Minnesota Twins vs Arizona Diamondbacks Picks and Prediction for Sunday, June 21, 2026

By: David Anicetti Published 06/21/2026, 05:30 AM ET
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The Minnesota Twins visit the Arizona Diamondbacks at Chase Field on Sunday at 3:15 PM ET on Peacock. Minnesota enters at 36-41 and sits third in the AL Central, while Arizona is 39-36 and holds second place in the NL West. The Diamondbacks have won four of their last five games and opened this series with a 9-5 victory on Friday night. Minnesota had won four of its previous five contests before that defeat and continues trying to climb back toward the .500 mark. Arizona has been one of the stronger home teams in the National League and enters this matchup with momentum on its side. Cash in a winner with our free MLB picks.

Minnesota Twins Looking to Regain Momentum

Minnesota suffered a disappointing setback in Friday's opener as the pitching staff allowed nine runs and could not contain Arizona's offense. Despite that result, the Twins had been playing some of their best baseball of the month and remain within striking distance in the AL Central standings. The offense has provided enough production to stay competitive, scoring 368 runs while collecting 629 hits and 96 home runs through 77 games.

Byron Buxton continues to lead the lineup, batting .273 with 23 home runs and a .588 slugging percentage. Josh Bell has added 47 RBI, while Brooks Lee has contributed 12 home runs and 42 RBI. Ryan Jeffers has been one of the club's most productive hitters when healthy, posting a .295 average and .949 OPS.

Pitching remains the biggest concern. The Twins carry a 4.78 ERA, 1.39 WHIP, and .254 opponent batting average. While the staff has recorded 625 strikeouts, consistency has been difficult to find. Minnesota will need a much better performance on the mound after Friday's rough outing.

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Injuries: Walker Jenkins (7-Day IL), Mick Abel (15-Day IL), Matt Canterino (60-Day IL), Julian Merryweather (7-Day IL), Kendry Rojas (15-Day IL).

Arizona Diamondbacks Building Momentum at Home

Arizona continues to play quality baseball and has won four of its last five games entering Sunday. The Diamondbacks have scored 29 runs during that stretch and have looked comfortable offensively at Chase Field, where they own a strong 24-15 home record.

Corbin Carroll remains the centerpiece of the lineup, batting .283 with 13 home runs, 42 RBI, and a .925 OPS. Ketel Marte has added 12 home runs and 44 RBI, while Geraldo Perdomo continues getting on base at a high rate with a .356 OBP. Gabriel Moreno has also been productive, batting .275 and providing stability behind the plate.

The Diamondbacks have also received solid work from their pitching staff. Arizona enters with a 4.16 ERA, 1.27 WHIP, and .247 opponent batting average. The rotation has generally kept games under control, and the bullpen has done enough to help the club convert close contests into victories.

Injuries: Carlos Santana (60-Day IL), A.J. Vukovich (60-Day IL), Jordan Lawlar (Day-To-Day), Derek Law (7-Day IL), Michael Soroka (Day-To-Day).

Minnesota Twins vs Arizona Diamondbacks Pick

  • Arizona DiamondbacksΒ 

Arizona has several advantages entering this matchup, including the stronger home record, the better overall pitching staff, and recent momentum. With the Diamondbacks winning four of their last five games and continuing to play well at Chase Field, Arizona is the play on the moneyline, but must play strong in the field to back up whoever is on the mound to start and when the bullpen is called upon..

Minnesota Twins vs Arizona Diamondbacks Over/Under Pick

  • OverΒ 

Friday's opener produced 14 total runs, and another relatively high-scoring game is possible. Minnesota's pitching staff has struggled throughout the season, carrying a 4.78 ERA, while Arizona has scored at least five runs in four of its last five contests. The Twins still possess enough power with Buxton, Bell, and Lee to contribute offensively, making the over the stronger play in this matchup.

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