Minnesota Twins vs. Los Angeles Angels Picks and Prediction, Tuesday, September 9, 2025
On Tuesday, the Minnesota Twins will play the Los Angeles Angels at Angel Stadium, and we have you ready to go with our Twins vs. Angels prediction. First pitch from Anaheim, CA, is at 6:38 p.m. PT.
The Twins are -115 moneyline favorites, and the game total is nine runs scored.
This is the second series of the season between Minnesota and LA. The Twins swept the Angels in April and lead the series 9-1 over the last ten matchups. The total went over in six of those games. If you want the Twins vs. Angels prediction, read on and check out our MLB Predictions to beat the sportsbooks!
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Minnesota is 16-31 in the second half
Minnesota (64-80 SU, 68-76 RL, and 68-67-9 O/U) lost two of three games to Kansas City in its previous series. The Twins are 3-7 in their last ten games (the over was 7-3).
Minnesota will start right-hander Zebby Matthews tomorrow against the Angels. In his last outing, the 25-year-old surrendered one run on three hits in six innings against the White Sox. He is 4-4 with a 4.73 ERA and 1.42 WHIP in 13 starts (64.2 IP) this year, including 2-3 with a 5.77 ERA and 1.60 WHIP in seven road starts (34.1 IP).
The Twins had a solid run in May, compiling an 18-8 record, but have collapsed since then (32-54). The front office decided against investing in the ballclub at the trade deadline, making multiple trades that left Minnesota in poor shape for the final two months of the season. In other words, it's likely the Twins won't be making an appearance in the postseason in 2025.
Minnesota Twins Baseball Injury Report: No new injuries to report for Tuesday's game versus Los Angeles.
Angels have only had one winning month
Los Angeles (67-77 SU, 77-67 RL, and 78-63-3 O/U) dropped two of three games to the Athletics in its previous series. The Angels are 5-5 in their last ten games (the under was 6-4).
The Halos will start righty Kyle Hendricks on Tuesday against Minnesota. In his last outing (6.0 IP vs Kansas City), the 35-year-old allowed two runs on three hits, including two homers, and three walks. He is 6-9 with a 4.81 ERA and 1.30 WHIP in 27 starts (142.1 IP) this season, including 4-5 with a 4.74 ERA and 1.38 WHIP in 14 home starts (74.0 IP).
Los Angeles lost 99 games last season, the most in franchise history. The club has made significant strides in 2025, flirting with .500 at various points in the season. They're also 11 games over .500 against the run line. While it likely won't result in a trip to the postseason, LA has made progress.
Los Angeles Angels Baseball Injury Report: No new injuries for tomorrow's game against the Twins.
Twins vs. Angels Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Moneyline Pick for Twins vs. Angels
- Los Angeles ML -105 (5 Units)
Betting Trends: The Twins are just 28-44 (38.9%) on the road this season, the fourth-worst road record in MLB. They are 9-15 on the road since the All-Star break. The Angels are two games under .500 at home and two games over .500 in night games, as well.
I lean towards Anaheim's side in Tuesday night's game against Minnesota. Hendricks didn't fare well against the Twins in April, but that was a confident and much more talented lineup than the one taking the field this month. The Halos' starter also held the Twins to just two runs in a six-inning outing last season. While hardly dominant, Hendricks also has momentum, as he allowed just three total runs in his previous two starts (12.0 IP vs Houston and KC). Matthews has pitched a high ERA in away games and is a fly ball pitcher facing an LA ballclub that ranks third in MLB in home run/fly ball ratio against right-handers this season. They also rank 5th in wRC+ on fly balls.
Over/Under Pick for Twins vs. Angels
- Over 9 (4 Units)
Betting Trend: The over is 25-18-3 when the Angels are home underdogs this season, the highest over winning percentage of any team that has played at least 25 games as a home dog in 2025.
I lean in the over's direction in Tuesday night's game, as neither starting pitcher has pitched consistently this year. I'm willing to back Hendricks with his recent momentum as a factor, but he's unlikely to completely quiet a Minnesota team he surrendered seven runs to earlier this season. While better recently, Matthews has had some rough starts in away games and struggles to limit free passes at times. These bullpens rank among the worst in baseball (25th and 28th in ERA), as well.
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