Milwaukee Brewers vs. San Diego Padres Picks and Prediction, Monday, September 22, 2025
Use Code WWWC On Monday, the Milwaukee Brewers will play the San Diego Padres at Petco Park, and we have you ready to go with our Brewers vs. Padres prediction. First pitch is at 6:40 p.m. ET.
This is the second series of the season between Milwaukee and San Diego. The Padres won two of three in that series and are 7-3 in the last ten matchups between these ballclubs. The over was 6-4 in those ten games. If you want the Brewers vs. Padres prediction, read on and check out our MLB Predictions to beat the sportsbooks!
Can Milwaukee keep its momentum on the road?
Milwaukee (95-61 SU, 85-71 RL, and 75-76-5 O/U) lost two of three to St. Louis in its previous series. The Brew Crew is 6-4 in the last ten games (the over was 6-4).
Milwaukee is starting right-hander Freddy Peralta on Monday against San Diego. In his last outing, the 29-year-old allowed one run and two hits in six innings against the Angels. He is 17-6 with a 2.65 ERA and 1.07 WHIP in 31 starts (169.2 IP) this season, including 8-5 with a 3.71 ERA and 1.16 WHIP in 15 road starts (80.0 IP).
Get Free $30 Credit for Premium Picks + Exclusive Discounts
Subscribe Now
The Brewers have been postseason contenders for the past few seasons but have struggled when the lights were bright, posting a 2-10 record in the playoffs since 2019. Milwaukee turned a corner in June (16-9) and has dominated since then. Will they sustain their pace in the postseason?
Milwaukee Brewers Baseball Injury Report: No injuries for Monday's game versus the Padres.
Padres' magic number is one
San Diego (85-71 SU, 85-71 RL, and 66-84-6 O/U) won two of three against Chicago (AL) in its previous series. The Padres are 6-4 in their last ten games (the over/under was split 5-5).
SD will hand the baseball to right-hander Nick Pivetta on Monday against Milwaukee. In his last outing (4.2 IP no-decision vs the Mets), the 32-year-old surrendered three runs on seven hits, giving up three homers. He is 13-5 with a 2.81 ERA and 0.97 WHIP in 30 starts (176.0 IP), including 8-1 with a 2.22 ERA and 0.82 WHIP in 16 home starts (97.1 IP).
San Diego was off to a hot start to the second half of this season, briefly overaking the Dodgers for the lead position in the division race. The Friars are only three games out of first in the NL West, but it may take a series sweep or two to take back the lead from LA. San Diego has played well in front of its home crowd (47-28 record), but is 37-43 on the road. Can the Padres play consistently enough to make a deep run in the 2025 MLB postseason?
San Diego Padres Baseball Injury Report: No new injuries for Monday's game against the Brewers.
Brewers vs. Padres Pick
Moneyline Pick for Brewers vs. Padres
- Milwaukee ML (4 Units)
Peralta has fared well against San Diego, holding the home team to a .125 BA/.266 SLG/.209 wOBA with a 34.3% K% in 70 combined plate appearances. He is holding opponents to a .173 BA in the second half of the season and held the Padres to one hit and zero runs in six innings on June 8. Pivetta hasn't been as successful against Milwaukee, as current Brewers hitters boast a .317 BA/.540 SLG/.388 wOBA in 74 plate appearances against him. He's also coming off a sub-par outing in his last start.
Over/Under Pick for Brewers vs. Padres
- Under 7 (5 Units)
This is a top-tier pitching matchup. Peralta has been steady and consistent all year, and he has solid career stats against San Diego. Pivetta has been very effective at Petco Park and has held 13 of his last 15 opponents to three or fewer runs. These bullpens are also elite, ranking 1st and 10th in ERA this season. Milwaukee and San Diego will play a competitive, low-scoring game on Monday night in America's Finest City.
Never Tried Winners and Whiners? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code DOLLAR
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
- Check out more MLB predictions
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
