Milwaukee Brewers vs. Minnesota Twins Picks and Prediction for Saturday, May 16th, 2026

By: Adam Rauzino Published 05/16/2026, 04:15 AM ET
Milwaukee Brewers vs. Minnesota Twins prediction.
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The Milwaukee Brewers (24-17, 26-15 ATS, 20-20-1 O/U) and the Minnesota Twins (20-24, 21-23 ATS, 28-15-1 O/U) resume a three-game series on Saturday evening, and we have you covered with the prediction. The Brewers are going with Logan Henderson on the mound. The Twins will answer with Connor Prielipp. Milwaukee went 4-2 against Minnesota last season.

Can Henderson post his first win of the season? Keep reading to see the Brewers vs. Twins prediction.Β  Do you need a boost in your handicapping? Try ourΒ  MLB Picks!

Brewers Seek First Win of Season

Logan Henderson will be on the rubber in this one. Henderson was solid in his recent effort, conceding just two runs and walked one in five innings against the Yankees, leading to a no-decision in a game the Brewers won. The rookie righty has kept his opponent to two or fewer runs in all three outings, leading to a 4.15 ERA, a 0.92 WHIP, and an 0-1 record in 13.1 innings of work. He has racked up 16 strikeouts.

The Milwaukee Brewers are at the beginning of a road trip. The squad is having another promising season. They issued a home sweep against a hot Yankees team last weekend. They had more success after winning two of three home meetings against a good Padres squad this week, led by the pitching, keeping a potent offense to eight runs. The Brewers are 9-8 on the road,

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Jake Bauer has been a threat, amassing a strong .943 OPS in May. The 30-year-old first baseman has piled up 21 RBIs and anΒ  .818 OPS. Brice Turang has been the Brewers' most consistent hitter. The 26-year-old second baseman has registered a .950 OPS in May and has amassed 27 RBIs and a .933 OPS on the season.

William Contreras has added six RBIs this month. The veteran catcher is having another outstanding season, producing 26 RBIs and a .754 OPS. He posted two RBIs against Minnesota last season. Jackson Chourio made his season debut last week after missing the first month of the season. The 22-year-old outfielder has issued a .715 OPS. Luis Rengifo is slumping in his first season with the Brewers, knocking in 14 runs with an abysmal .578 OPS. Christian Yellich is back in action off the IL. The Brewers have a solid pen with a 3.45 ERA.

Milwaukee is scoring an average of 5.10 runs per game, ranking them third. The pitching staff is solid, recording a 3.35 ERA, placing them third in the big leagues.

Prielipp Eyes Second Win of Season

Connor Prielipp will be on the rubber on Saturday. Prielipp conceded four runs (one earned) in five innings against Cleveland in his recent start and was labeled with the loss. The rookie southpaw has been tremendous in his first taste of the big leagues, conceding two or fewer runs in each outing and is sporting a 3.32 ERA, a 1.00 WHIP, and a 1-1 record in 19 innings of work. Prielipp has yet to pitch against the Brewers in his career.

The Minnesota Twins are attempting to inch closer to the .500 mark. They are not a contender but find themselves only three games out of first in a weak division. Minnesota secured a series win against Cleveland last weekend. Next, the Twins were able to take two of three home encounters against Miami, scoring 17 runs and keeping them to 10 runs. The Twins stand at 12-11 at home.

Ryan Jeffers has consistently produced all season. The veteran catcher has yielded a .978 OPS this month and has earned 25 RBIs and a stellar .940 OPS on the season. Byron Buxton is in a groove, bashing seven bombs with 12 RBIs this month. The star centerfielder has netted 23 RBIs and an .899 OPS on the year.

Luke Keaschall has produced a robust .768 OPS in May. The 23-year-old second baseman has posted 15 RBIs on the season. Trevor Larchach had the best season of his career in 2025 and has been decent this season, amassing 11 RBIs and a .780 OPS. Austin Martin could be having a breakout season. The outfielder is hitting .333 with a strong .882 OPS.

Minnesota is posting an average of 4.80 runs per game, ranking them eighth. The pitching has been a weakness, amassing a 4.50 ERA, pegging them 25th in the big leagues.

Milwaukee vs. Minnesota Pick

Spread Pick for Milwaukee vs. Minnesota

  • Milwaukee Brewers -120 (5 units)

The Milwaukee Brewers are in a groove. They have won five of their past six games, including a sweep against the Yankees in that span and a series win against the Padres. The Minnesota Twins have not been an ideal team to back at home. They have dropped two of their past three home series.

Furthermore, Brewers pitcher Logan Henderson has been steady, conceding two or fewer runs in all three of his outings this season. Twins pitcher Connor Prielipp has been decent but is not pitching deep into games. He has pitched five or fewer innings in all four of his outings. This is not ideal considering the Twins' weak bullpen. The Twins have lost in three of Prielipp's four starts this season.

Over/Under Pick for Milwaukee vs. Minnesota

  • Over 8.5 (5 units)

I expect this one to have scoring. Milwaukee ranks in the top 10 in all offensive categories, and the Twins' pitching is a major weakness. They have an abysmal bullpen that stands near the bottom with a weak 5.38 ERA.

In addition, Minnesota is producing offense. They have scored at least four runs in five of their past seven games. While Henderson has been solid, he is a rookie with just 13 innings pitched this season. The over is a convincing 7-3 in the Twins' past 10 games.

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