Pittsburgh Pirates vs Milwaukee Brewers Picks, Prediction, Odds, and Line Movement for Friday April 24 2026

By: Kyle Kargel Published 04/24/2026, 09:18 AM ET
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Pittsburgh heads to American Family Field on April 24 for a matchup that features one of the most intriguing starting pitching duels of the night, with Paul Skenes and Brandon Woodruff both coming in on strong early-season form. Bettors scanning the night's best MLB predictions will find this Pirates vs Brewers matchup compelling because both starters carry WHIP numbers under 1.00, the team offensive profiles are extremely close, and the handicap really comes down to which lineup can squeeze out the extra run against a bullpen-and-defense grind. With Skenes giving Pittsburgh the slight edge in raw stuff and both clubs dealing with meaningful injuries, this sets up as one of the cleaner low-scoring plays on the board.

Quick Picks and Prediction

  • Spread Pick: Brewers +1.5
  • Total Pick: Under 7
  • Projected Final Score: Pirates 3, Brewers 2

Odds and Line Movement

The market on this matchup has been tight and stable, with Pittsburgh holding favorite status throughout every recent tick. The moneyline has floated between -136 and -142 for the Pirates, with Milwaukee as a short underdog at +116 to +120. That kind of narrow range suggests sharp respect for the Skenes matchup edge, and public money has been overwhelming on Milwaukee despite the price, with the ticket percentage climbing as high as 92 percent at one point. The total opened at 7 and has held at that number across the board, with the Under getting hammered at 100 percent public support on multiple ticks.

Opening Odds

Team Moneyline Total
Pittsburgh -136 Over 7 -115
Milwaukee +116 Under 7 -105

Current Odds

Team Moneyline Total
Pittsburgh -136 Over 7 -108
Milwaukee +116 Under 7 -112

Line Movement - Run Line

Date Time Pittsburgh Milwaukee
04/24 09:03:35AM -136 +116
04/23 07:26:03PM -138 +118
04/23 07:25:46PM -136 +116
04/23 04:36:35PM -142 +120
04/23 02:02:45PM -136 +116

Line Movement - Total

Date Time Over Under
04/24 08:46:30AM 7 -108 7 -112
04/23 04:39:11PM 7 -110 7 -110
04/23 02:02:45PM 7 -115 7 -105

Pirates vs Brewers Key Matchups and Handicap

Pirates

Pittsburgh's side of this handicap is anchored by Paul Skenes, who enters at 3-1 with a 3.27 ERA, a 0.91 WHIP, 22.0 innings pitched, only 13 hits allowed, 23 strikeouts, seven walks and two home runs surrendered. That 0.91 WHIP is the kind of ace-level number that defines pitchers' duels, and the strikeout rate gives the Pirates a legitimate path to limit the Brewers' run production regardless of how much contact Milwaukee generates. With only 13 hits in 22 innings, Skenes has been one of the hardest starters in baseball to square up, and that profile is especially valuable against a Milwaukee team that has built its offensive identity around contact and on-base skills rather than raw power.

The Pittsburgh lineup is not overpowering, but it does carry the slight power edge in this matchup, hitting .247 as a team with 123 runs scored, 214 hits, 28 home runs, a .332 OBP and a .386 slugging percentage. Oneil Cruz has been the headliner with eight home runs, 23 RBI and a .284 average, giving the Pirates a true game-changing bat in the middle of the order. Ryan O'Hearn has been exceptional at .325 with a .417 OBP and a .513 slugging percentage, providing high-end on-base production that can set up Cruz for run-scoring opportunities. Against Woodruff's tight command profile, the Pirates will have to take advantage of their limited scoring chances, but Cruz and O'Hearn represent the kind of bats capable of producing a one-swing run.

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Brewers

Milwaukee counters with Brandon Woodruff, who has been nearly as sharp as Skenes early in the season, going 2-0 with a 3.42 ERA, a 0.93 WHIP, 23.2 innings pitched, 18 hits allowed, 20 strikeouts, only four walks and three home runs allowed. The walk total is especially notable because Woodruff has shown excellent command in his return, and the 0.93 WHIP means he has been allowing fewer than one baserunner per inning. Against a Pittsburgh offense that relies heavily on Cruz and O'Hearn, Woodruff's ability to avoid giving up free bases through walks is the kind of skill that keeps big innings from developing. The one concern is the three home runs in 23.2 innings, which creates a narrow but real path for Cruz to do some damage.

The Brewers offense has some quality individual contributors despite the team's modest .241 average and .368 slugging percentage, with a .342 OBP that is actually a slight edge over Pittsburgh's .332. William Contreras leads the way at .302 with a .381 OBP and a .453 slugging mark, Brice Turang has driven in 18 runs with four home runs and a .280 average, and Gary Sanchez provides secondary power with five home runs and 13 RBI. The Brewers' challenge is that their on-base profile does not translate cleanly against Skenes, who has allowed only 13 hits in 22 innings and has the kind of strikeout ability that shuts down contact-based offenses. Contreras and Turang will need to find a way to put together one big inning, which is why the +1.5 spread makes the most sense as the side angle rather than the moneyline in this spot.

Recent form is almost identical for these two teams, with both clubs winning only two of their last five games, but the direction of the momentum is slightly worse for Milwaukee, which has dropped two straight, while Pittsburgh is coming off a 6-1 loss at Texas that does not reflect poorly on the offensive capability. The head-to-head trend strongly supports the Under, with both starters carrying sub-1.00 WHIPs and ERAs in the low 3s, a combination that historically produces low-scoring games. Public money has been heavy on Milwaukee at the 92 percent level, and the Under has been backed at 100 percent on multiple recent ticks, which reinforces the idea that the market recognizes this as a pitching-heavy spot. The Pirates' power edge and Skenes' elite WHIP give Pittsburgh the cleaner path to a tight win.

Key Injuries and Notes - PIT vs MIL

Pittsburgh is missing Dominic Fletcher, Anthony Solometo, Jared Triolo, Jared Jones and Sean Sullivan, which affects outfield, infield and pitching depth but does not significantly alter the top of the lineup or the Skenes start. Milwaukee's injury list is equally long and arguably more impactful, with J.B. Bukauskas, Jackson Chourio, Jared Koenig, Quinn Priester and Andrew Vaughn all sidelined. Chourio's absence is the most damaging for the Brewers because it removes a key athletic piece from the lineup and lowers the overall ceiling of the offense at a time when Milwaukee needs every possible run-producing option against Skenes. The combination of both teams carrying meaningful depth concerns reinforces the low-scoring projection, with neither bullpen at full strength if the game turns into a bridge situation in the seventh and eighth innings.

Pirates vs Brewers ATS and Total Picks

  • Against the Spread: Brewers +1.5 is the preferred side play, supported by Woodruff's 0.93 WHIP giving Milwaukee a real chance to keep the game close, the tight pitching matchup creating a narrow margin, and the Pirates being more likely to win by a single run than by multiple runs.
  • Total: Under 7 is the lean, backed by Skenes' 0.91 WHIP, Woodruff's 0.93 WHIP, both starters posting ERAs in the low 3s, and 100 percent public money hammering the Under on multiple consecutive ticks.

Final Score Prediction

The projected final score is Pirates 3, Brewers 2. Both Skenes and Woodruff should dominate the first six innings, keeping the score low and forcing bullpen-and-defense execution to decide the outcome. Pittsburgh's slight power advantage through Cruz and O'Hearn, combined with Skenes' ability to produce extra strikeouts in key spots, should be enough to eke out a narrow one-run win. Five total projected runs comfortably clears the Under 7 number, and a one-run Pirates win keeps Milwaukee alive on the +1.5 spread, giving bettors a scenario where the Brewers run line, the Pirates moneyline and the Under can all cash together in this Pirates vs Brewers matchup.

How to Bet Pirates vs Brewers

For bettors looking to get action on this Pirates vs Brewers matchup, there are several strong options depending on your state and preferred platform. If legal online sportsbooks are not available in your area or you want a free-to-play alternative, social sportsbooks offer a solid way to get involved with MLB betting through promotional coins and daily rewards that work well on a low-scoring pitchers' duel like this one. Bettors in legal states looking for competitive pitching-matchup markets and strong Under pricing should consider the bet365 bonus code, which pairs well with a game like this where the Pirates moneyline, Brewers +1.5 and Under 7 are all viable plays. Another strong option is the fliff promo code, which unlocks bonus coins that can be applied across moneylines, run lines, totals and strikeout props, giving bettors the flexibility to shop Skenes and Woodruff strikeout markets alongside the primary sides and totals in this Pirates vs Brewers matchup.

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