Milwaukee Brewers vs. St. Louis Cardinals Picks and Prediction for Sunday, September 21, 2025
Use Code WWWC It’s the final game of a three-game series between NL Central rivals on the diamond in the Gateway City as the Milwaukee Brewers travel to face the St. Louis Cardinals Sunday afternoon and we have you covered with our Brewers vs. Cardinals prediction. In the opening game of the series Friday night, the Cardinals picked up a 7-1 victory to give them a shot at a series win regardless of Saturday’s result. Which team picks up the win on getaway day here? This article was published prior to the conclusion of the middle game of the series at Busch Stadium Saturday night. Read more about this Brewers vs. Cardinals prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Brewers Trying to Lock Down NL Central Crown
Milwaukee lost for just the second time in seven games as they were drubbed in the opening game of the set Friday night. The Brewers entered Friday 94-60 and held a six-game lead over the Cubs in the NL Central. Against St. Louis in the series opener Friday, Milwaukee finished with 12 hits as Jake Bauers paced the team with three, while Jackson Chourio and Christian Yelich each had two in the game. Sal Frelick hit his 12th homer of the year in the contest. The Brewers were zero of eight with runners in scoring position and left 12 men on base in the game. Jacob Misiorowski (5-2) took the loss as he allowed two runs on five hits with three walks and three strikeouts over 3.2 innings of work.
Freddy Peralta gets the ball for Milwaukee here as he makes his 32nd start of the season in this contest. He is 17-6 with a 2.65 ERA, a 1.073 WHIP, 65 walks and 195 strikeouts over 169.2 innings of work this season. Peralta earned the win in his last start, which came Tuesday at home against the Angels. He threw six innings, allowing one run on two hits with two walks and 10 strikeouts, in a 9-2 Brewers triumph. In his last three starts, Peralta is 1-1 with a 3.38 ERA, a 1.06 WHIP, seven walks and 27 strikeouts over 16 innings of work. Peralta makes his 21st career appearance, 17th start, against the Cardinals in this contest. He is 5-6 with a 4.67 ERA, a 1.327 WHIP, 32 walks and 91 strikeouts over 86.2 innings of work against them. Peralta has a 0-3 record with a 4.25 ERA, a 1.25 WHIP, 13 walks and 32 strikeouts over 36 innings in eight career appearances, six starts, at Busch Stadium.
St. Louis Shooting to Play Spoiler
St. Louis won for just the third time in 10 games as they managed to prevail in the opening game of this set Friday night. The Cardinals entered Saturday 75-79 and stood fourth in the NL Central, 19 games behind the Brewers for the top spot. They were five games behind the Mets for the final wild card spot in the National League. Against the Brewers on Friday, St. Louis finished with 14 hits as Alec Burleson (run) led the way with three. The Cardinals went six of 18 with runners in scoring position in the game and left nine men on base. Sonny Gray (14-8) earned the win as he threw six innings, allowing one run on nine hits with no walks and seven strikeouts, before departing.
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Matthew Liberatore gets the ball for the Cardinals in this contest as he makes his 29th start of the season. He is 7-12 with a 4.30 ERA, a 1.309 WHIP, 39 walks and 116 strikeouts over 146.2 innings of work this season. Liberatore didn’t factor in the decision in his last start, which came against the Reds at home Monday night. He threw six innings, allowing three runs (two earned) on four hits with one walk and six strikeouts in an 11-6 Cardinals loss. In his last three starts, Liberatore is 1-1 with a 4.11 ERA, a 1.24 WHIP, five walks and 14 strikeouts over 15.1 innings of work. Liberatore makes his 11th career appearance, fourth start, against the Brewers in this contest. He has a 3-0 record with a 1.14 ERA, a 1.183 WHIP, 12 walks and 25 strikeouts over 23.2 innings of work. Liberatore has a 9-9 record with a 4.00 ERA, a 1.261 WHIP, 40 walks and 131 strikeouts over 153 innings in 54 career appearances, 23 starts, at Busch Stadium.
Brewers vs. Cardinals Pick
Moneyline Pick for Brewers vs. Cardinals
- Brewers (4 units)
While St. Louis took the opening game of this set Friday night, it’s not all that often that the Brewers are going to go zero for eight with runners in scoring position or leave 12 runners on base. Peralta has been solid all season and Milwaukee is trying to lock down the top seed in the NL playoff picture. Liberatore has pitched well against Milwaukee in his career but the fact remains that the Cardinals are in a spoiler role at best at this stage of the season. The Brewers are an explosive team, especially on the road, and they should find a way to prevail here to take another step toward their goal.
Over/Under Pick for Brewers vs. Cardinals
- Under (4 units)
Milwaukee has seen the over post a 75-74-5 mark in their 154 games in relation to the total this season entering Saturday. The Brewers are tied for 2nd in the majors in runs per game with 5.10, and that number climbs to 5.43 runs per game on the road. Milwaukee has seen an average total of 9.01 runs per game this season, and that number climbs to 9.50 runs per game away from American Family Field on the year. St. Louis entered Saturday having seen the over post a 77-69-8 mark on the season. The Cardinals are 18th in the majors by averaging 4.29 runs per game on the season, a number that stays flat at 4.29 runs per game at home. St. Louis gives up 4.62 runs per game overall, a number that drops to 4.28 runs per game at home on the year. That gives the Cardinals an average total of 8.91 runs per game, which tumbles to 8.57 runs per game as the home team. We saw eight runs in the opener, and with Peralta on the bump here, this game likely falls short as well.
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