Pittsburgh Pirates vs. Milwaukee Brewers, Picks and Prediction, Saturday, April 25, 2026
Use Code WWWC Pittsburgh (15-11) will be trying to avoid their second consecutive road series loss when they visit American Family Field on Saturday night to face Milwaukee (13-12) in the second game of their three-game series at 7:10 PM. ET. Read on to find out which team picks up the win in this Pirates vs. Brewers prediction. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Mitch Keller, 2-1, 2.79 ERA, will get the start for the Pirates. The Brewers will counter with Jacob Misiorowski, 1-2, 3.04 ERA.
Milwaukee is 9-1 in its last 10 games against Pittsburgh.
Pirates Going For Series Win
The Pirates bounced back from their loss to Texas with a win over the Brewers in the first game of this series. They will try to keep the momentum going and pick up the series win when they play on Saturday.
Get Free $30 Credit for Premium Picks + Exclusive Discounts
Subscribe Now
Pittsburgh averages 4.96 runs per game, which is sixth in the league. Their .247 batting average is 11th in the league. Their .332 on base percentage is ninth, while their .386 slugging percentage is 14th.
Ryan O’Hearn leads the Pirates with a .333 batting average, while Oneil Cruz leads the team with eight home runs and 24 RBI.
Pittsburgh is giving up 3.96 runs per game, which is 10th in the league. Opponents have a .226 batting average against the Pirates, which is sixth in the league. Their 3.45 ERA is also sixth, while their 1.29 WHIP is 12th.
In his last start, Keller gave up five hits and two runs in seven innings, leading to a 6-3 win over Tampa Bay. He is 1-7 with a 5.31 ERA in 12 games against Milwaukee.
Brewers Trying To Snap Three-Game Losing Streak
The Brewers struggled over the past week, and they come into this game on a three-game losing streak. They will try to snap their streak and even up the series with a win on Saturday.
Milwaukee averages 4.96 runs per game, which is eighth in the league. Their .241 batting average is 14th in the league. Their .342 on base percentage is fourth, while their .368 slugging percentage is 23rd.
William Contreras leads Milwaukee with a .278 batting average. Gary Sanchez leads the team with five home runs, while Brice Turang leads the team with 18 RBI.
Milwaukee is giving up 4.28 runs per game, which is 12th in the league. Opponents have a .243 batting average against the Brewers, which is 18th in the league. Their 3.98 ERA is 13th, while their 1.33 WHIP is 18th.
In his last start, Misiorowski gave up four hits and three runs in five innings, leading to a 5-3 loss to Miami. He is 2-0 with a 0.75 ERA in two starts against Pittsburgh.
Pirates vs. Brewers Picks
Money Line Pick for Pirates vs. Brewers
- Milwaukee Brewers ML (4 Units)
The Brewers have the edge here because they’re playing well offensively at home. They’ve had a lot of success batting against right-handers, and Keller has been shaky on the mound, giving up seven runs in his last three starts. With Pittsburgh’s bullpen also struggling in recent games, they will have a hard time slowing down the Brewers.
Pittsburgh will have a hard time keeping up offensively because Misiorowski has done better on the mound in recent starts, giving up five runs in his last three home starts. He gave up one run in two starts against the Pirates and will keep their offense in check. Take Milwaukee on the money line.
Over/Under Pick for Pirates vs. Brewers
- Under (4 Units)
The Pirates average 4.96 runs per game. They’re batting .243 against right-handers, and they’re facing a starter who gave up five runs in his last three home starts and one run in two starts against them. The Brewers average 4.96 runs per game. They’re batting .246 against right-handers, and they’re facing a starter who gave up nine runs in his last three starts against them. Don’t expect these teams to score enough runs to push the score over the total. The Brewers and Pirates played under the total in three of their last four meetings.
Never Tried Winners and Whiners? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code DOLLAR
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
- Check out more MLB predictions
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
