New York Yankees vs Baltimore Orioles Prediction and Picks - Saturday, September 20, 2025

By: Mike Fink Published 09/20/2025, 04:52 AM ET
New York Yankees vs Baltimore Orioles prediction
Use Code WWWC

The New York Yankees face the Baltimore Orioles with both teams on opposite ends of the standings, to close out the season. The Yankees are 86-67 and are only a handful of games back of the best record in the American League East Division while the Orioles are 72-81 and have the worst record in the division. Who will win this game? Check out our Yankees vs Orioles prediction!

When it comes to MLB picks, our MLB Predictions are stellar.

Yankees hope Rodon and lineup step up

The Yankees are having a great season and hope a strong finish earns them a top seed in the postseason. Carlos Rodon will start the upcoming game, and he looks to wrap up a great season strong, as he’s allowed only 70 runs in 182 innings pitched while tossing 190 strikeouts. Moreover, with a .214 expected opponent Batting Average, a 29.8 Whiff Rate, and a 3.29 expected ERA, opponents are making minimal contact and struggling to drive in runs against Rodon this season.

Rodon has stepped up but the lineup is the best in baseball, scoring 5.24 runs per game. Aaron Judge is slashing .328/.453/.676 with 48 home runs and 344 total bases while Giancarlo Stanton is slashing .270/.340/.572 with 20 home runs and 127 total bases but the rest of the lineup has stepped up as well. Trent Grisham is slashing .238/.347/.474 with 33 home runs and 221 total bases while Ben Rice and Jazz Chisholm Jr. have added 52 home runs and 419 total bases to round out the lineup, making the Yankees tough to put away at the plate.

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

Baltimore hopes Sugano and lineup improve

The Orioles are having a season to forget and will finish the season with the worst record in their division. Tomoyuki Sugano will start the upcoming game, and he is having an awful season, allowing 77 runs in 149 innings pitched. Moreover, with a .533 expected opponent Slugging Percentage, an 11.4 Barrel Percentage, and a 5.78 expected ERA, opponents are making hard contact and driving in runs at will against Sugano this season.

Sugano has struggled but the lineup has also been a letdown, scoring only 4.25 runs per game. Ryan O’Hearn is slashing .283/.374/.463 with 13 home runs and 144 total bases while Gunnar Henderson is slashing .273/.347/.439 with 16 home runs and 239 total bases, but the rest of the batting order has struggled. Only three active batters have an OPS+ over 100, and opposing pitchers can limit the top-heavy lineup as a result.

Yankees vs Orioles Prediction

Money Line Pick for Yankees vs. Orioles

  • Yankees -1.5 (+110) (4 Units)

The Yankees are eyeing the division title and look to take over this game from the first inning. The Yankees should drive in runs at will with Aaron Judge, Giancarlo Stanton, and the rest of the lineup making contact and putting together strong plate appearances. The Yankees should limit the Orioles' lineup, which averages only 4.25 runs per game, with Carlos Rodon, who has allowed only 70 runs in 182 innings pitched, tossing multiple scoreless innings to allow the bullpen to close out the game with a comfortable lead. The Yankees should win the game and cover the spread in a dominant win on the road.

Over/Under Pick for Yankees vs. Orioles

  • Over 9 (5 Units)

The Yankees are led by their lineup, and this game looks to be a high-scoring one from the first pitch. The Orioles should constantly plate baserunners with Ryan O’Hearn, Gunnar Henderson, and the rest of the lineup making contact and putting together strong plate appearances. The Yankees, who average 5.24 runs per game, should run up the score against Tomoyuki Sugano, who has allowed 77 runs in 149 innings pitched, with Aaron Judge, Giancarlo Stanton, Ben Rice, and the rest of the lineup swinging for the fences and crushing pitches to circle the bases at will. The Over should cover in a high-scoring game with both lineups stepping up.

Take the Over on 9 runs.

Β 

Never Tried Winners and Whiners? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code DOLLAR
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
  • Check out more MLB predictions
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.