St. Louis Cardinals at Chicago Cubs, Picks and Prediction, Friday September 26, 2025
Use Code WWWC The Chicago Cubs close out their regular season at home with a three-game rivalry set against the St. Louis Cardinals, starting Friday at Wrigley Field. These long-time NL Central foes have split their 10 meetings this season, and while the Cardinals are officially out of postseason contention they could finish with a .500 record with a sweep.
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Cardinals eliminated
The Cardinals have been eliminated from postseason contention, but there’s still pride, and a chance to finish at .500 on the line this weekend. At 78-81, a series sweep in Chicago would get them back to even for the season, which would be a small victory for a team that’s battled through inconsistency all year.
St. Louis has quietly shown fight down the stretch, winning three of its last four games before falling 4-3 to the Giants on Wednesday. After Thursday’s off day, they should be well-rested heading into Wrigley. Away from home, the Cardinals are just 34-44, but they’ve shown signs of improved offensive production lately, scoring at least five runs in three of their last four contests.
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Veteran right-hander Miles Mikolas takes the mound, and he’s been solid of late. Over his last five starts, he’s 3-2 with a 2.77 ERA, giving St. Louis a chance every time out. Mikolas has plenty of history against the Cubs, going 6-7 with a 3.59 ERA in 24 career appearances.
Cubs stumbling into postseason
The Cubs enter the series sitting atop the Wild Card standings, but they have dropped six of its last seven games, including an 8-5 setback to the Mets on Saturday, which exposed the same bullpen issues that have plagued them all month. On the bright side, the postseason has been clinched and the Cubs are 47-31 at Wrigley Field this year.
Colin Rea will get the ball Friday night, and while his overall numbers (10-7, 4.10 ERA) have been respectable, his recent form has been shaky. Over his last five outings, Rea has posted a 5.06 ERA, struggling with command and failing to pitch deep into games. His history against the Cardinals is mixed—3-3 with a 3.59 ERA in 11 appearances.
St. Louis Cardinals vs Chicago Cubs Predictions
Cardinals vs Cubs Money Line Pick
- Cardinals +1.5 (-135) 4 units
Given the Cubs’ recent struggles, it’s tough to justify laying heavy juice in this spot. Chicago hasn’t locked up the top Wild Card just yet, but with a two-game cushion, this isn’t a “do-or-die” scenario. Meanwhile, St. Louis comes in loose, motivated by the chance to finish .500 and spoil their rival’s party.
Mikolas has been in better form than Rea over the last month, and the Cardinals’ offense has been showing signs of life. With Chicago’s bullpen issues still unresolved, St. Louis has a great chance to keep this one close, if not win outright. In a rivalry game with momentum leaning toward the visitors, the safer play is to grab the run line with the Cardinals.
Cubs vs Cardinals Total Picks
- Over 9.0 (4 Units)
Both teams have been involved in high-scoring contests lately. The Cubs have combined for 13 or more runs in each of their last three games, while the Cardinals have scored at least five runs in three of their last four. Rea has been hittable in September, and although Mikolas has been steadier, the Cubs’ offense is capable of breaking out at any time in their hitter-friendly home park. With bullpens on both sides showing cracks, the Over is the play.
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