San Diego Padres vs. Chicago White Sox Picks and Prediction, Sunday, September 21, 2025
Use Code WWWC It’s an intraleague battle to close out the weekend on Sunday, Sept. 21. Read our San Diego Padres vs Chicago White Sox prediction along with our other MLB Predictions to beat the sportsbooks! The Padres are in second place in the division and they hold a wild card spot in the National League. San Diego has lost three of their last five games. The White Sox continue to be the worst team in the American League. They have lost seven of their last eight games, too. The White Sox are starting Sean Burke, while Michael King gets the nod for the Padres. These two teams will meet with first pitch set for 2:10 P.M. EST.
San Diego closing in on wild card berth
San Diego is 84-71 overall this season. They are in second place in the National League West division. The Padres are 3.5 games back of the Dodgers for the divisional crown. They are also the No. 2 wild card spot. The Padres have a five-game lead over the field for a postseason berth. San Diego is 37-43 when playing on the road this year. They have lost three of their last five games. In their last game, the Padres defeated Chicago 7-3 on the road on Saturday, Sept. 20.
Michael King starts for the Padres against the White Sox. The right-handed pitcher is 4-3 with a 3.84 ERA in 13 starts. His last start saw hi throw three innings against the Mets. He allowed eight runs and 10 hits in an 8-3 loss. The Padres are 6-7 when King has started this year. They are also 1-3 when he has pitched on the road. King has a 6.64 ERA when pitching on the road and a 10.80 ERA in three games since the All-Star break.
The Padres are hitting .252 this season which ranks seventh in the league. They have scored the 18th most runs and they rank 14th in hits. San Diego has hit the second fewest home runs while they have struck out the third fewest times. San Diego has a .256 batting average when pitching on the road and a .262 batting average since the All-Star break. San Diego has a .250 average in September and a .246 batting average against American League teams.
Get Free $30 Credit for Premium Picks + Exclusive Discounts
Subscribe Now
Chicago’s poor season finally coming to a close
Chicago is 58-97 overall this season. They are in last place in the American League Central division and they have the worst record in the American League, too. The White Sox have been towards the bottom of the standings for the entirety of the season. Chicago has lost seven of their last eight games coming into Sunday’s matchup.
On Sunday, Sean Burke gets the start for the White Sox against the Padres. The right-handed pitcher is 4-10 with a 4.29 ERA in 21 stars and five relief appearances. His last start saw him throw four innings against the Orioles on Sept. 15. He allowed one run and two hits in a 4-1 loss. The White Sox are 9-17 when Burke has started this season. Burke has a 3.93 ERA when pitching at home and he has a 4.03 ERA since the All-star break. In seven starts, Burke has a 2.52 ERA against National League teams.
The White Sox are hitting .233 this season, which ranks fourth-worst. They have scored the fifth fewest runs while they rank fourth worst in hits. Chicago has hit the eighth fewest home runs, while they have also hit the sixth fewest doubles. Chicago is hitting .231 when playing at home and .253 since the All-Star break. The White Sox have a .229 batting average this month and .250 against National League clubs.
Padres vs White Sox Picks
San Diego Padres vs Chicago White Sox Spread Pick
- San Diego Padres -1.5 (5 units)
The Padres are closing in on reaching the playoffs as a National League wild card team. They are still in contention for the division, but the Dodgers are starting to pull away from San Diego. That won’t matter for Sunday’s outcome with San Diego cruising to an easy win. The Padres are hitting .246 against American League teams and the have a .250 average this month. The White Sox continue to be one of the worst teams in the sport and they have lost seven of their last eight games. They also have a .229 batting average in September which won’t be good enough in a high scoring game.
Take the Padres to cover.
San Diego Padres vs Chicago White Sox Over/Under Pick
- Over 8.5 runs (5 units)
The White Sox are set to start Sean Burke, who has a 4.03 ERA since the All-Star break. The Padres are starting Michael King, who has a 6.64 ERA when pitching on the road and an ERA of 10.80 since the All-Star break. The two pitchers have not been good enough recently, and the two offenses should feast with a high-scoring game.
Take the over on Sunday.
Never Tried Winners and Whiners? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code DOLLAR
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
- Check out more MLB predictions
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
