San Diego Padres vs. Chicago White Sox, Picks and Prediction, Friday, September 19, 2025
Use Code WWWC San Diego (83-69) will be trying to take the series lead when they visit Rate Field on Friday night to face Chicago (57-96) in the first game of their three-game interleague series at 7:40 PM. ET. Read on to find out which team picks up the win in this Padres vs. White Sox prediction. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Dylan Cease, 8-11, 4.59 ERA, will get the start for the White Sox. The Padres will counter with Davis Martin, 6-10, 4.01 ERA.
San Diego is 7-3 in its last 10 games against Chicago.
**This preview was written before Thursday’s game was played.**
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San Diego Trying To Keep NL West Title Hopes Alive
The Padres played well over the past week, and they’ve won four of their last six games. They are second in the NL West standings, two games behind Los Angeles, and will try to cut into Los Angeles’ lead with a win on Friday.
San Diego averages 4.26 runs per game, which is 26th in the league. Their .252 batting average is ninth in the league. Their .322 on base percentage is 10th, while their .390 slugging percentage is 22nd.
Luis Arraez leads San Diego with a .287 batting average, while Manny Machado leads the team with 26 home runs and 92 RBI.
San Diego is giving up 3.88 runs per game, which is second in the league. Opponents have a .226 batting average against the Padres, which leads the league. Their 3.67 ERA is third, as is their 1.20 WHIP.
In his last start, Cease gave up five hits and one run in six innings, leading to an 11-3 win over Colorado.
Chicago Trying To Snap Six-Game Losing Streak
The White Sox didn’t play well over the past week, and they come into this game on a six-game losing streak. They will try to put an end to their streak and take the series lead with a win on Friday.
Chicago averages four runs per game, which is 26th in the league. Their .233 batting average is 27th in the league. Their .302 on base percentage is also 27th, while their .373 slugging percentage is 28th.
Lenyn Sosa leads Chicago with a .261 batting average and 70 RBI, while Andrew Benintendi leads the team with 20 home runs.
Chicago is giving up 4.56 runs per game, which is 20th in the league. Opponents have a .247 batting average against the White Sox, which is 20th in the league. Their 4.23 ERA is also 20th, while their 1.35 WHIP is 25th.
In his last start, Martin gave up five hits and two runs in five innings, leading to a 3-1 loss to Cleveland.
San Diego vs. Chicago Pick
Run Line Pick for San Diego vs. Chicago
- San Diego Padres ML (4 Units)
The Padres have won four of their last six games, while the White Sox have lost six straight games. San Diego has the edge here because they’ve had a lot of success batting against right-handers, and they’re going up against Martin, who was shaky on the mound in recent starts, giving up nine runs in his last three starts. He also gave up nine runs in his last three home starts, so expect him to have a hard time slowing down the Padres.
Chicago won’t be as successful offensively because they’ve struggled against right-handers, and they’re going up against Cease, who did a good job on the mound in recent starts, giving up four runs in his last three starts. With San Diego’s bullpen also playing well, they won't have trouble keeping Chicago’s offense in check. Take San Diego on the run line.
Over/Under Pick for San Diego vs. Chicago
- Under (4 Units)
The White Sox played under the total in five of their last six games. Chicago averages four runs per game and averaged 3.33 runs per game in their last three games. They’re batting .228 against right-handers, and they’re facing a starter who gave up four runs in his last three starts. The Padres average 4.26 runs per game and 4.36 runs per game on the road. They’re batting .256 against right-handers, and they’re facing a starter who gave up nine runs in his last three starts. Don’t expect these teams to score enough runs to push the score over the total. The Padres and White Sox played under the total in six of their last seven meetings.
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