Miami Marlins vs San Francisco Giants Picks and Prediction for Saturday April 25 2026

By: Eddie Kline Published 04/25/2026, 05:15 AM ET
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In Saturday afternoon MLB action, the Miami Marlins and the San Francisco Giants will continue their weekend series from Oracle Park. The Marlins have dropped six of their previous ten games. Miami has been competitive with an overall record of 12 wins and 13 losses. The Giants are off to an underwhelming start and have split their previous ten games. San Francisco currently owns a record of 11 wins and 14 losses. Read more about this Tampa Bay vs Pittsburgh prediction! Struggling with handicapping? Try our free MLB picks.

  • Game day: Saturday, April 25, 2026
  • Game time: 4:05 PM ET
  • Location: San Francisco, CA
  • Stadium: Oracle Park
  • TV channel: MLB.tv

Miami still a few years away from contending

The Miami Marlins have made just four playoff appearances in their franchise history, but have won two World Series titles. The Marlins have dropped seven of their first nine road games and are 5.5 games out of first place in the NL East Division standings. Miami ranks ninth in the majors with a .721 OPS and averages 4.48 runs per contest.

Twenty-six year old SS Xavier Edwards is off to a hot start at the plate. Edwards leads Miami with 31 hits and an impressive .411 on base percentage. C Liam Hicks has provided plenty of power for the Marlins with four home runs and a team-high 21 RBIs. 2B Otto Lopez is hitting .315 with three home runs and 11 RBIs.

San Francisco struggling to stay relevant

The San Francisco Giants have won just one NL West Division title since 2013 and hired college head coach Tony Vitello to turn things around. The Giants are three games below .500 at home and are sitting in fourth place in the division standings. San Francisco is off to a slow start at the plate and ranks near the bottom of the majors with a .637 OPS.

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2B Luis Arraez signed a one-year, 12-million dollar free agent contract and leads San Francisco with a .319 batting average. SS Willy Adames has racked up 21 hits, ten have gone for doubles and three have cleared the wall. Steady 3B Matt Chapman is hitting .291 and has plated a team-best 11 runs for the Giants.

Pitching Matchup

Miami

Twenty-three year old righty Eury Perez (2-1 4.15 ERA) will take the mound for the Marlins in this matchup. Through 26 innings of work, Perez has struck out 27 batters and owns a respectable 1.35 WHIP. Last time out, Perez allowed one unearned run across six frames to lead Miami to a 5-3 home victory versus Milwaukee.

Miami ranked near the bottom of the majors in pitching last season, but is currently 12th with a 3.93 ERA. The Marlins have been particularly strong in relief with a 3.64 ERA. New closer Pete Fairbanks has notched a team-high five saves and owns an impressive 1.04 WHIP.

San Francisco

The Giants will counter with 2021 American League Cy Young Award winner Robbie Ray (2-3 2.86 ERA) on Saturday. Through five starts, Ray (28.1 IP) has fanned 31 batters and sports a sparkling 1.09 WHIP. In his last start, Ray (6 IP) gave up seven hits and three runs during a 3-0 road loss against Washington.

For San Francisco to remain competitive in the NL West Division, the pitching staff will have to be above average. The Giants currently rank 11th in the majors with a 3.77 ERA and have logged ten quality starts. San Francisco uses a closer by committee approach and the bullpen is 5th in the majors with a 3.24 ERA.

Miami Marlins vs San Francisco Giants Spread Pick

  • Miami Marlins

Miami has not fared well on the road, but San Francisco is hard to back as a home favorite. The Giants are just 2-4 as favorites overall and as a result are -$131 at home for bettors to start the year. Perez is coming off a sharp start for the Marlins and the bullpen will shut the door. Take Miami to win on the road.

Miami Marlins vs San Francisco Over/Under Pick

  • UnderΒ 

Miami has done well for over bettors to start the season with a 14-9-2 O/U record, while San Francisco has been playing lower scoring games with a 10-12-3 O/U mark. With two starting pitchers capable of shutting down the opposing lineups and two solid bullpens waiting, this game will stay under.

Final Score Prediction, Miami Marlins win 4-2.

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