Milwaukee Brewers vs. San Diego Padres Picks and Prediction for Wednesday, September 24, 2025
Use Code WWWC It’s the conclusion of a three-game series between National League rivals on the diamond in southern California as the Milwaukee Brewers travel to face the San Diego Padres in the final game of a three-game set Wednesday afternoon and we have you covered with our Brewers vs. Padres prediction. In the opening game of the series Monday night, it was the Padres picking up a 5-4 win in 11 innings to draw first blood. Will Milwaukee leave town with momentum or can San Diego take the series by prevailing here? This article was published prior to the conclusion of the middle game of the series at Petco Park Tuesday night. Read more about this Brewers vs. Padres prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Brewers Hoping to Secure Top Seed in NL Playoff Picture
Milwaukee fell for the third time in four games as they were downed in the opening game of this series Monday night. The Brewers entered Tuesday 95-62 and have clinched the NL Central crown. They held a 2.5-game lead over Philadelphia in the race for home-field advantage in the NL playoffs. Against San Diego in the series opener Monday, Milwaukee finished with seven hits as Andrew Vaughn (run) and Chad Durbin (RBI) each had two. The Brewers were three of 11 with runners in scoring position and left 12 men on base in the game. Freddy Peralta threw five innings, allowing two runs on four hits with one walk and six strikeouts, but didn’t factor in the decision. Grant Anderson (2-6) took the loss in relief as he allowed one run (none earned) on one hit with no walks or strikeouts in one-third of an inning of work.
Quinn Priester is on the mound for Milwaukee as he makes his 29th appearance, 24th start, of the year in the middle game of the set. He is 13-2 with a 3.25 ERA, a 1.214 WHIP, 49 walks and 128 strikeouts over 152.1 innings of work this season. Priester didn’t factor in the decision in his last start, which came against the Angels at home Thursday. He threw 5.2 innings, allowing two runs on three hits with two walks and 10 strikeouts in a 5-2 Brewers victory. In his last three starts, Priester is 2-0 with a 3.00 ERA, a 1.00 WHIP, four walks and 21 strikeouts over 18 innings of work. Priester earned the win in his lone career start against the Padres, which came with the Pirates on the road July 24, 2023. He threw 5.1 innings, allowing four runs on four hits with three walks and four strikeouts in an 8-4 Pirates victory. Since that outing came at Petco Park, Priester is 1-0 with a 6.75 ERA, a 1.313 WHIP, three walks and four strikeouts over 5.1 innings of work.
San Diego Keeping Pressure In NL West
San Diego earned a third straight win as they won Monday night’s opener in walk-off fashion at home. The Padres entered Tuesday 86-71 on the season and stood second in the NL West, 2.5 games behind the Dodgers for the top spot. They have clinched at least a wild card spot and trail the Cubs by 2.5 games for the top wild card spot. Against the Brewers on Monday, San Diego finished with nine hits as Jackson Merrill and Jose Iglesias (two runs, RBI) each had a pair. Iglesias (his second) went deep for the Padres in the contest as the team was two of nine with runners in scoring position and left 11 men on base. Nick Pivetta threw 5.2 innings, allowing three runs on four hits with five walks and five strikeouts, but didn’t factor in the decision. Bradgley Rodriguez (1-0) earned the win with a scoreless 11th inning, allowing one hit with one walk and no strikeouts, in relief.
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Dylan Cease is on the mound for the Padres as he makes his 32nd start of the season in this contest. He is 8-12 with a 4.64 ERA, a 1.319 WHIP, 69 walks and 207 strikeouts over 163 innings of work on the year. Cease took the loss in his last start, which came against the White Sox on the road Friday night. He threw six innings, allowing four runs on four hits with three walks and six strikeouts in a 4-3 Padres loss. In his last three starts, Cease is 2-1 with a 3.18 ERA, a 1.12 WHIP, six walks and 17 strikeouts over 17 innings of work. Cease makes his fourth career start against the Brewers in this contest. He has a 1-1 record with a 3.57 ERA, a 1.245 WHIP, nine walks and 24 strikeouts over 17.2 innings of work against them. Cease is 13-11 with a 3.48 ERA, a 1.154 WHIP, 61 walks and 218 strikeouts over 173.1 innings in 30 career starts at Petco Park.
Brewers vs. Padres Pick
Moneyline Pick for Brewers vs. Padres
- Brewers (4 units)
San Diego took the opening game of this set to keep pressure on both the Dodgers and Cubs for the NL West race and the race for the top wild-card spot. Cease has had a tough season as he has a losing record despite racking up an impressive 11.4 strikeouts per nine innings, which leads the National League. Milwaukee has clinched the NL Central and they are dealing with some injuries to their rotation. With that said, the Brewers have won a staggering 19 consecutive outings when Priester has pitched, dating back to May 30. Milwaukee may play it safe and limit Priester’s innings, but the Brewers are the better offensive team, which gives them the win here.
Over/Under Pick for Brewers vs. Padres
- Under (4 units)
Milwaukee has seen the under post a 76-76-5 mark in their 157 games in relation to the total this season entering Tuesday. The Brewers are 3rd in the majors in runs per game with 5.06 and that number climbs to 5.33 runs per game on the road. Milwaukee has seen an average total of 8.97 runs per game this season and that number climbs to 9.39 runs per game away from American Family Field on the year. San Diego entered Tuesday night 19th in the majors with 4.27 runs per game while they allow an average of 3.88 runs per contest. That gives the Padres an average total of 8.15 runs a contest. They average 4.37 runs per game at home while allowing an average of 3.46 runs per game, giving them an average total of 7.83 runs per game at Petco Park. San Diego has seen the under post an 84-67-6 mark in their 157 games on the year. Both pitchers have been decent at run prevention and we needed extra innings to get over the mark Monday. Take the under in this contest as a result.
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