Minnesota Twins vs Baltimore Orioles Picks and Predictions for Thursday, March 26, 2026

By: Cameron Ross Published 03/26/2026, 05:30 AM ET
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The Minnesota Twins opened the 2026 season Thursday afternoon on the road with a game inside Oriole Park at Camden Yards in Baltimore, MD, against the Baltimore Orioles, and we have you ready to roll with our Minnesota vs Baltimore prediction.  Minnesota comes into the 2026 season with a clean slate, looking to put last year's struggles behind them. The Baltimore Orioles opened the 23 season at home Thursday, looking to improve on last year's failure. The Twins finished last season with 70 wins and 92 losses after losing 18 of 26 games played in September. Baltimore finished last season 12 games below .500, dropping six of the last eight overall, including a three-game sweep on the road in New York to end the season. Read more about this Minnesota vs Baltimore prediction! Struggling with handicapping? Try our MLB Predictions!

Minnesota looks to start in improvement

The Minnesota Twins were a bottom-of-the-barrel offensive team a year ago, ranking 22nd in the MLB with a .238 team batting average. Minnesota concluded the year with 1295 hits for 678 runs. The Minnesota power was solid, however, with 191 total home runs and a .397 team slugging percentage. Minnesota pitching was terrible, ranking 24th in the league with a 4.55 ERA, as the Twins gave up 721 runs on 1,411 hits.

Byron Buxton returns this season from Minnesota as the biggest bat in the lineup from last year after leading the team with a .264 batting average, 35 home runs, and 83 RBI's. Trevor Larnach also returns from Minnesota this season after losing a .250 batting average to go along with seventeen home runs and sixty RBI's in a team high 142 games played last season. Brooks Lee compiled a .236 batting average through 139 games, and catcher Ryan Jeffers added a .266 batting average last season but played just 119 total games.

Key Injury Report for Minnesota:

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  • Julian Merryweather (Day-to-Day)
  • Walke Jenkins (Out)
  • Cory Lewis (Out)
  • Travis Adams (15-Day IL)
  • David Festa (15-Day IL)

Baltimore opens the year with a new look

The Baltimore Orioles offense was horrific a year ago, ranking 24th in the MLB with a .235 batting average. The Orioles scored 677 total runs on 1273 hits. The Orioles' power was stout, however, with 191 total home runs and a .394 team slugging percentage. Baltimore's pitching failed the team last season, ranking 26th in the league with a 4.60 ERA after allowing 733 earned runs on 1,433 hits.

Gunnar Henderson is the top returning bat for Baltimore this season after leading the team with a .274 batting average, seventeen home runs, and 68 RBI's a year ago. Jackson had a .242 batting average last season, and Jordan Westburg added a .265 batting average. The addition of Pete Alonso adds 38 home runs and 126 RBIs from 2025 to the Baltimore lineup.

Key Injury Report for Baltimore:

  • Payton Eeles (Day-to-Day)
  • Heston Kjerstad (10-Day IL)
  • Keagan Gillies (Out)
  • Keegan Akin (15-Day IL)
  • Andrew Kittredge (15-Day IL)

Minnesota vs Baltimore Pick

  • Minnesota vs Baltimore Spread Pick

Baltimore has a new-look roster coming into this matchup and will have a huge edge on Thursday. The Orioles send out an elite pitcher who will have the matchup advantage against Minnesota. Look for Baltimore to back their pitcher in a big way, leading to a lead and the win to start the new season. Take Baltimore to win game one of the season as they start the year undefeated with a home victory against the Minnesota Twins.

  • Minnesota vs Baltimore Over/Under Pick

Both teams had mediocre offenses a year ago, and each will look to improve upon that Thursday. Baltimore is going to have a better unit this year, and it will start in this matchup. Look for Baltimore to do the job on offense and push the total over. Minnesota will go through spurts where they struggle to score on Thursday, but they will also score runs. Take the over on Thursday afternoon as the Minnesota Twins visit the Baltimore Orioles in game one of the season.

 

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