New York Yankees vs. Boston Red Sox Prediction and Picks - September 14, 2025

The New York Yankees face the Boston Red Sox with both teams looking to wrap up great seasons in postseason position. The Yankees are 82-65 and have the second-best record in the American League East Division and are closing in on a wild card spot. The Red Sox have an 81-67 record and have the second wild card spot in the American League. Who will win this game? Check out our Yankees vs Red Sox prediction!

When it comes to MLB picks, our MLB Predictions are stellar.

Yankees hope strong lineup helps out Warren

The Yankees are having a great season and look to possibly take the division in the final weeks of the season. Will Warren will start the upcoming game, and he looks to improve on a rough season as he’s allowed 77 runs in 147 innings pitched. Moreover, with a .430 expected opponent Slugging Percentage, an 11.1 Barrel Percentage, and a 4.44 expected ERA, opponents are making hard contact and driving in runs at will against Warren this season.

Warren has struggled, but the lineup is the best in baseball, scoring 5.20 runs per game. Aaron Judge is slashing .323/.444/.673 with 47 home runs and 332 total bases as an MVP favorite, while Giancarlo Stanton is slashing .272/.348/.592 with 20 home runs and 122 total bases, but the rest of the lineup has stepped up as well. Jazz Chisholm Jr. is slashing .242/.338/.484 with 28 home runs and 198 total bases, while Trent Grisham and Ben Rice have added 53 home runs and 409 total bases to round out the lineup, making the Yankees tough to put away at the plate.

Boston looks for Crochet and lineup to end series strong

The Red Sox are having a great season and look poised to secure a spot in the postseason. Garrett Crochet is one of the reasons why, as the Cy Young hopeful has allowed only 56 runs in 185 innings pitched while tossing 228 strikeouts. Additionally, with a .221 expected opponent Batting Average, a 30.9 Strikeout Rate, and a 3.01 expected ERA, opponents are making minimal contact and struggling to drive in runs against Crochet this season.

Crochet has stepped up but the lineup has also carried this team all season, scoring 4.91 runs per game. Alex Bregman is slashing .279/.363/.473 with 16 home runs and 183 total bases, while Wilyer Abreu is slashing .253/.325/.486 with 22 home runs and 172 total bases, but the rest of the lineup has stepped up as well. Jarren Duran is slashing .257/.332/.441 with 14 home runs and 251 total base,s while Trevor Story and Carlos Narvaez have added 37 home runs and 399 total bases to round out the lineup, making the Red Sox tough to put away at the plate.

Yankees vs Red Sox prediction

Spread Pick for Yankees vs. Red Sox

• Red Sox (-110) (4 Units)

The Red Sox have their ace on the mound and look to take over this game at home. The Red Sox should constantly plate baserunners with Alex Bregman, Wilyer Abreu, and the rest of the lineup making contact and putting together strong plate appearances. The Red Sox should limit the Yankees at the plate with Garrett Crochet, who has allowed only 56 runs in 185 innings pitched, tossing multiple scoreless innings to allow the bullpen to close out the game with a comfortable lead. The Red Sox should win the game and cover the spread in a dominant win at home.

Take the Red Sox money line as home Favorites.

• Over 8.5 (5 Units)

Both teams have remarkable lineups that look to make this game a high-scoring one from the first pitch. The Yankees, who average 5.20 runs per game, should drive in runs at will with Aaron Judge, Giancarlo Stanton, and the rest of the lineup making contact and putting together strong plate appearances. The Red Sox, who average 4.91 runs per game, should run up the score against Will Warren, who has allowed 77 runs in 147 innings pitched, with Alex Bregman, Wilyer Abreu, Jarren Duran, and the rest of the batting order swinging for the fences while crushing pitches to easily circle the bases. The Over should cover in a high-scoring game controlled by both lineups.

• Take the Over on 8.5 runs.