San Diego Padres vs Boston Red Sox Picks and Predictions for Sunday, April 5, 2026

By: Cameron Ross Published 04/05/2026, 06:45 AM ET
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The San Diego Padres will remain on the road Sunday afternoon with the 1:35 PM matchup inside Fenway Park in Boston, MA, against the Boston Red Sox, and we have you ready to roll with our San Diego vs Boston prediction. San Diego comes into this matchup with just two wins in their first seven games. Boston stays home Sunday with two wins and five losses this season. San Diego has lost three of the last five games played following the three-run road loss to Boston in Game 1 of this set. Boston has lost 4 of the last five following their win in Game 1 of this matchup. Read more about thisΒ San Diego vs Boston prediction! Struggling with handicapping? Try ourΒ MLB Predictions!

San Diego looks to end the issues

Offensively, San Diego has been terrible this season with a .192 team batting average. The Padres scored just 21 runs on 43 hits to go along with a 264 OBP and a .290 slugging percentage. The Padres’ pitching has been just as bad, with a 4.21 team ERA. Michael King got the star and took the loss for San Diego in their last outing, giving up four runs on seven hits across 5.2 innings of work. The San Diego bullpen allowed one run on two hits over the final 2.1 innings of the game. Gavin Sheets and Luis Campusano led the way for the San Diego offense, driving in one run apiece.

Ramon Laureano leads the city of offense this season with a .308 batting average, two home runs, and five RBI's. Fernando Tatis Jr. has a .200 batting average, and Miguel Andujar has posted a .300 batting average this season. Manny Machado has a .217 batting average thus far this year.

Key Injury Report for San Diego:

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  • Blake Hunt (Day-To-Day)
  • Jason Adam (15-Day IL)
  • Yuki Matsui (15-Day IL)
  • Sung-Muh Song (10-Day IL)
  • Matt Waldron (15-Day IL)

Boston goes for 2 in a row

Offensively, Boston has been terrible this season, with a .219 team batting average. The Red Sox have scored just 22 runs on 51 hits. Boston has a .297 team OBP, and they have a .373 slugging percentage. The Boston pitching has been horrendous as well, with a 4.48 team ERA this season. Β Sonny Gray got the start and took the win for Boston last time mountain, giving up two runs on four hits across 6 innings of work. The Boston bullpen was fantastic, giving up no runs on no hits in the final three innings. Marcelo Mayer led the Boston offense in their last outing with two hits and two at-bats to drive in two runs. Three other Boston players chipped in heavily, driving in one run apiece.

Wilyer Abreu leads the Boston offense this season with a .387 batting average, three home runs, and six RBI's. Pierre Trevor's story struggled immensely this season with a .108 batting average, and Jared Duran has added a .200 batting average. Carlos Narvaez has a .333 batting average, and Connor Wong has a .500 batting average this year, but he's played just four games.

Key Injury Report for Boston:

  • Garrett Whitlock (Paternity)
  • Anthony Seigler (10-Day IL)
  • Johan Oviedo (15-Day IL)
  • Patrick Sandoval (15-Day IL)
  • Kutter Crwaford (15-Day IL)

San Diego vs Boston Pick

  • San Diego vs Boston Spread Pick

Both teams are struggling immensely coming into this matchup, as each is desperate for a win. Look for Boston to weather the storm in this game as they lean heavily on their home crowd. The Red Sox will jump out early and do the work from the opening pitches, leading to a needed victory over a struggling San Diego team. Take Boston on Sunday afternoon to do the job as they get the win at home against San Diego.

San Diego vs Boston Over/Under Pick

Both teams have struggling pitchers on the mound, but each has a terrible offense. Look for each offense to continue struggling in this matchup, as runs will come at a premium. Take the under on Sunday afternoon as the Boston Celtics do the work to get the win at home against San Diego.

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