New York Mets vs San Francisco Giants Picks and Prediction for Saturday, April 4, 2026

By: Liam Keating Published 04/04/2026, 06:35 AM ET
New York Mets vs. San Francisco Giants prediction.
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The young MLB season continues with a great matchup on Saturday, April 4. Read our New York Mets vs San Francisco Giants prediction along with our other Free MLB Picks on the night. This National League clash will feature the Mets, who haven’t played to their potential in the first week of the season. The Giants are playing well, winning three of their last four games. The Mets are set to start Clay Holmes, while the Giants turn to Landen Roupp in this game. These two teams will meet with first pitch set for 9:05 P.M. EST.

Mets early season struggles continue

New York enters this weekend with a 3-4 record. The Mets opened the season by winning three of their first four games. They took the opening series over the Pirates, but they enter Friday’s game with three straight losses. Before Friday’s game, the Mets only accumulated three runs in the last three games.

Clay Holmes gets the start for the Mets in Saturday’s game. The right-handed pitcher is 1-0 after a fantastic start to the new season. He threw 5.2 innings against the Cardinals, where he allowed two runs, four hits and struck out five batters. Last year, Holmes finished with a 3.53 ERA in 33 pitching appearances. Holmes enjoyed a 3.38 ERA in 16 starts on the road last season.

The Mets have started this season with a .205 batting average, which ranks fifth-worst. They rank 21st in runs scored, while they rank 18th in hits. New York has also hit the sixth-fewest home runs on the season. Last season, the Mets hit. 249, placing them 14th. They ranked ninth-best in runs scored, while also hit the fifth-most home runs in the sport.

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San Francisco winners of 3 of last 4 games

Entering Friday’s game, the Giants are 3-4 through the first week of the season. San Francisco opened the year by being swept in three games against the Yankees at home. The Giants responded by winning three of their last four games. The Giants won twice in three games against the Padres. They started this series with a 7-2 win over the Mets on Thursday.

On Saturday, Landen Roupp gets the start for the Giants. The right-handed pitcher was fantastic in his season-opening outing. Roupp threw six innings against the Padres on March 30. He allowed two hits and zero runs in the Giants’ 3-2 win. Roupp tossed seven strikeouts, which was huge in the win. Last year, Roupp finished with a 3.80 ERA in 22 starts for San Francisco. In nine starts, Roupp threw a 2.63 ERA in home starts a season ago.

The Giants are hitting .227 through the first week of action, which ranks 16th. They have scored the third-fewest runs so far, though. San Francisco ranks 11th in hits, while they have also hit the third-fewest home runs. Last year, San Francisco hit .235, which was the sixth-worst average. The Giants did rank 17th in runs scored and 26th in hits.

New York Mets vs San Francisco Giants Picks

Mets vs Giants Spread Pick

  • Take San Francisco to cover (5 units) 

The Mets offense has simply not been consistent enough to score runs in bunches and secure a road win. They are hitting just .205 through the first week of play. San Francisco’s starting pitcher Landen Roupp is going to feast. He was great in his season opening win, as he threw six innings and allowed just two hits and zero runs in a win over the Padres. Roupp gives me confidence in a San Francisco win because he held a 2.63 home ERA last season. The Mets will not have the offensive firepower to score against Roupp in this outing.

Take the Giants to cover.

Mets vs Giants Over/Under Pick

  • Take the under (5 units)

The starting pitchers in this game looked sharp in their first start of the season. Landen Roupp dominated in six innings for the Giants, while New York’s Clay Holmes struck out five batters in 5.2 innings against the Cardinals. Holmes also held a 3.38 ERA on the road last year. With two confident starting pitchers, the two offenses for both teams, that have not played to their potential early on this season, will struggle in this game.

Take the under on Saturday. 

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