MLB Best Bets Today – Wednesday, September 24 2025

By: Dean Whitaker Published 09/24/2025, 12:00 PM ET
Freddie Freeman looks to lead the Dodgers over the Diamondbacks
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The grind continues with another value-packed Wednesday MLB slate. Three matchups have been circled, each backed by pitching analysis, offensive form, and matchup insights. After going 1-2 yesterday, the goal is simple—get back on track, build momentum, and keep stacking profits on the diamond.

Below, let's take a look at some of my favorite MLB picks for today, in best bets form. These just missed out on being on my premium card.

Best Bet #1 - Padres Over Brewers Gets Us Started

The Padres and Brewers square off today in a matchup that should be tightly contested, but San Diego holds the upper hand. With Dylan Cease on the mound, the Padres have a pitcher capable of missing bats and working deep enough to hand things off to a strong bullpen. Offensively, San Diego has shown more consistency down the stretch, and with playoff positioning on the line, this lineup should be fully engaged against a Brewers team that has already secured the division. Expect the Padres to come out with urgency and play with more intensity in this spot.

Milwaukee certainly has depth and an offense that can string hits together, but the situational edge goes to San Diego. Cease’s ability to limit damage, paired with the Padres’ bullpen advantage, makes it tough for the Brewers to grab control late in the game. Add in San Diego’s ability to generate timely extra-base hits, and the Padres are in position to close this one out in front of their home crowd. Padres 5, Brewers 3 feels like the right scoreline.

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Best Bet #1

  • San Diego -125

Best Bet #2 - Houston/ Athletics Play Low Scoring Game

Houston enters this matchup with a pitching edge that sets the tone for a lower-scoring game. Their starter has been effective at limiting hard contact, and the bullpen has quietly been one of the more reliable groups in the American League. On the other side, the Athletics’ lineup has been inconsistent all season, often struggling to put together rallies, especially against quality pitching. With Houston’s staff in control, it’s hard to see this turning into a slugfest.

Meanwhile, Houston’s offense has the firepower to do damage but draws a matchup against a starter who has shown flashes of competence, and the park factors here lean toward keeping scoring contained. Even if Houston pushes across a few runs early, the Athletics’ bats don’t project to hold up their end in a potential shootout. With both bullpens positioned to control the late innings, the Under 9 stands out as the right call, pointing toward a game that finishes in the 4–3 or 5–3 range.

Best Bet #2

  • Astros/Athletics Under 9

Best Bet #3 - Dodgers Get Back On Track In the Desert

The Dodgers come into this matchup with momentum and a clear advantage on the mound. Their rotation continues to give them a reliable foundation, and the bullpen, despite some inconsistencies, remains deeper and more versatile than Arizona’s. Offensively, Los Angeles has the kind of balance that can wear down a staff over nine innings, with power threats throughout the lineup capable of flipping a game in one swing. That blend of pitching depth and offensive firepower gives the Dodgers a strong path to controlling the flow of tonight’s contest.

While the Diamondbacks are still pushing hard in the playoff race, this is the type of spot where Los Angeles’ experience and talent shine through. Arizona has been streaky at the plate, often struggling to generate consistent production against upper-tier pitching. The Dodgers should be able to contain those bursts while steadily applying pressure on the opposing starter and bullpen. With playoff seeding still in play, expect Los Angeles to approach this game with focus and intensity, using their deeper lineup and sharper bullpen to close things out in the late innings.

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Best Bet #3

  • LA Dodgers -144

Recapping Today's MLB Best Bets

  • San Diego -125
  • Astros/Athletics Under 9
  • LA Dodgers -144

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