Milwaukee Brewers vs. San Diego Padres Picks and Prediction for Tuesday, September 23, 2025
Use Code WWWC It’s the continuation of a three-game series between National League rivals on the diamond in southern California as the Milwaukee Brewers travel to face the San Diego Padres in the middle game of a three-game set Tuesday night and we have you covered with our Brewers vs. Padres prediction. Milwaukee dropped the rubber game of their weekend series against the Cardinals as they fell 5-1 Sunday afternoon. San Diego took the rubber game of an interleague set on the road from the White Sox, prevailing 3-2 Sunday afternoon. This article was published before the conclusion of the opening game of the series at Petco Park on Monday night. Read more about this Brewers vs. Padres prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Brewers Trying to Lock Down Home Field Advantage
Milwaukee lost for just the second time in six games as they were beaten in the rubber game of their set with the Cardinals on the road Sunday. The Brewers entered Monday 95-61 and have clinched the NL Central crown. They held a three-game lead over Philadelphia in the race for home-field advantage in the NL playoffs. Against St. Louis in the series finale Sunday, Milwaukee finished with seven hits as Andruw Monasterio led the way with three while Bryce Perkins and Joey Ortiz (run) each recorded a pair. The Brewers went zero for seven with runners in scoring position and left 10 men on base in the game. Robert Gasser (0-1) took the loss as he allowed two runs on one hit with two walks and two strikeouts over three innings of work.
The Brewers have not announced an official starter for this contest, but the expectation is that the recently called-up Bruce Zimmermann gets the ball for his first start of the year. He spent the entire season with Triple-A Nashville of the International League, where he made 28 appearances, 21 starts, this season. Zimmermann was 10-7 with two saves, a 4.11 ERA, a 1.232 WHIP, 30 walks and 109 strikeouts over 138 innings of work this season. In his 39th career appearance, 28th major league start, Zimmermann pitches against the Padres for the first time here. As a result, this marks his first career outing at Petco Park as well.
San Diego Looking to Secure Playoff Position
San Diego won their second straight as they won the rubber game of their three-game interleague set with the White Sox on Sunday. The Padres entered Saturday 85-71 on the season and stood second in the NL West, three games behind the Dodgers for the top spot. They held the second wild card spot in the NL playoff picture, five games ahead of the Mets and Reds. Against the White Sox on Sunday, San Diego finished with 10 hits as Ryan O’Hearn recorded three to lead the way. Fernando Tatis Jr. (his 23rd) homered in the contest for the Padres. Michael King (5-3) threw five scoreless innings, allowing four hits with four walks and four strikeouts, to earn the win. Robert Suarez worked a 1-2-3 ninth, striking out two, for his 40th save of the season.
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Randy Vasquez is on the mound for the Padres in the opening game of this set as he makes his 27th appearance, 26th start, of the season. He is 5-7 with a 3.94 ERA, a 1.361 WHIP, 50 walks and 74 strikeouts over 125.2 innings of work on the year. Vasquez took the loss in his last start, which came Thursday on the road against the Mets. He threw 2.1 innings, allowing four runs on four hits with one walk and three strikeouts in a game the Padres lost 6-1. In his last three starts, Vasquez is 2-1 with a 3.77 ERA, a 1.19 WHIP, one walk and 15 strikeouts over 14.1 innings of work. Vasquez makes his third career start against the Brewers in this contest. He is 1-0 with a 0.00 ERA, a 1.448 WHIP, seven walks and five strikeouts over 9.2 innings of work against them. Vasquez is 3-5 with a 3.34 ERA, a 1.305 WHIP, 34 walks and 68 strikeouts over 105 innings of work in 20 career starts at Petco Park.
Brewers vs. Padres Pick
Moneyline Pick for Brewers vs. Padres
- Padres (4 units)
Milwaukee is the top team in the majors, but its rotation is in flux at the moment as both Jose Quintana and Brandon Woodruff are on the IL right now. The Brewers have not named a starter here, so this could turn into a glorified bullpen game. San Diego is still trying to catch the Cubs for home-field advantage in the wild-card round and still has a shot at catching the Dodgers for the top spot in the NL West. The Padres are a stellar 47-28 at Petco Park entering Monday, and with the Brewers dealing with some pitching woes, take San Diego here to keep the pressure on both the Dodgers and the Cubs.
Over/Under Pick for Brewers vs. Padres
- Over (4 units)
Milwaukee has seen the under post a 76-75-5 mark in their 156 games in relation to the total this season entering Monday. The Brewers are 3rd in the majors in runs per game with 5.06 and that number climbs to 5.35 runs per game on the road. Milwaukee has seen an average total of 8.97 runs per game this season and that number climbs to 9.40 runs per game away from American Family Field on the year. San Diego entered Monday night 19th in the majors with 4.26 runs per game, while they allow an average of 3.85 runs per contest. That gives the Padres an average total of 8.14 runs a contest. They average 4.36 runs per game at home while allowing an average of 3.45 runs per game, giving them an average total of 7.81 runs per game at Petco Park. San Diego has seen the under post an 84-66-6 mark in their 156 games on the year. Still, with Vasquez having his issues, the Brewers’ offensive firepower and their questionable pitching situation, take this one to wind up over the number.
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