New York Mets vs. Chicago Cubs Picks and Prediction for Tuesday, September 23, 2025
Use Code WWWC It’s the opening game of a three-game series between National League squads on the diamond in the Windy City as the New York Mets travel to face the Chicago Cubs Tuesday night and we have you covered with our Mets vs. Cubs prediction. New York dropped the rubber game of a three-game set with the Nationals, falling 3-2 at home Sunday afternoon. Chicago was swept in a four-game set on the road by the Reds as they fell 1-0 in the series finale Sunday afternoon. In the first series between the teams this season, the Mets took two of three at home May 9-11. Read more about this Mets vs. Cubs prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
New York’s Freefall Continues
New York dropped their second straight and their 11th in the last 15 games as it fell in the rubber game of their three-game set against the Nationals Sunday afternoon at home. The Mets entered Monday 80-76 and stood second in the NL East, 12 games behind the Phillies for the top spot. They were tied with the Reds for the final wild card spot in the National League playoff picture. Against Washington on Sunday, New York finished with eight hits as Pete Alonso was the lone player with two. Francisco Lindor (his 28th) homered for the Mets, who went one of five with runners in scoring position in the contest. Sean Manaea (2-4) took the loss as he allowed three runs on four hits with no walks and three strikeouts over three innings of work.
David Peterson is on the bump for the Mets as he makes his 30th start of the season in this contest. He is 9-6 with a 3.98 ERA, a 1.339 WHIP, 63 walks and 149 strikeouts over 167.1 innings of work this season. Peterson took the loss in his last start, which came against the Padres last Tuesday at home. He threw five innings, allowing six runs on six hits with three walks and one strikeout in a 7-4 Mets defeat. In his last three starts, Peterson is 1-1 with a 7.63 ERA, a 1.63 WHIP, five walks and 13 strikeouts over 15.1 innings of work. Peterson makes his sixth career start against the Cubs in this contest. He is 1-2 with a 4.91 ERA, a 1.418 WHIP, 12 walks, and 20 strikeouts over 18.1 innings of work against them. Peterson is 0-1 with a 3.24 ERA, a 1.44 WHIP, five walks and 11 strikeouts over 8.1 innings in two career starts at Wrigley Field.
Cubs Looking to Secure Top Wild Card Spot in National League
Chicago sputtered on the road in a four-game road set as they were swept after falling 1-0 for the second time in the series Sunday. The Cubs entered Tuesday 88-68 and stood second in the NL Central, seven games behind the Brewers for the top spot. They held the top wild card spot in the NL playoff picture by three games over the Padres. Against the Reds Sunday, Chicago finished with six hits though no player had more than one. The Cubs were zero of seven with runners in scoring position and left nine runners on base in the game. Jameson Taillon (10-7) took the tough loss as he allowed one run on five hits with no walks and four strikeouts over seven innings of work.
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Cade Horton takes the mound for the Cubs as he makes his 23rd appearance, 22nd start, in this contest. He is 11-4 with a 2.66 ERA, a 1.096 WHIP, 33 walks and 95 strikeouts over 115 innings of work this season. Horton picked up the win in his last start, which came last Tuesday on the road against the Pirates. He threw five innings, allowing one runs on three hits with one walk and six strikeouts in a game the Cubs won 4-1. In his last three starts, Horton is 2-0 with a 1.10 ERA, a 1.08 WHIP, two walks and 14 strikeouts over 16.1 innings of work. Horton earned the win in his lone career outing against the Mets, which came in relief at Citi Field on May 10. He threw four innings, allowing three runs on four hits with no walks and five strikeouts in a game the Cubs won 6-5. Horton is 3-1 with a 1.55 ERA, a 0.955 WHIP, 14 walks and 41 strikeouts over 52.1 innings of work in 10 career starts at Wrigley Field.
Mets vs. Cubs Pick
Moneyline Pick for Mets vs. Cubs
- Cubs (4 units)
While both teams have struggled of late, the difference is that the Cubs have earned a playoff spot while the Mets find themselves even with the Reds for the final playoff spot. That means the Mets are a little more desperate at this point in time as they have let things slip away. Horton has been tremendous in the second half of the season, going 7-1 with a 0.93 ERA, a 0.789 WHIP, 15 walks and 52 strikeouts over 58.1 innings of work in 11 starts. Peterson has just two wins in nine starts since the beginning of August and he hasn’t gone more than 5.2 innings in his last five outings. Until we see the Mets put together some form of consistent play, you have to fade them given their slide. Take the Cubs at home in this contest.
Over/Under Pick for Mets vs. Cubs
- Under (4 units)
The Mets are 11th in runs per game with 4.74 runs a night, a number that edges down slightly to 4.50 runs per game on the road entering Tuesday night. New York has an average total of 9.12 runs per game and that slips to 9.09 runs per game on the road. The Mets entered Monday having seen the under post a 75-73-8 mark in their opening 156 games of the year. Chicago is eighth in the majors by averaging 4.81 runs per game while they allow an average of 4.01 runs per game, giving them an average of 8.82 runs per game. That number slips slightly to 4.71 runs at Wrigley Field, while they allow 3.97 runs, giving them an average total of 8.68 runs per game at the Friendly Confines. The Cubs have seen the under post a 74-69-13 mark on the season entering Monday afternoon. Horton has been excellent in the second half and at Wrigley Field. Take the under in this one as a result.
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