San Diego Padres vs Boston Red Sox Picks and Predictions for Saturday, April 4, 2026

By: Cameron Ross Published 04/04/2026, 05:30 AM ET
Rays vs Red Sox Prediction
Use Code WWWC

The San Diego Padres will again be on the road Saturday with another game in Boston inside Fenway Park at 4:10 PM against the Boston Red Sox, and we have you ready to roll with our San Diego vs Boston prediction. San Diego enters this matchup with just two wins in seven games this season. The Boston Red Sox stay home Saturday with two wins and five losses this year. San Diego has struggled of late, losing 3 of the last 4, following a three-run loss in Game 1 of this series. Boston has struggled to mislead, losing 4 of the last 5 after the win in Game 1 of this series, which ended a lengthy losing streak. Read more about thisΒ San Diego vs BostonΒ prediction! Struggling with handicapping? Try ourΒ MLB Predictions!

San Diego looks for a positive

The San Diego offense has been terrible this season, with a .202 batting average. The Padres have scored just nineteen runs on 39 hits. San Diego has a .280 OBP and a .301 slugging percentage this season. Michael King got the start and took the loss for San Diego in Game 1 of this series, giving up four runs on seven hits across 5.2 innings of work. The San Diego bullpen combined to give up one run on two hits over the final 2.1 innings of the game. Gavin Sheets provided the only spark of the day for San Diego with two hits and three at-bats to drive in one run.

Ramon Laureano leads the San Diego offense this season with a .318 batting average, two home runs, and four RBI's. Jackson Merrill has struggled immensely this season with a .185 batting average, and Xander Bogaerts has been even worse with a .143 batting average. Fernando Tatis Jr has a .200 batting average, and Manny Machado has a .227 batting average this season.

Key Injury Report for San Diego:

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.
  • Blake Hunt (Day-To-Day)
  • Jason Adam (15-Day IL)
  • Yuki Matsui (15-Day IL
  • Sung-Mun Song (10-Day IL)
  • Matt Waldron (15-Day IL)

Boston goes for 2 in a row

Offensively, Boston has been bad this season with a .208 batting average. The Red Sox have scored seventeen runs on 42 hits this season to go along with a .295 OBP and a .347 slugging percentage. Sonny Gray got the start and won for Boston in game 1 of this series, giving up two runs on four hits across 6 innings. The Boston bullpen combined to give up no runs on no hits over the final three innings of the game. Marcelo Mayer led the way for the Boston offense with two hits and two at-bats to drive in two total runs. Three other Boston players chipped in, driving in one run apiece.

Wilyer Abreu leads the Boston offense this season with a .393 batting average, three home runs, and six RBI's. Marcelo Mayer has drifted heavily this season with a .294 batting average, and Ceddane Rafaela has added a .227 batting average this season. Connor Wong has a .500 batting average this season, but he has played in just four games.

Key Injury Report for Boston:

  • Garrett Whitlock (Paternity)
  • Anthobny Seigler (10-Day IL)
  • Joahn Oviedo (15-Day IL)
  • Patrick Sandoval (15-Day IL)
  • Kutter Crawford (15-Day IL)

San Diego vs Boston Pick

  • San Diego vs Boston Spread Pick

Both teams have struggled to start the season, but Boston will have the edge in this matchup. Boston has the better overall offense and the better pitcher on the mound. Look for the Red Sox to bounce back and get rolling in this matchup. Expect the Red Sox to control this game from the opening pitches, leading 2 the win Saturday afternoon.

  • San Diego vs Boston Over/Under Pick

Both are terrible offensively, and that will carry into this matchup. Despite both teams putting bad pitchers on the mound, each offense will continue to have its issues. Expect another offensive struggle from each team Saturday as runs come at a premium. Take the under on Saturday night in Boston as the San Diego Padres visit the Red Sox.

Never Tried Winners and Whiners? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code DOLLAR
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
  • Check out more MLB predictions
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.