Pittsburgh Pirates vs. Cincinnati Reds Picks and Prediction for Wednesday, September 24, 2025
Use Code WWWC It’s the middle game of a series on the diamond between a pair of NL Central teams hoping to build positive momentum in the land of Skyline chili as the Pittsburgh Pirates continue a three-game set with the Cincinnati Reds Wednesday evening and we have you covered with our Pirates vs. Reds prediction. Pittsburgh took the rubber game of their three-game interleague set with the Athletics, prevailing 11-0 at home Sunday. Cincinnati swept a four-game set at home from the Cubs, prevailing 1-0 in the finale Sunday afternoon. Which team prevails in this contest? This article was published prior to the conclusion of the opening game of the series at the Great American Ball Park on Tuesday night. Read more about this Pirates vs. Reds prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Pittsburgh Playing Out the String
Pittsburgh won their second straight as it downed the Athletics in the rubber game of their interleague set at home Sunday afternoon. The Pirates entered Tuesday 67-89 and sat in the basement of the NL Central, 27.5 games behind Milwaukee for the top spot. They have been eliminated from contention in the NL playoff picture. On Sunday against the Athletics, Pittsburgh finished with 15 hits as Jared Triolo (two runs, three RBI) and Joey Bart (two runs, three RBI) each had four to lead the way. Triolo (his seventh) and Bart (his fourth) each went deep in the victory for the Pirates. Mike Burrows threw four scoreless innings, allowing five hits with no walks and three strikeouts, but didn’t factor in the decision. Carmen Mlodzinski (5-8) earned the win with three scoreless innings of relief, allowing two hits with no walks and three strikeouts.
Paul Skenes gets the call for the Pirates as he makes his 32nd start of the season in this contest. He is 10-10 with a 2.03 ERA, a 0.958 WHIP, 42 walks and 209 strikeouts over 181.2 innings of work on the year. Skenes took the loss in his last start, which came on Wednesday at home against the Cubs. He threw 3.2 innings, allowing three runs on seven hits with three walks and six strikeouts in a game the Pirates went on to drop 4-1. In his last three starts, Skenes is 1-1 with a 1.84 ERA, a 1.02 WHIP, four walks and 22 strikeouts over 14.2 innings of work. Skenes makes his fifth career start against the Reds in this contest. He is 4-0 with a 0.39 ERA, a 0.826 WHIP, two walks and 33 strikeouts over 23 innings of work against them. Skenes earned the win in his lone career start at the Great American Ball Park, which came on September 22, 2024. He threw five scoreless innings, allowing two hits with no walks and nine strikeouts in a 2-0 Pirates victory.
Reds Chasing Playoff Berth
Cincinnati won its fifth straight game as it completed a four-game sweep of the Cubs by winning the finale Sunday afternoon. The Reds went into Tuesday night 80-76 and stood third in the NL Central, 14.5 games behind the Brewers for the top spot. They were even with the Mets for the final wild card spot in the National League playoff picture. Against Chicago Sunday, Cincinnati had five hits with Gavin Lux (RBI) the lone player with two. The Reds were one of four with runners in scoring position in the game. Andrew Abbott threw 4.2 scoreless innings, allowing five hits with one walk and two strikeouts, but didn’t factor in the decision. Nick Martinez (11-13) earned the win with 2.1 scoreless innings of work, allowing no hits or walks while striking out one. Tony Santillan worked a scoreless ninth, allowing no hits with two walks and two strikeouts, for his seventh save.
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Hunter Greene takes the ball for the Reds as he makes his 19th start of the season in this contest. He is 7-4 with a 2.74 ERA, a 0.925 WHIP, 24 walks and 125 strikeouts over 101.2 innings of work this season. Greene earned the win in his last start, which came against the Cubs at home on Thursday. He threw a complete game shutout, allowing one hit with one walk and nine strikeouts in a 1-0 Reds victory. In his last three starts, Greene is 2-0 with a 2.95 ERA, a 0.71 WHIP, seven walks, and 24 strikeouts over 18.1 innings of work. Greene makes his ninth career start against the Pirates in this contest. He is 1-4 with a 2.51 ERA, a 1.00 WHIP, 17 walks and 59 strikeouts over 43 innings of work. Greene is 14-15 with a 3.50 ERA, a 1.091 WHIP, 86 walks and 301 strikeouts over 242 innings of work in 43 career starts at the Great American Ball Park.
Pirates vs. Reds Pick
Moneyline Pick for Pirates vs. Reds
- Reds (4 units)
Pittsburgh is finishing up another lost season as they failed to compete despite having Skenes leading the way on the mound. The Pirates struggled to score all season and that has impacted their record as well. Pittsburgh has scored two runs or fewer in 67 games this season, entering Tuesday, posting a 14-53 mark on the season in those games. Things won’t be any easier here for them, facing Greene, who comes in off a complete game shutout over a Cubs team that is in the postseason. Given that Cincinnati has momentum and something to play for here, look for them to pick up the win over Pittsburgh to keep in the mix for that final wild card spot as Greene shuts the Pirates down.
Over/Under Pick for Pirates vs. Reds
- Under (5 units)
Pittsburgh has seen the under post an 89-62-5 mark on the year heading into Tuesday’s action. The Pirates are 30th in the majors with 3.60 runs per game and that number falls to 3.29 runs per game away from PNC Park. Pittsburgh has an average total of 7.64 runs per game but that number barely moves to 7.72 runs per game on the road. Cincinnati entered Tuesday 14th in the majors as they average 4.47 runs per game on the season. The Reds allow an average of 4.25 runs per game, giving them an average total of 8.72 runs per contest on the year. They have averaged 4.62 runs per game at home while allowing an average of 4.19 runs per contest, giving them a total of 8.81 runs per game at the Great American Ball Park. Cincinnati has seen the under post an 89-58-9 mark in their 156 games in relation to the total on the year. With a pair of solid arms on the mound here, lean toward the under.
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