San Diego Padres vs Arizona Diamondbacks Picks and Predictions for Sunday, April 26, 2026

By: Cameron Ross Published 04/26/2026, 04:00 AM ET
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The San Diego Padres will remain on the road Sunday afternoon with game 2 of 2 in Mexico City against the Arizona Diamondbacks, and we have you ready to roll with our San Diego vs Arizona prediction. San Diego has 17 wins and 8 losses thus far this season, coming into their Mexico City series. Arizona has been up and down this season, with 14 wins and 11 losses, and has lost 3 of its last 4 games. Read more about this San Diego vs Arizona prediction! Struggling with handicapping? Try our MLB Predictions!

San Diego looks to keep it rolling

San Diego has been a mediocre offensive team this season, with a .234 batting average. The Padres have scored 110 runs on 194 hits. The San Diego Padres power has been up and down as they have 20 home runs and a .372 team slugging percentage. The San Diego pitching has been solid, with a 3.62 team ERA, but the Padres have given up 10 total runs across their last 4 wins. Miguel Andujar and Gavin Sheets led the way for San Diego in their last game, driving in 3 runs each. Xander Bogaerts and Ramon Laureano chipped in as well, driving in 2 runs apiece.

Xander Bogaerts leads the San Diego offense this season with a .289 batting average, 4 home runs, and 26 hits. Fernando Tatis Jr. has been vital for San Diego with a .250 batting average this season. Ramon Laureano leads the team with 17 RBI's along with a .264 batting average. Manny Machado has struggled immensely this season with a .195 batting average, while Jake Cronenworth has also struggled with a .167 batting average after compiling only 13 hits through his first 78 at-bats this season.

Key Injury Report for San Diego:

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  • Yuki Matsui (15-Day IL)
  • Blake Hunt (7-Day IL)
  • Will Wagner (10-Day IL)
  • Jeremiah Estrada (15-Day IL)
  • Griffin Canning (15-Day IL)

Arizona tries to return to form

Arizona has been solid on offense this season, with a .251 team batting average, scoring 116 runs on 208 hits. Arizona has a .417 slugging percentage along with 23 home runs as a team. The Arizona pitching staff has been the team's biggest issue, with a 4.41 team ERA this season. Adrian Del Castillo was the only spark in the Arizona lineup in their last game, going 1-4 from the plate to drive in the lone run of the game.

Corbin Carroll is the offensive leader this season for Arizona with a .296 batting average and 17 RBIs. Nolan Arenado has been vital for the team with a .262 batting average, and Ketel Marte has a .240 batting average. Ildemaro Vargas has a .357 batting average this season for Arizona and leads the team with 5 home runs. Gabriel Moreno has a .275 batting average, but he has played just 13 times this season.

Key Injury Report for Arizona:

  • Carlos Santana (10-Day IL)
  • Gabriel Moreno (10- Day IL)
  • Tyler Locklear (10-Day IL)
  • Pavin Smith (60-Day IL)
  • Cristian Mena (60-Day IL)

San Diego vs Arizona Pick

  • San Diego vs Arizona Spread Pick

The Padres will have a huge edge on Sunday with the far superior pitcher on the mound. Look for Michael King to do the job against Arizona on Sunday, leading to the victory. The San Diego Padres will close their series in Mexico on Sunday afternoon with a win against the Arizona Diamondbacks in a divisional game.

  • San Diego vs Arizona Over/Under Pick

Both offenses have been up and down thus far this season, but the Arizona lineup will struggle in this matchup. San Diego is going to find success against a struggling pitcher, but the San Diego pitching will do the job in this matchup. Take the under Sunday as Arizona will struggle from the opening pitches at the dish as they struggle to score in game 2 of 2 of this series.

 

This prediction was written before the completion of game play on Saturday

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