Milwaukee Brewers vs. St. Louis Cardinals Picks and Prediction for Friday, September 19th, 2025
Use Code WWWC The Milwaukee Brewers (93-59, 84-68 RL, 74-73-5 O/U) meet the St. Louis Cardinals (74-79, 73-80 RL, 76-69-8 O/U) as the rivals open a three-game series on Friday evening, and we have the prediction. The Brewers are going with Jacob Misiorowski. The Cardinals will reply with Sonny Gray. The Brewers lead the season series 6-4.
Can Jacob Misiorowski record his sixth win of the season for the Brewers on Friday? Check out the Brewers vs. Cardinals prediction. Nobody does it better when it comes to MLB Picks!
Misiorowski Seeks Sixth Win of Season
Jacob Misiorowski is on the mound on Friday evening. Misiorowski was shaky in his recent outing against this Cards team, squandering four runs in five innings, resulting in a no-decision in a game the Brewers won. The rookie had a historic start to his career when he was promoted in June, but has been mediocre the past few months. Misiorowski has recorded a 4.35 ERA and a 1.13 WHIP, accompanied by a 5-2 record in 60 innings of work. He has kept St. Louis to four runs in 10 innings this season.
The Milwaukee Brewers are beginning a road trek in this one. The squad should secure the division soon, considering they are five games ahead of the Cubs. The Brewers are seeking the best record in the big leagues. They have 93 wins while the Phillies have 91 wins. The Brewers won the first two games of their home series against the Angels this week, entering Thursday evening, aided by pitching, keeping them to just four runs. The squad is 43-32 on the road.
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Christian Yelich has amassed a .705 OPS this month. The star outfielder is having a superb season, bashing 29 homers with 99 RBIs. Andrew Vaughn continues to thrive at the plate, posting a 1.03 OPS in September. The 27-year-old first baseman has 61 RBIs and a .711 OPS on the year. William Contreras has posted seven RBIs this month. The veteran catcher is having a productive season, clubbing 17 home runs with 76 RBIs and a .768 OPS. Jackson Chourio has exposed the Cardinals, posting nine RBIs and a 1.09 OPS. The 21-year-old has 20 home runs with 76 RBIs on the season.
Milwaukee is averaging 5.11 runs on the year, good for second. The pitching is a strength, posting a strong 3.61 ERA, good for second.
Cardinals Near End of Disappointing Season
The Cards are opting with Sonny Gray on the mound. Gray was strong in his previous effort, conceding two runs in five innings against Milwaukee, ending in a no-decision in a clash the Cardinals lost in extras. The veteran squandered three or more runs in three of his past five outings and has issued a 4.43 ERA and a 1.22 WHIP, accompanied by a 13-8 record in 168.2 innings pitched on the year. He has poor numbers against Milwaukee, reporting a 4.63 ERA and a 4-6 record in 19 meetings.
The St. Louis Cardinals are nearing the end of a disappointing season. They never held a playoff spot at any point. The Cards are hoping to at least finish with a .500 record. The Cardinals lost a series against Milwaukee last weekend and dropped two of three home encounters against the Reds before this series. The pitching staff squandered 17 runs. The Cards are 42-36 at home.
Brendan Donovan recently returned from injury. The veteran second baseman has managed 47 RBIs and a strong .755 OPS. Willson Contreras has managed five RBIs this month. The veteran first baseman is having a strong year, bashing 20 homers with 79 RBIs and a .790 OPS. He is on the IL and is done for the season. Nolan Arenado is back in action after missing 1.5 months. The veteran third baseman has two RBIs against the Brewers this season. Arenado has issued 45 RBIs and a .654 OPS. Ivan Herrera has nine RBIs this month. The young catcher is having an outstanding season, posting 15 home runs along with 58 RBIs.
St. Louis is posting an average of 4.27 runs on the year, marking them 20th. The pitching staff has a 4.29 ERA, positioning them 21st.
Milwaukee Brewers vs. St. Louis Cardinals Pick
Spread Pick for Brewers vs. Cardinals
- Milwaukee Brewers -120 (5 units)
The Milwaukee Brewers continue to succeed, winning four of their past five games entering Thursday evening. These are big games considering they have yet to secure the division ahead of the Cubs, plus it's important to finish with the best record for playoff seeding. The Brewers have two more wins than the Phillies. The St. Louis Cardinals are just playing out the rest of the season. They have dropped five of their past six games.
Furthermore, Brewers pitcher Jacob Misiorowski has kept the Cardinals to only four runs in 10 innings this season. The Brewers have won in four of their past six starts. Cardinals pitcher Sonny Gray has struggled against Milwaukee this season, squandering 11 runs in 15.1 innings of work. He has been shaky recently, surrendering 12 runs in his past 16.1 innings pitched. The Brewers have won six of the 10 meetings this season.
Over/Under Pick for Brewers vs. Cardinals
- Over 7.5 (5 units)
I expect crooked numbers on the board. Milwaukee has done big damage against the Cardinals this season, averaging five runs per game in the 10 meetings. Milwaukee continues to rake, scoring 36 runs in its past five games entering Thursday evening.
In addition, Jacob Misiorowski is nearly as strong on the road, where he has reported a 5.61 ERA on the season. The rookie has not been quite as dominant as early in the season, conceding three or more runs in five of his past six outings. The over is a convincing 5-1 in the Brewers' past six games.
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