MLB Best Bets Today – Friday, September 19 2025

By: Dean Whitaker Published 09/19/2025, 01:00 PM ET
Red Sox vs Blue Jays prediction
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After bouncing back with a 2-1 card yesterday, we’ve pushed our run to 13-5 over the last 18 MLB Best Bets. Tonight, the focus shifts to another slate full of opportunity, and we’ve locked in three plays that stand out. With sharp pitching insights, offensive trends, and matchup breakdowns, these bets are built to keep the momentum rolling and the profits stacking. The mission is clear—stay hot and keep cashing tickets on the diamond.

Below, let's take a look at some of my favorite MLB picks for today, in best bets form.

Milwaukee MLB Best Bet Gets Us Started

Milwaukee enters tonight’s NL Central clash against St. Louis with momentum and a clear advantage in both pitching and lineup depth, making them a strong pick to take the opener at Busch Stadium. Jacob Misiorowski (5–2, 4.35 ERA) gets the start for the Brewers and has held opponents to a .199 batting average this season while striking out 81 in just over 60 innings. He’s already faced the Cardinals twice, allowing just four earned runs across 10 innings, and now draws a St. Louis offense that ranks 27th in slugging and 28th in home runs.

Offensively, Milwaukee is rolling behind Christian Yelich (29 HR, 100 RBI) and Brice Turang (.289 AVG), with the Brewers winning nearly 70% of games when favored at -121 or shorter. The Cardinals, meanwhile, are missing key bats like Willson Contreras and have dropped five of their last seven. With Milwaukee’s bullpen ranking top 10 in WHIP and save conversion, and St. Louis struggling to generate late-game rallies, expect the Brewers to control tempo and close out a 5–2 win.

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Best Bet #1

  • Milwaukee -118

Scherzer Dominates Kansas City In Our 2nd MLB Best Bet

Toronto enters Friday night’s matchup at Kauffman Stadium with a clear edge behind Max Scherzer, who owns a dominant 14–5 career record and a 3.15 ERA against the Royals—including a staggering 5–0 mark with a 0.57 ERA over his last five starts versus Kansas City. Scherzer’s command and strikeout efficiency (8.5 K/9) should neutralize a Royals lineup that ranks 28th in runs per game and has gone just 2–7 in its last nine as underdogs.

Backed by a Blue Jays offense averaging five runs per game and led by Vladimir Guerrero Jr. (.300 AVG, 23 HR) and George Springer (29 HR), Toronto has won nearly 74% of games when favored at -142 or shorter. With Michael Lorenzen (5–11, 4.91 ERA) struggling and Scherzer historically lights-out in this matchup, expect the Jays to control tempo and cruise to a 6–2 win.

Best Bet #2

  • Toronto -126

Classic Pitcher's Duel Rounds Out Our Best Bets

Tonight’s AL Central showdown between Cleveland and Minnesota at Target Field sets up as a classic pitcher’s duel, making the Under 8 a strong play. Parker Messick (3–0, 1.84 ERA) has been lights-out through his first five career starts, showing elite command and limiting opponents to a .212 average. He’ll face Pablo López (5–4, 2.64 ERA), who’s been equally sharp—especially at home, where he owns a 2.70 ERA and has held Cleveland to just a 2.97 mark over his last five outings.

Both lineups rank bottom 10 in slugging and runs scored, and with cooler temps expected in Minneapolis, long balls should be limited. With two efficient starters and two struggling offenses, expect a tight, tactical battle that finishes in the 3–2 or 4–3 range—comfortably under the posted total.

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Best Bet #3

  • Cleveland/Minnesota Under 8

Recapping Today's MLB Best Bets

  • Milwaukee -118
  • Toronto -126
  • Cleveland/Minnesota Under 8

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