Minnesota Twins vs. Kansas City Royals Picks and Prediction for Saturday, September 6th, 2025
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The Minnesota Twins (62-77, 65-74 RL, 65-65-9 O/U) and the Kansas City Royals (71-69, 69-71 RL, 59-80-1 O/U) resume a three-game divisional series on Saturday afternoon, and we have the details and prediction. The Twins are going with Joe Ryan. The Royals are opting with Stephen Kolek. The season series is 5-5.
Can Ryan continue his dominance of K.C. in this divisional clash on Saturday afternoon? Check out the Twins vs. Royals prediction. Nobody does it better when it comes to MLB Picks!
Joe Ryan Continues Dominance for Minnesota
Joe Ryan is expected to be on the rubber on Saturday. Ryan came through with a gem in his recent effort, posting seven scoreless innings against San Diego, and secured the win. The veteran has been the Twins' ace. He has been inconsistent recently but has outstanding numbers, posting a 3.08 ERA and a 0.97 WHIP, and a 13-7 record in 155 innings of work on the season. He pitched seven scoreless innings against K.C. earlier this season and has a sharp 1.34 ERA and an 8-0 record in 60.1 career innings.
The Minnesota Twins are in the early stages of a road trek. The squad posted a surprising series win against the Padres last week, aided by the bats. Next, they were dealt a disappointing home sweep at the hands of the White Sox this week, dropping all four games due to the pitching. The pitching was exposed, squandering 33 runs. The Twins are 27-42 on the road.
Trevor Larnach has been a tough out. The 28-year-old outfielder has five RBIs in his last six games and 56 RBIs and a solid .745 OPS on the year. Matt Wallner has one RBI in his past five games. The veteran slugger is having a breakout season, clubbing 21 homers with 36 RBIs and a .797 OPS. Austin Martin is getting playing time. The 26-year-old was once a top prospect but has netted two RBIs and a strong .753 OPS in 30 games. Byron Buxton is raking, amassing 10 RBIs in his past seven games. The veteran slugger has bashed 29 home runs with 72 RBIs.
Minnesota is averaging 4.22 runs on the year, ranking them 25th. The pitching staff has been a weakness, recording a poor 4.55 ERA, ranking them 24th. 
Kolek Earns Win in Royals Debut
Stephen Kolek is on the mound. Kolek was acquired in a deal with the Padres in July but was injured and did not make his debut until last week. He was sharp, keeping Detroit to one run in six innings, ending in a no-decision in a game the Royals won. The veteran righty has conceded two or fewer runs in three of his past five outings and is sporting a 3.99 ERA and a 1.26 WHIP, accompanied by a 4-5 record in 85.2 innings on the season. This is his first career meeting against Minnesota.
The Kansas City Royals need wins. They are within reach in the wildcard picture, standing only two games out of a wildcard spot entering Friday evening. The squad dropped a home series against Detroit last weekend and were dealt two defeats against the Angels this week due to a quiet series at the dish. They conceded only 12 runs. The Royals are 37-34 at home.
Vinnie Pasquantino was dominant throughout August and has two RBIs early this month. The 27-year-old first baseman has great numbers, bashing 29 home runs with 96 RBIs. Maikel Garcia has six RBIs in his past 10 games. The 25-year-old second baseman has 15 bombs with 64 RBIs. Michael Massey has not been able to find a groove this season. The veteran second baseman has posted a weak .514 OPS. Bobby Witt Jr. has posted a poor .673 OPS against the Twins this season. The veteran slugger has 21 smashed homers and 76 RBIs on the season.
Kansas City is only averaging 3.85 runs per game, ranking them 29th. The pitching is a strength, posting a 3.6 ERA, good for fourth.
Twins vs. Royals Pick
Spread Pick for Twins vs. Royals
- Minnesota Twins -115 (5 units)
The Minnesota Twins have been competitive against the Royals. They have enjoyed success against their rivals this season, winning two straight series. The Kansas City Royals have been shaky. They are only 5-5 in their past 10 games, including a series defeat at home against the Angels this week, which cost them games in the wildcard.
Furthermore, Twins pitcher Joe Ryan is having an outstanding season. He has dominated the Royals this season, keeping them to just one run in 12 innings pitched. Ryan has issued a stunning 1.34 ERA and an 8-0 record in his career against the rivals. Royals pitcher Stephen Kolek has only made one start in the past month due to injury. He posted a disastrous 5.82 ERA in July and, as mentioned, did not pitch in August and made just the one appearance this month.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vinciletti | +3,530.00 |
| 2 |  Nick Parsons | +951.00 |
| 3 |  Stephen Nover | +743.00 |
| 4 |  Tom Macrina | +196.00 |
| 5 |  Rocky Atkinson | +128.00 |
Over/Under Pick for Twins vs. Royals
- Over 8.5 (5 units)
I expect a barrage of scoring in this game. Minnesota has had no issues generating runs in most games this past month. They have amassed 26 runs in their past five games. They have scored 20 runs in the past five meetings against the Royals.
In addition, Kansas City has averaged a decent 4.1 runs in its past 10 games, above its season average. While Ryan has contained the Royals in his career, the veteran has not been as sharp recently, squandering 11 runs in his past 16 innings pitched. Also, the Twins' bullpen has reported a weak 4.65 ERA on the season, ranking them near the bottom at 25th. The Twins have surrendered 35 runs in their last five games. It is no surprise the over is a convincing 9-1 in the Twins' past 10 games.
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