New York Yankees vs Houston Astros Picks and Prediction for Saturday, April 25, 2026

By: David Anicetti Published 04/25/2026, 04:25 AM ET
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The New York Yankees visit the Houston Astros at Daikin Park on Saturday at 7:10 PM ET on MLB.TV. New York is 16-9, first in the AL East, while Houston is 10-16 and fifth in the AL West. The Yankees beat Boston 4-2 in their most recent game, extending their winning streak to six, while the Astros won 2-0 over Cleveland. This is the second game of a three-game series between the teams. Cash a winning ticket with our free MLB picks

Yankees Rolling with Power and Strong Pitchingย 

The Yankees are coming off a 4-2 win over Boston and have now won six straight games. New York has been dominant during this stretch, combining steady offense with an elite ERA to control games from start to finish.

New York is hitting .223 with a .322 on-base percentage and .408 slugging percentage, producing 122 runs on 181 hits. Aaron Judge leads the team with nine home runs and 17 RBI, while Ben Rice has been one of the most productive hitters in the lineup with a .311 average, eight home runs, and 18 RBI, along with a .453 OBP. Cody Bellinger is also contributing with a .271 average, giving the Yankees multiple consistent bats throughout the order.

On the mound, the Yankees have been one of the top staffs in baseball, posting a 3.07 ERA and 1.11 WHIP while allowing a .219 opponent average. The staff has recorded 219 strikeouts with just 66 walks, showing strong command and the ability to limit baserunners. That pitching consistency has been a major factor in the current winning streak.

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Injuries: Ryan Weathers, Paternity, Rafael Montero, Out, Anthony Volpe, 10-Day IL, Carlos Rodon, 15-Day IL, Gerrit Cole, 15-Day IL

Astros Relying on Offense While Pitching Struggles

The Astros are coming off a 2-0 win over Cleveland and have gone 2-3 over their last five games. Houston has had periods of strong play, but inconsistency has kept the team from building sustained momentum.

Houston is hitting .259 with a .349 on-base percentage and .434 slugging percentage, producing 137 runs on 229 hits. Yordan Alvarez has been one of the top hitters in baseball, batting .347 with 11 home runs and 26 RBI while posting a .466 OBP and .779 slugging percentage. Jose Altuve is hitting .255 with a .354 OBP, and Christian Walker has added five home runs and 18 RBI, giving the Astros a strong middle of the order.

Pitching has been the primary issue. Houston has a 5.81 ERA and 1.63 WHIP while allowing a .262 opponent average. The staff has issued 141 walks, which has created constant runners on the bases and led to high-scoring games. That lack of control has made it difficult for the Astros to protect leads even when the offense produces.

Injuries: Dustin Harris, Day-To-Day, Jeremy Pena, 10-Day IL, Zach Dezenzo, 10-Day IL, Bennett Sousa, 15-Day IL, Tatsuya Imai, 15-Day IL

Pitching Matchup

New York Yankees โ€“ Ryan Weathers

Weathers is 1-2 with a 3.18 ERA and 1.24 WHIP over 28.1 innings. He has allowed 27 hits while recording 36 strikeouts and issuing just eight walks, showing strong control and the ability to limit damage across his outings.

Houston Astros โ€“ Mike Burrows

Burrows is 1-3 with a 6.75 ERA and 1.69 WHIP across 26.2 innings. He has allowed 36 hits with 25 strikeouts and nine walks while giving up five home runs, showing continued issues with ERA.

New York Yankees vs Houston Astros Runline Pick

  • New York Yankees -1.5

The New York Yankees have the advantage due to stronger pitching and more consistent recent form. The Yankees have controlled games with their ability to limit baserunners and generate strikeouts, while Houston continues to struggle with run prevention. Even with the Astros producing at the plate, New Yorkโ€™s pitching edge and current momentum put them in a better position to win in this matchup.

New York Yankees vs Houston Astros Over/Under Pick

  • Overย 

This matchup leans toward higher scoring due to Houstonโ€™s pitching struggles. While the Yankees have been strong on the mound, the Astros' offense has the ability to generate runs, especially with Alvarez producing at a high level. With Houstonโ€™s Burrows allowing consistent contact and runners on base, New York should have multiple scoring opportunities, pushing this game over.

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