Seattle Mariners vs. St. Louis Cardinals Picks and Prediction for Saturday, April 25th, 2026
Use Code WWWC The Seattle Mariners (11-15, 8-18 ATS, 12-15 O/U) take on the St. Louis Cardinals (14-10, 13-11 ATS, 13-10-1 O/U ) in the second of a three-game series on Saturday evening, and we have the prediction. The Mariners are going with Bryan Woo. The Cardinals will answer with Matthew Liberatore. The Mariners won last year’s season series 3-0.
Can Bryan Woo post a second straight win on Saturday evening? Check out the Mariners vs. Cardinals prediction. Do you need a boost in your handicapping? Try our MLB Picks!
Seattle Sends Woo to the Mound
Bryan Woo will get the nod on Saturday. Woo was outstanding in his recent effort, keeping the Rangers to only two runs in seven innings, and was awarded his first win of the season. The young righty has been the Mariners' best pitcher this season. Woo has yielded two or fewer runs in all but one outing and has delivered a 2.25 ERA and a 0.88 WHIP, accompanied by a 1-2 record in 32 innings pitched. He has earned 26 strikeouts. Woo has made just one start against the Cardinals, holding them to two runs in six innings, and secured the win.
The Seattle Mariners had a sluggish opening month to the season and have not quite been able to rebound with any consistent series wins. They had lost three straight series at one point. The Mariners won two of three against the Rangers last weekend and had a shaky series against the Athletics, dropping two of three games. Seattle scored 11 runs and kept them to 15 runs. The Mariners are 1-8 on the road.
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Randy Arozarena has been a huge threat at the dish, amassing 10 RBIs along with a strong .805 OPS. The veteran slugger was a tough out against the Cardinals last season, posting a .976 OPS. Josh Naylor is one of many slumping hitters on this squad. The veteran first baseman signed a big contract in the offseason but has collected 10 RBIs and a disastrous .550 OPS.
Cal Raleigh is starting to find his power swing this season. The star catcher hit 60 bombs last season and has now bashed five big flies so far. Raleigh has recorded a weak .667 OPS. Luke Raley has been a surprise, bringing in 11 runs, while Brandon Donovan is also in a groove, posting a .960 OPS.
Seattle is scoring an average of 3.88 runs per game, ranking them 25th. The Mariners' pitching is a strength, posting a 3.42 ERA, placing them sixth in the big leagues.
Liberatore Seeks First Win of Season
The Cards will have Matthew Liberatore on the rubber. Liberatore came through with a gem in his recent outing, conceding just one run in six innings against the Astros, but did not get any help from the offense and finished with the no-decision in a game the Cards won. The young southpaw has kept the opponent to one run in three of his five outings and is sporting a 3.67 ERA and a 1.41 WHIP, accompanied by a 0-1 record in 27 innings pitched. He has 16 strikeouts. He squandered seven runs in 3.2 innings in his only career meeting against the Mariners.
The St. Louis Cardinals are a young squad with potential. They have displayed that potential in the first month of the season. The squad is second in the NL Central behind only the Reds. The Cardinals have two of their last three series. They posted a huge road sweep of the Astros last weekend and lost two of three road encounters against the Marlins this week. The offense netted only nine runs and kept the Marlins to 12 runs. They stand at 7-5 at home.
Jordan Walker is developing into a mammoth threat at the dish. The 23-year-old was a top prospect and is living up to the hype, netting 16 RBIs accompanied by a dazzling .960 OPS. He went 0 for 3 against the Mariners last season. Alec Burleson has also been key at the plate in the first month. The 27-year-old first baseman has driven in 17 runs to go with an .800 OPS.
Mason Winn is another talented young player. The 24-year-old shortstop had a bit of a slow opening few weeks but has found his swing, accumulating nine RBIs in his past six games. Winn has nine RBIs on the year. J.J. Weatherhold is also clicking, producing 11 RBIs and a .708 OPS. Vitor Scott II has been quiet, posting four RBIs.
St. Louis has been solid at the plate, posting an average of 4.67 runs per game, marking them 12th. They have a 4.77 ERA, placing them 25th in the big leagues.
Mariners vs. Cardinals Pick
Spread Pick for Mariners vs. Cardinals
- Seattle Mariners -150 (5 units)
The Seattle Mariners have been inconsistent, but are the better team in this matchup. They have won three of their past five games entering Friday. The Cardinals are an exciting team, but they are young. They are playing above their heads and are due to regress. They dropped two of three meetings against the Marlins this week.
Furthermore, Mariners pitcher Bryan Woo has been the Mariners ace. The righty has been stingy, keeping his opponents to two or fewer runs in four of his five starts. He has been up against potent offensive teams in the Rangers and Padres. Also, Cards' pitcher Matthew Liberatore has been shaky, squandering four or more runs in two of his past three outings. This includes four runs against Cleveland in his most recent home outing. Go with the Mariners in this one.
Over/Under Pick for Mariners vs. Cardinals
- Over 8 (5 units)
I expect plenty of scoring. Seattle is heating up at the dish after slumping in the first three weeks. They have scored 23 runs in their past five games. The Cards have given up 22 runs in their past five games. Liberatore is not pitching deep into games, going five or fewer innings in three of his five starts. This is key considering the bullpen has been a weakness, posting a 5.17 ERA.
In addition. St. Louis is also enjoying success with the bats. They have plated at least five runs in five of their past seven games, including 23 runs in their series against the Astros.
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