MLB Best Bets Today – Tuesday, September 16 2025

By: Dean Whitaker Published 09/16/2025, 01:00 PM ET
Rockies vs Dodgers prediction
Use Code WWWC

We’re on fire! After another sweep on Sunday, we’ve now delivered a perfect 9-0 run over our last nine plays, and the momentum is rolling. Today’s MLB slate brings three more best bets that we’ve locked in, each backed by pitching matchups, lineup trends, and sharp analysis. With confidence at its peak, this card is built to keep the streak alive and the profits stacking. Don’t miss your chance to ride the hot hand on the diamond today!

____________________________________________________________________________________________________

Miami Marlins vs Colorado Rockies

Tonight’s Marlins–Rockies matchup at Coors Field is tailor-made for offense, making Over 10 a sharp play backed by venue, pitching splits, and recent form. Miami sends out Eury Pérez (4.67 ERA), while Colorado counters with Kyle Freeland (4.97 ERA), both of whom have struggled to suppress contact and have WHIPs north of 1.30. Coors Field remains the most hitter-friendly park in baseball, and both teams feature hot bats—Mickey Moniak is coming off a 4-for-4, 2-HR, 5-RBI performance, while Miami’s Agustin Ramirez and Kyle Stowers have combined for 45 home runs on the season. The Marlins have gone Over in six of their last ten, and the Rockies have hit the Over in four of their last six at home. With shaky bullpens and power surging on both sides, expect this one to push past double digits comfortably.

____________________________________________________________________________________________________

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

Texas Rangers vs Houston Astros

Houston still offers value at +102 tonight against Texas despite Kyle Tucker being sidelined with a calf strain, thanks to a favorable pitching edge and timely hitting. A.J. Blubaugh has quietly impressed with a 2.45 ERA through four starts, showing poise and command against quality lineups. The Astros have leaned on Yordan Alvarez and Jeremy Peña to carry the offense in Tucker’s absence, and both have delivered—Alvarez with a .310 average over his last 10 games and Peña with clutch hits in late innings. Texas counters with Merrill Kelly, who’s been inconsistent on the road and vulnerable to left-handed power, which plays into Houston’s strengths. With the Astros winning five of their last seven home games and showing resilience without their star outfielder, backing Houston at plus money is a sharp play in a tightly contested AL West battle.

____________________________________________________________________________________________________

Philadelphia Phillies vs LA Dodgers

The Dodgers are a sharp play tonight over the Phillies, with Shohei Ohtani taking the mound and backed by a red-hot lineup that’s clicking at the right time. Ohtani has allowed two or fewer runs in 10 of his 12 starts this season and enters with a 3.75 ERA and 49 strikeouts over 36.2 innings. Offensively, Mookie Betts is batting .476 over his last five games with two homers and nine RBIs, while Freddie Freeman and Andy Pages have combined for 10 hits in their last five outings. The Dodgers have won five of their last nine as favorites and are 73–54 when laying -119 or more. With Cristopher Sanchez on the hill for Philly—who’s been solid but allowed four earned runs in his last outing against L.A.—the Dodgers’ power and home-field edge give them the upper hand in this playoff-caliber showdown.

____________________________________________________________________________________________________

Never Tried Winners and Whiners? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code DOLLAR
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
  • Check out more MLB predictions
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright © 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.