Milwaukee Brewers vs. Pittsburgh Pirates Picks and Prediction for Friday, September 5, 2025
A pair of National League teams on opposite sides of the playoff cut line kick off a weekend series on the diamond in search of a win in the Steel City as the Milwaukee Brewers are on the road as they open a three-game series with the Pittsburgh Pirates Friday evening and we have you covered with our Brewers vs. Pirates prediction. Milwaukee was blanked 2-0 in the rubber game of a three-game set against the Phillies at home on Thursday. Pittsburgh finished a three-game sweep at home against the Dodgers, prevailing 5-3 Thursday in the finale. In the season series between the teams, the Brewers own a 7-3 advantage, including a three-game sweep at home August 11-13 in the most recent series. Read more about this Brewers vs. Pirates prediction! Winning isn’t easy so you need the top MLB cappers.
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Brewers Looking to Maintain NL Central Advantage
Milwaukee lost two of three at home to Philadelphia in a battle of division leaders as they fell in the rubber game Thursday. The Brewers entered Friday 86-55 and held a 5.5-game lead over the Cubs in the NL Central. Against Philadelphia in the series finale Thursday, Milwaukee finished with seven hits as Andrew Vaughn had three and Caleb Durbin added a pair. The Brewers went zero for 10 with runners in scoring position and left eight runners on base in the loss. Freddy Peralta threw five scoreless innings, allowing two hits with three walks and eight strikeouts, but didn’t factor in the decision. Tobias Myers (1-2) took the loss as he allowed one run on two hits with no walks and one strikeout in two-thirds of an inning of relief.
Quinn Priester is on the mound for Milwaukee as he makes his 26th appearance, 21st start, of the year in the series opener. He is 11-2 with a 3.28 ERA, a 1.243 WHIP, 45 walks and 107 strikeouts over 134.1 innings of work this season. Priester didn’t factor in the decision in his last start, which came against the Blue Jays on the road Saturday night. He threw six innings, allowing one run (none earned) on five hits with no walks and three strikeouts in a 4-1 Brewers victory. In his last three starts, Priester is 0-0 with a 1.72 ERA, a 1.28 WHIP, six walks and 12 strikeouts over 15.2 innings of work. Priester didn’t factor in the decision in his lone career start against the Pirates, which came on the road May 24. He threw six innings, allowing one run on six hits with one walk and seven strikeouts in a 2-1 Brewers defeat. Priester is 2-4 with a 7.26 ERA, a 1.765 WHIP, 15 walks and 31 strikeouts over 39.2 innings of work in nine career appearances, seven starts, at PNC Park.
Pittsburgh Trying to Play Spoiler Again
Pittsburgh capped a sweep of the Dodgers by prevailing Thursday in the series finale to ring up their 11th time in 14 games. The Pirates entered Thursday night 64-77 and in the basement of the NL Central, 22 games behind the Brewers for the top spot. They were 11.5 games behind the Mets for the final wild card spot in the National League playoff picture. Against Los Angeles on Thursday, Pittsburgh finished with nine hits as Jared Triolo (run) and Bryan Reynolds (two runs, RBI) each had a pair in the game. Paul Skenes (10-9) earned the win as he threw six innings, allowing no runs on two hits with one walk and eight strikeouts. Colin Holderman got the final two outs, allowing no runs on one hit with no walks and one strikeout, for his first save.
Johan Oviedo is on the mound for the Pirates as he makes his fifth start of the season in this contest. He is 2-0 with a 2.60 ERA, a 1.20 WHIP, eight walks and 20 strikeouts over 15 innings of work. Oviedo earned the win in his last start, which came against the Red Sox on the road Saturday. He threw five innings, allowing two runs on three hits with three walks and six strikeouts in a 10-3 Pirates triumph. In his last three starts, Oviedo is 2-0 with a 2.57 ERA, a 0.93 WHIP, five walks and 17 strikeouts over 14 innings of work. Oviedo makes his seventh career appearance, fourth start, against the Brewers in this contest. He is 2-2 with a 4.50 ERA, a 1.231 WHIP, 10 walks and 20 strikeouts over 26 innings of work against them. Oviedo is 6-7 with a 4.08 ERA, a 1.235 WHIP, 42 walks and 92 strikeouts over 103.2 innings of work in 20 career starts at PNC Park.
Brewers vs. Pirates Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Spread Pick for Brewers vs. Pirates
- Milwaukee Brewers (4 units)
Sure, Pittsburgh has been hot the last couple of weeks but the fact remains that the team is still 13 games below .500 and out of the NL Central chase. The Pirates have sputtered against Milwaukee this season and the Brewers are an explosive offensive team on the road. Oviedo may be 2-0 on the year but he is hardly overpowering at this stage of his career. Priester, despite not factoring in the decision in his last three starts, has been a major key to the Brewers’ success this season. The Brewers are primed to bounce back after falling Thursday. Look for the bats to break out in a big way to deliver a victory.
Over/Under pick for Brewers vs. Pirates
- Over (4 units)
Milwaukee has seen the under post a 64-59-3 mark in their 126 games in relation to the total this season entering Friday. The Brewers are 3rd in the majors in runs per game with 5.09 and that number climbs to 5.59 runs per game on the road. Milwaukee has seen an average total of 9.02 runs per game this season and that number climbs to 9.66 runs per game away from American Family Field on the year. Pittsburgh has seen the under post a 77-56-5 mark on the year heading into Monday night’s action. The Pirates are 30th in the majors with 3.67 runs per game and that number climbs to 3.99 runs per game at PNC Park. Pittsburgh has an average total of 7.72 runs per game but that number slips to 7.60 runs per game at home. With Pittsburgh struggling offensively, the Brewers do the heavy lifting to push this over the number.
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