San Francisco Giants vs. Los Angeles Dodgers Picks and Prediction for Sunday, September 21, 2025
Use Code WWWC It’s the conclusion of a series on the diamond between a pair of NL West foes as the San Francisco Giants play the final game of a four-game set with the Los Angeles Dodgers Sunday afternoon and we have you covered with our Giants vs. Dodgers prediction. In the opening game of the series Thursday night, the Dodgers drew first blood with a 2-1 victory. Los Angeles followed that up with a 6-3 triumph on Friday night to clinch a playoff spot. Will the Dodgers take another step toward a NL West crown or can the Giants stay alive in the NL playoff chase? This article was published before the conclusion of the third game of the set at Dodger Stadium Saturday night. Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks! Read more about this Giants vs. Dodgers prediction!
San Francisco Sinking at Wrong Time
San Francisco lost for the sixth time in seven games as they were doubled up in the second game of this four-game set Friday night. The Giants entered Saturday 76-78 on the year and stood fourth in the NL West, 11 games behind the Dodgers for the top spot. They were four games behind the Mets for the final wild card spot in the National League. Against the Dodgers on Friday, San Francisco finished with eight hits, though Matt Chapman (run, RBI) was the only player to pick up a pair in the contest. Heliot Ramos (his 18th) homered in the loss for the Giants, who were two of 12 with runners in scoring position and left 10 men on base in the contest. Robbie Ray (11-8) took the loss as he allowed five runs on five hits with two walks and five strikeouts over 4.2 innings of work.
The Giants have yet to officially name a starter for this contest, but the hope is that Carson Whisenhunt will be activated from the IL to make his sixth start of the season here. He is 2-1 with a 5.01 ERA, a 1.457 WHIP, 12 walks and 16 strikeouts over 23.1 innings of work. Whisenhunt earned the win in his last start, which came on August 27 at home against the Cubs. He threw five innings, allowing three runs on five hits with three walks and three strikeouts in a 12-3 Giants win. In his last three starts, Whisenhunt is 1-1 with a 5.54 ERA, a 1.769 WHIP, eight walks, and nine strikeouts over 13 innings of work. Whisenhunt, in his sixth career major league start, pitches against the Dodgers for the first time here. As a result, this would be his first outing at Dodger Stadium. In the minors this season, Whisenhunt is 9-5 with a 4.47 ERA, a 1.366 WHIP, 33 walks and 93 strikeouts over 104.2 innings in 20 starts with Triple-A Sacramento of the International League.
Dodgers Looking to Secure NL West Crown
Los Angeles won their third straight game as they downed the Giants Friday night, clinching a playoff spot in the process. The Dodgers entered Saturday 87-67 and held a four-game lead on the Padres for the top spot in the NL West. Against San Francisco on Friday, Los Angeles finished with seven hits as Andy Pages (run, RBI) had three while Miguel Rojas (two runs, RBI) added a pair. Rojas (his seventh), Shohei Ohtani (his 52nd), and Mookie Betts (his 20th) went deep in the victory for the Dodgers in the win. Clayton Kershaw threw 4.1 innings, allowing two runs on four hits with four walks and six strikeouts, but didn’t factor in the decision. Edgardo Hernandez (2-1) earned the win as he threw 1.1 innings, allowing no runs on one hit with no walks and three strikeouts, in relief. Tanner Scott got one out, allowing no runs on one hit with no walks and one strikeout, for his 22nd save.
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Emmet Sheehan is on the bump for the Dodgers as he makes his 14th appearance, 11th start, in this contest. He is 6-3 with a 3.17 ERA, a 1.056 WHIP, 22 walks and 76 strikeouts over 65.1 innings of work this season. Sheehan didn’t factor in the decision in his last outing, which came in a home relief outing against the Phillies on Monday. He threw 5.2 innings, allowing one run on one hit with three walks and seven strikeouts, in a 6-5, 10-inning, Dodgers defeat. In his last three appearances, two starts, Sheehan is 1-1 with a 2.08 ERA, a 0.87 WHIP, six walks and 22 strikeouts over 17.1 innings of work. Sheehan makes his fourth career appearance, third start, against the Giants in this contest. He is 1-0 with a 1.20 ERA, a 0.733 WHIP, nine walks and 15 strikeouts over 15 innings of work in those outings. Sheehan is 4-1 with one save, a 2.57 ERA, a 0.914 WHIP, 25 walks and 78 strikeouts over 70 innings of work in 14 career appearances, 12 starts, at Dodger Stadium.
Giants vs. Dodgers Pick
Moneyline Pick for Giants vs. Dodgers
- Dodgers (4 units)
The Giants have cratered at the wrong time as far as the postseason goes, with six losses in their last seven games. San Francisco now has to leapfrog multiple teams in the final week of the regular season to try and make the playoff field. Facing the Dodgers isn’t going to help things, as Los Angeles has won four of the last five meetings entering Saturday. Having a shaky situation on the bump doesn’t help matters either. Los Angeles is trying to lock down the NL West title, and Sheehan has pitched well in his last several outings. With their prolific lineup, the advantage to the Dodgers in this contest.
Over/Under Pick for Giants vs. Dodgers
- Over (4 units)
San Francisco entered Saturday having stayed under the total in 75 of their 154 games, with seven pushes, on the season. The Giants are 17th in the majors with 4.32 runs per game, a number that climbs to 4.54 runs per game on the road. San Francisco has an average total of 8.55 runs per game and that number climbs to 8.72 runs per game on the road this season. Los Angeles entered Saturday having seen the under post a 75-71-8 mark in their 154 games on the season. The Dodgers are tied for 2nd in the majors as they average 5.10 runs a game, giving them an average total of 9.39 runs per contest. At home, Los Angeles averages 5.56 runs per game and has an average total of 9.93 runs per game this season. With the Giants having a question mark on the bump, look for the Dodgers’ bats to do some damage, pushing this over the total.
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