MLB Best Bets Today – Friday, September 5 2025
The MLB season continues to deliver excitement, drama, and plenty of betting value. While we went just 1-2 with our picks last night, we’re ready to bounce back strong. Tonight, we’ve zeroed in on three of the best opportunities on the board with our MLB best bets and predictions. Backed by pitching matchups, offensive trends, and sharp analysis, these plays are built to give you the edge and help maximize your winnings on the diamond.
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Boston Red Sox vs Arizona Diamondbacks
Boston enters tonight’s series opener at Chase Field with momentum and matchup edges that make them a strong play over Arizona. Rookie lefty Payton Tolle impressed in his debut, striking out eight and allowing just three hits over 5.1 innings, and he’ll face a Diamondbacks lineup missing key bats like Lourdes Gurriel Jr. and Pavin Smith. Arizona counters with Eduardo Rodriguez (6–8, 5.40 ERA), who’s struggled with command and owns an 8.31 ERA in two career starts against his former club. Boston’s offense, led by Trevor Story and Jarren Duran, ranks top five in runs scored and slugging, and they’ve gone 7–1 in their last eight road games. With the Red Sox pushing for a wild card spot and Arizona fading below .500, expect Boston to control the tempo and plate enough runs to back Tolle in a 6–4 win.
Milwaukee Brewers vs Pittsburgh Pirates
Milwaukee enters tonight’s matchup at PNC Park with a clear edge over Pittsburgh, backed by Quinn Priester’s consistency and a top-tier offense that ranks second in MLB in runs scored. Priester (11–2, 3.28 ERA) has delivered eight quality starts and tossed six shutout innings in his last outing against Toronto, while the Brewers have won 16 straight games he's started. The Pirates counter with Johan Oviedo (2–0, 3.60 ERA), who’s yet to pitch beyond five innings this season and faces a Brewers lineup batting .259 with a .332 OBP—both top-two marks in the league. Despite Pittsburgh’s recent home surge, Milwaukee’s depth, plate discipline, and bullpen reliability (97 holds, 67.8% save rate) should carry them to a 5–3 win and their eighth victory in the season series.
Houston Astros vs Texas Rangers (Total)
Tonight’s Astros–Rangers clash at Globe Life Field sets up as a prime spot for the Under 7.5, with two elite arms and two underperforming offenses colliding. Houston sends out Hunter Brown (10–7, 2.34 ERA), who’s held opponents to two runs or fewer in six of his last seven starts, while Texas counters with Merrill Kelly (11–7, 3.24 ERA), riding a streak of four straight quality outings and a .208 opponent batting average. Both teams rank bottom-10 in runs scored this season, and the Rangers lead MLB in team ERA (3.45). With playoff pressure mounting and both clubs trending toward low-scoring affairs—Houston is 69–64–8 to the under, Texas 77–62–2—this matchup profiles as a tight, pitcher-driven battle that finishes 3–2 either way.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,778.00 |
| 2 |  Ross Benjamin | +1,716.00 |
| 3 |  David Hess | +1,326.00 |
| 4 |  Earle Sports Bets | +1,323.00 |
| 5 |  Dan Kaiser | +1,071.00 |
The Picks Are In:
- Boston -127 over Arizona
- Milwaukee -133 over Pittsburgh
- Houston/ Texas Under 7.5
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
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