San Francisco Giants vs. Arizona Diamondbacks Picks and Prediction for Tuesday, September 16th, 2025
Use Code WWWC The San Francisco Giants (75-74, 68-81 RL, 71-72-6 O/U take on the Arizona Diamondbacks (75-75, 74-76 RL, 72-69-9 O/U) in the second of a three-game divisional series on Tuesday evening, and we have the prediction. The Giants have yet to name a starting pitcher for this game. The Diamondbacks will reply with Eduardo Rodriguez. The season series is 5-5.
Can the Diamondbacks catch the Giants in the standings with a home win on Tuesday? Keep reading for the Giants vs. Diamondbacks prediction. Nobody does it better when it comes to MLB Picks!
Giants Continue to Target Wildcard
The Giants have yet to name a pitcher for Tuesday evening, meaning it's probably a bullpen game. This is Carson Seymour's spot. The rookie has issued a 5.23 ERA and a 1.48 WHIP, accompanied by a 1-3 record in 31 innings of work. Spencer Bivens could pitch bulk innings.. He has kept Arizona to just two runs in 7.2 innings this season. The righty has posted a 4.10 ERA and a 1.39 WHIP in 74.2 innings of work on the season. Tristen Beck and JT Brubaker are also candidates to pitch this bullpen game. Beck has a 4.88 ERA and a strong 1.10 WHIP on the season. Brubaker has been a starter for a good portion of his career. The veteran has a 4.03 ERA and a 1.25 WHIP in 22.1 innings of work.
The San Francisco Giants appeared out of contention in the wildcard just a few weeks ago, but have won five of their past six series and are now only 1.5 games out entering Monday evening. The Giants won a home series against this Diamondbacks squad last week and dropped two of three home games against the Dodgers this week, squandering 21 runs. The Giants are 37-37 on the road.
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Heliot Ramos has a weak .535 OPS this month. The 26-year-old is having a decent season, bashing 17 home runs with 61 RBIs and a .732 OPS. Wilmer Flores has not been playing every game due to his inconsistency. The veteran first baseman has 16 home runs with 68 RBIs on the year. Matt Chapman has five RBIs and a.908 OPS against the Diamondbacks this season. The veteran third baseman has bashed 21 homers with 57 RBIs. Patrick Bailey has a sharp 1.00 OPS this month. The 26-year-old catcher has weak numbers, amassing 52 RBIs and a .630 OPS.
San Francisco is averaging 4.37 runs on the year, marking them 15th. The pitching staff has issued a 3.85 ERA, placing them eighth.
Rodriguez On the Mound on Tuesday
Eduardo Rodriguez will be on the mound on Tuesday. Rodriguez was dominant in his recent outing, pitching 6.1 scoreless innings against San Francisco and earned the win. The veteran has been outstanding this month, yielding just one run in his past 12.1 innings of work, but is having a shaky season, posting a 4.98 ERA and a 1.55 WHIP accompanied by an 8-8 record in 137.1 innings of work. Rodriguez has a subpar 4.29 ERA and a 2-1 record in 21 career innings against San Francisco.
The Arizona Diamondbacks are striving for a wildcard spot. They were out of contention just a few weeks ago, but have enjoyed a strong few weeks and are two games behind the Mets for the last wildcard spot. It has been an inconsistent season for a roster with talent. Arizona lost the series against the Giants last week and rebounded with a series win in Minnesota on the weekend, scoring 19 runs and conceding only 15 runs. The Diamondbacks are 38-34 at home.
Blaze Alexander has issued six RBIs this month. The 26-year-old has 24 RBIs and a .750 OPS. Ketel Marie has posted five RBIs in September. The 25-year-old second baseman is having another outstanding season, bashing 25 home runs with 65 RBIs on the year. Lourdes Gurriel Jr is out for he remainder of the season. Jake McCarthy has stepped up with seven RBIs this month. The veteran has 19 RBIs and a .590 OPS. Tim Tawa is getting playing time due to the injuries. He has 16 RBIs in 65 games.
Arizona is scoring an average of 4.95 runs per game, good for fifth. The pitching staff has a subpar 4.47 ERA, positioning them 22nd.
Diamondbacks vs. Giants Picks
Spread Pick for Diamondbacks vs. Giants
- San Francisco Giants ML (5 units)
The San Francisco Giants are a desperate squad. They are only 1.5 games behind the Mets for the last wildcard spot. They have won four of their past six series and are 6-2 in their past eight road games. The Arizona Diamondbacks just played against the Giants last week and dropped two of three games. The Diamondbacks were outscored by a wide 19-11 margin in that series.
Furthermore, Diamondbacks pitcher Eduardo Rodriguez has a subpar 4.29 ERA in his career against San Francisco. The veteran has especially struggled at home, where he has registered a 5.28 ERA on the season. Arizona is playing without Gurriel Jr., who leads the squad in RBIs. If this game comes down to the bullpens in the late innings, the Giants have the massive advantage. The Giants' bullpen is second in the big leagues with a 3.40 ERA, while the Diamondbacks' bullpen is rated 28th.
Over/Under Pick for Giants vs. Diamondbacks
- Over (5 units)
I expect this one to have offense. San Francisco has averaged 5.4 runs against the Diamondbacks this season. The offense has been raking this month, averaging 5.6 runs in their past ten games. The Diamondbacks have squandered 34 runs in their last six games.
In addition, despite injuries, Arizona is finding ways to score runs. Arizona has scored five or more runs in six of its past eight games entering Monday evening. They have scored 32 runs in their past six home games. The Giants haven't named a starter, and it should be a bullpen game. The over is 5-2 in the Diamondbacks' past seven games.
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