San Diego Padres vs Arizona Diamondbacks Picks and Predictions for Saturday April 25 2026
Use Code WWWC The San Diego Padres will be in Mexico City Saturday night for a 6:05 PM matchup against the Arizona Diamondbacks in game 1 of a 2-game Mexico City series, and we have you ready to roll with our San Diego vs Arizona prediction. San Diego comes into the weekend with 17 wins and 8 losses on the year, having won 4 of the last 5 following a 2-run road victory against the Colorado Rockies. The Arizona Diamondbacks come into this matchup with 14 wins and 11 losses, having dropped 3 of the last 4 after a 3-run loss to the Chicago White Sox. Read more about this San Diego vs Arizona prediction! Struggling with handicapping? Try our MLB Predictions!
San Diego looks to keep it rolling
The San Diego offense has been mediocre this season, with a .234 batting average. The Padres have scored 110 runs on 194 hits. San Diego has a .310 OBP and a .372 team slugging percentage. San Diego has compiled a 3.62 team ERA this season, but has allowed 10 total runs across their last 4 wins. Matt Waldron got the start for San Diego in their last outing, giving up 6 runs on 8 hits across 5 innings of work. Ron Marinaccio came on in relief, giving up 1 run on 4 hits across 2 innings of work, leading to the victory. Miguel Andujar and Gavin Sheets led the show for the San Diego offense in their last outing, driving in 3 runs apiece.
Xander Bogaerts leads the San Diego offense this season with a .289 batting average and 4 home runs. Fernando Tatis Jr. has a .250 batting average, and Miguel Andujar has a .316 batting average, but he has played just 17 times this season. Ramon Laureano has a .264 batting average to go along with a team-leading 17 RBI's.
Key Injury Report for San Diego:
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Yuki Matsui (15-Day IL)
Blake Hunt (7-Day IL)
Will Wagner (10-Day IL)
Jeremiah Estrada (15-Day IL)
Griffin Canning (15-Day IL)
Arizona tries to get back on track
Offensively, Arizona has been solid enough this season, with a .251 batting average. The team has scored 116 runs on 208 hits. Arizona has a .306 OBP and a .417 team slugging percentage. Arizona has a 4.41 team ERA this season have given up 25 total runs over their last 3 losses. Mike Soroka got the start for Arizona last time out, giving up 1 run on 7 hits across 5 innings of work, resulting in a no-decision. Paul Sewald came on in relief to give up 3 runs on 1 hit after recording just 2 outs, leading to the loss.
Corbin Carroll leads the Arizona offense this season with a .296 batting average and 17 RBI's. Nolan Arrenado has a .262 batting average, and Geraldo Perdomo has a .259 batting average. Ildemaro Vargas has a .357 batting average and leads Arizona with 5 home runs this season.
Key Injury Report for Arizona:
- Carlos Santana (10-Day IL)
- Gabriel Moreno (10- Day IL)
- Tyler Locklear (10-Day IL)
- Pavin Smith (60-Day IL)
- Cristian Mena (60-Day IL)
San Diego vs Arizona Pick
- San Diego vs Arizona Spread Pick
The San Diego Padres have already emerged as one of the better teams in baseball heading into Saturday, but Arizona will have the edge. Arizona has also played well this season and comes into this matchup with the better pitcher on the mound and the better offense on the field. Look for Arizona to use its edge on both sides of the dish to stifle a division rival in this matchup. Take the Diamondbacks on Saturday to do the job as they get the win against the San Diego Padres
- San Diego vs Arizona Over/Under Pick
Both teams have solid pitchers on the mound despite each having good enough offenses. Look for a pitchers’ duel to break out of this matchup as each pitcher gets it going Saturday in Mexico. Look for balls that struggle in the air as both pitchers will be on their game Saturday afternoon. Take the under on Saturday in this matchup in Mexico City.
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