington concluded with a 4-2 win over the Rangers. Shortstop Otto Lopez led the Marlins with three hits, including a run scored and an RBI, to pace the offense. The Marlins’ bullpen tightened up over the final three innings, not allowing a run or a hit to help the Marlins to victory.

The Marlins will send righty Edward Cabrera to the mound on Tuesday night in the series opener. Cabrera returned from the IL and was announced as the starter on Monday afternoon. He is 7-7 on the season in 24 starts, including seven quality starts. Cabrera has allowed 114 hits in 128.2 innings of work. He has an ERA of 3.57 and a WHIP of 1.21, while walking 42 and striking out 140 batters. The Marlins have won three of Cabrera’s last five starts. He is 2-4 on the road this season in 11 starts with an ERA of 4.47.

Key Injuries: LF Kyle Stowers is out.

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Phillies toasts of the East

The Philadelphia Phillies return home to close out the season after going 3-3 in a six-game road trip through Los Angeles and Arizona. The Phillies closed out the trip on Sunday with a 9-2 loss to the Diamondbacks, their third loss in four games. Alec Bohm reached base five times with four hits and a walk and scored a run. Starter Ranger Suarez was roughed up for eight hits and six runs in just four innings of work. He walked one and struck out two.

The Phillies still have an outside shot of claiming the top spot in the National League playoffs. They’ll need to make up three games on the front-running Milwaukee Brewers with just six games left in the regular season. Cristopher Sanchez takes the ball in game one of the series, trying to improve upon what has been a career year for the lefty. Sanchez has a career-high 13 wins this season in 30 starts. Sanchez also has a career-high 21 quality starts. He has allowed 166 hits in 189.1 innings pitched. Sanchez has walked 43 batters and struck out a career-high 198 strikeouts. The Phillies have won four of Sanchez’s last five starts. He is an impressive 6-0 at home with a 2.22 ERA in 13 starts.

Key Injuries: SS Trea Turner, RP Jordan Romano, RP Jose Alvarado, and CF Justin Crawford are out.

Marlins vs. Phillies 

Money line Pick for Marlins vs. Phillies 

  • Phillies ML (4 units)

The Phillies are likely locked into the #2 seed in the NL playoffs, but still have an outside shot at claiming the top spot in the NL East. Still, starter Sanchez should be motivated on Tuesday night to continue what has been a career year for the southpaw. Sanchez is a perfect 6-0 at home this season with an ERA close to 2.50. He is also just two strikeouts shy of 200 for the season. With potentially one more start on Sunday, Sanchez also has a chance to surpass 200 innings for the season. Marlins’ starter Cabrera is just returning from the IL and is likely to be on a pitch count. The Phillies are also an impressive 64-39 at night this season. Sanchez will stay undefeated at home this season, and you can expect a Phillies’ victory.

Take the Phillies with the money line.

Over/Under Pick for Marlins at Phillies

  • Over (4 units)

The Phillies have gone over the number in four of Sanchez’s last five starts. They are hitting .260 as a team overall, and even better at home. Overall, the team has gone over the number in three of its last five games. The Marlins have gone over the number in three of Cabrera’s last five starts. The Marlins have also gone over the number in three of their last five games. Ride these trends on Sunday.

Take the Over.

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