San Francisco Giants vs. Arizona Diamondbacks Picks and Prediction for Wednesday, September 17th, 2025
Use Code WWWC The San Francisco Giants (75-75, 75-76 RL, 71-73-6 O/U) and the Arizona Diamondbacks (76-75, 75-76 RL, 72-70-9 O/U) conclude a divisional series on Wednesday afternoon, and we have you covered with the prediction. The Giants are sending Justin Verlander to the mound. The Diamondbacks will reply with Brandon Pfaadt. The Diamondbacks lead the season series 6-5 entering Tuesday.
Can Verlander continue his dominance on Wednesday? Check out the Giants vs. Diamondbacks prediction. Nobody does it better when it comes to MLB Picks!
Verlander Continues Dominance for Giants
Justin Verlander is on the mound for the Giants. Verlander was sharp in his recent effort, keeping L.A. to only one run in seven innings, resulting in a no-decision in a game the Giants won. The future Hall of Famer has been dominant, conceding two or fewer runs in five of his past six outings and has delivered a 3.94 ERA and a 1.37 WHIP accompanied by a 3-10 record in 134.2 innings on the season. Verlander held Arizona to just two runs in six innings this season and has a 3.13 ERA and a 5-3 record in 54.2 career innings against the rivals.
The San Francisco Giants came out of nowhere to climb back into wildcard contention. They are only two games behind the Mets as we enter the final stretch. The Giants have cooled down recently. They dropped a home series against the Dodgers this past weekend due to a disastrous series on the mound, surrendering 24 runs. They stand at 37-38 on the road.
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Casey Schmitt has a strong .748 OPS this month. The 26-year-old third baseman homered in the series opener and has 37 RBIs and a .715 OPS on the year. Heliot Ramos has amassed just three RBIs this month. The young outfielder has bashed 17 home runs with 61 RBIs and a .729 OPS. Matt Chapman continues to rake, netting a robust 1.05 OPS in September. The veteran third baseman has bashed 21 home runs with 57 RBIs. Patrick Bailey has been key to the success this month. The 26-year-old catcher has recorded six RBIs in his past five games and now has 52 RBIs on the season.
San Francisco is averaging 4.35 runs on the year, ranking them 16th. The pitching staff has issued a strong 3.86 ERA, good for 10th.
Pfaadt Gets the Nod to End Series
The Diamondbacks are opting with Brandon Pfaadt in this one. Pfaadt was rocked in his previous effort, squandering five runs in 4.2 innings against Minnesota, and was able to escape with a no-decision in a game Arizona lost. The young righty has conceded six runs in 10.2 innings this month and is sporting a weak 5.31 ERA and a 1.40 WHIP, accompanied by a 13-8 record in 157.2 innings of work. Pfaadt has yielded eight runs in 10 innings against San Francisco this season and has issued a 5.11 ERA and an 0-4 record in 24.2 career innings.
The Arizona Diamondbacks appeared to be nearly eliminated from postseason contention again this season due to their shaky pitching. They have found some late magic and are enjoying their best stretch of the season. The Diamondbacks are now only 1,5 games out of the third wildcard spot. The Diamondbacks won a series in Minnesota this week, scoring 19 runs and conceding 15 runs, and posted a dominating win to begin this series. They are 39-34 at home.
Ketel Marte has been kept in check, issuing a .563 OPS this month. The star second baseman has posted 25 home runs with 65 RBIs. Geraldo Perdomo has been a tough out, registering a .1.1 OPS in September. The 25-year-old shortstop is having a breakout season, clubbing 19 big flies with 97 RBIs. Blaze Alexander has one RBI against the Giants this season. The young shortstop has 26 RBIs and a .740 OPS. Gabriel Moreno has missed a good portion of the season due to injury and has been outstanding upon his return. The 25-year-old catcher has six RBIs in his past six games and 37 RBIs in 72 games on the season.
Arizona is posting an average of 4.97 runs on the season, rating them fifth. The pitching is a weakness, posting a 4.45 ERA, placing them 22nd.
Giants vs. Diamondbacks Pick
Spread Pick for Giants vs. Diamondbacks
- San Francisco Giants -110 ( 5 units)
The San Francisco Giants are only two games out of a wildcard spot. Every game is a playoff game at this point in the season. The Arizona Diamondbacks are also in contention, just 1.5 games out of the wildcard entering Tuesday evening, but this pitching matchup favors the Giants. Also, Arizona is dealing with injuries as Gurriel Jr., who leads the team in RBIs, is out for the season.
Furthermore, Giants pitcher Justin Verlander has been as dominant as he’s been in years. The veteran has conceded a total of only nine runs in his past six starts. This includes just one run in his two outings this month. These are games the Giants must win, and no one has more experience in big games than Verlander. D-Backs pitcher Brandon Pfaadt is inconsistent and has posted a putrid 5.11 ERA in his career against S.F. He just surrendered five runs against Minnesota in his previous effort.
Over/Under Pick for Giants vs. Diamondbacks
- Over 9 (5 units)
I expect crooked numbers on the board. San Francisco just scored 19 runs in three games against the Diamondbacks last week and has averaged 5 runs against the rivals this season. Pfaadt can't be trusted in big games, and he has been shaky anyway, conceding 16 runs in his past 17.1 innings pitched.
In addition, Arizona is still generating runs despite missing key hitters. They have scored 32 runs in their past five games, including six runs in the first game of this series. Verlander is not as effective on the road, where he has posted a subpar 4.53 ERA on the season. The over is 5-2 in the past seven meetings between these rivals.
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