San Francisco Giants vs. Chicago Cubs Picks and Prediction for Saturday, June 6th, 2026

By: Adam Rauzino Published 06/06/2026, 05:15 AM ET
Giants vs. Cubs prediction.
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The San Francisco Giants (25-38, 25-38 ATS, 32-27-5 O/U) meet the Chicago Cubs (33-30, 26-37 ATS, 35-28 O/U) in the second of a three-game series on Saturday afternoon, and we have you covered with the prediction. The Giants are sending Landon Roupp to the mound. The Cubs will respond with Ben Brown. The Giants went 5-1 against the Cubs last season.

Can Ben Brown record his second straight win on Saturday? Continue reading to find out. Nobody does it better when it comes toΒ  MLB Picks!

Roupp Hit with Sixth Defeat of Season

Landon Roupp will get the nod in game two of the series. Roupp was pelted in his recent outing, conceding eight runs in four innings against the Brewers and was dealt the loss. The righty is having an inconsistent season. He did not register a win last month and has recorded a 4.22 ERA and a 1.31 WHIP and a 5-6 record in 64 innings pitched. He has 75 Ks. Roupp conceded four runs (two earned) in five innings in his only meeting against the Cubs.

The San Francisco Giants have been a disaster this season. The Giants have dropped four of their past five series due to the pitching. This includes a series loss against the Rockies. Next, the Giants rebounded by posting two wins in four road meetings against a potent Milwaukee team this week. The bats broke out with 18 runs while squandering 34 runs. The Giants are 13-22 on the road.

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Rafael Devers is having an inconsistent season. The 29-year-old star stumbled in April but drove in 19 runs in May. Devers has seven homers with 30 RBIs and a .700 OPS. Matt Chapman has five RBIs in his last eight games. The veteran third baseman has 23 RBIs and a .652 OPS on the season.

Casey Schmitt is enjoying a breakout season. The 27-year-old DH has clubbed 13 bombs with 35 RBIs and an .844 OPS. He recorded one RBI and a .333 OPS against the Cubs last season. Luis Arraez is enjoying a strong season at the plate. The 29-year-old does not have extra-base power but is a pure hitter. He has reported a .325 average with an .800 OPS. Willy Adames has knocked in six runs in his past five games. The 30-year-old shortstop has bashed nine homers with 25 RBIs and a .719 OPS.

San Francisco is averaging 3.96 runs per game, ranking them 26th. The Giants' pitching is also a weakness, posting a 4.58 ERA, placing them 22nd.

Brown Seeks Second Straight Win on Saturday

Ben Brown will be on the mound on Saturday afternoon. Brown came through with a gem last week, keeping the Cardinals to one run in seven innings and secured the win. The righty has been the Cubs' best pitcher. He has yielded just six runs in his past 29 innings and is sporting a dominant 1.92 ERA, a 0.93 WHIP to go with a 2-2 record in 51.2 innings pitched on the season. He has recorded 53 strikeouts. Brown conceded three runs in five innings in his only meeting against the Giants last season.

The Chicago Cubs were in first place in the division in April but have regressed since and now stand near last in a stacked division. They had lost 10 games in a row at one point last month. Chicago lost a series to the Cardinals last weekend and were dealt two defeats in three home games at the hands of the A’s this week. Chicago scored just 12 runs and conceded 13 runs. They are 0.5 games out of a wildcard spot. The squad is 19-13 at home.

Pete Crow-Armstrong is not playing to expectations. The 24-year-old has been a lot better in recent games and now has a mediocre .745 OPS on the season, which is just above the league average. Alex Bregman is having a disappointing season. He signed a huge contract in the offseason. The 32-year-old third baseman has amassed only three RBIs in his last 10 games. Bregman has netted 19 RBIs and a .696 OPS on the season.

Nico Horner is also slumping. The veteran second baseman yielded a .546 OPS last month and has 33 RBIs and a .695 OPS on the season. Dansby Swanson has two RBIs in his past 10 games. The veteran shortstop has 28 RBIs and a weak .618 OPS. Chicago needs their slugger Seiya Suzuki to break out. The 31-year-old outfielder issued a .551 OPS in May and only has 20 RBIs and a .730 OPS on the season. He drove in two runs against the Giants last season.

Chicago is posting an average of 4.69 runs on the season, marking them ninth. The Cubs have issued a 4.19 ERA, positioning them 18th in the big leagues.

Giants vs. Cubs Pick

Spread Pick for Cubs vs. Giants

  • Chicago Cubs -135 (5 units)

The San Francisco Giants have been a disaster and have no confidence. They have dropped seven of their last 10 games and have only won four of their past 11 road games. The Giants have won just 13 of 35 road games on the season. The Chicago Cubs have been shaky but are tough to beat at home, where they are sporting a 19-13 record.

Furthermore, Giants pitcher Landon Roupp was rocked in his recent outing, surrendering eight runs. The Giants do not win games when Roupp is on the mound, issuing an 0-6 record in his last six starts. Cubs pitcher Ben Brown has been their best starter, as seen in his dominant 1.92 ERA. He has conceded just two runs in his last 13 innings pitched and has conceded just one home run in his 51.2 innings pitched.

Over/Under Pick for Giants vs. Cubs

  • Under 8.5 (5 units)

I expect this one to go under. San Francisco has an abysmal offense that ranks near the bottom in many offensive categories, including runs scored. The Giants have scored three or fewer runs in six of their past ten games.

In addition, while I expect Chicago to score enough to get the win, Roupp has conceded two or fewer runs in two of his past three outings. Chicago has also been kept in check at the plate at home. They have netted three or fewer runs in seven of their past 10 home games. The under is a convincing 5-1 in Ben Brown's past six starts.

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