St. Louis Cardinals vs Chicago Cubs Picks and Prediction for Saturday July 4 2026

By: Dylan Hellebrand Published 07/04/2026, 05:40 AM ET
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On Saturday, the St. Louis Cardinals (45–39) head to Chicago to take on the Cubs (49–38) at iconic Wrigley Field. The Cardinals will be trying to close the gap and pull within striking distance of the Cubs as they battle for second place in the division. Get involved in the action with our free MLB picks.

St. Louis vs. Chicago Game Information

  • July 4, 2026
  • 8:08 PM EST
  • Wrigley Field
  • FOX/MLB.TV/Fubo

Chicago Form & Recent Results

Chicago heads into Saturday’s game feeling as confident as a team can be, riding a five-game winning streak into Friday night’s series opener against the St. Louis Cardinals. That hot stretch has featured some statement wins, including a full home sweep of the Padres and then taking two games in Milwaukee against the Brewers, which is never an easy place to win. The Cubs’ offense has been the clear driving force behind the run, consistently putting pressure on opposing pitchers and turning close games into comfortable ones. With the NL Central race for second place tight, this series carries extra weight, and Chicago will want to keep that momentum rolling in what shapes up as a key matchup.

The most eye-opening moment of the streak came Wednesday at Wrigley Field, when the Cubs demolished San Diego 23–3 in a game that looked more like a football score than a baseball final. Shortstop Dansby Swanson was the star of the show, going 3-for-5 with three home runs, four runs scored, and an incredible eight RBIs. On the mound, starter Colin Rea did his job by keeping things steady over five innings, giving up six hits and two earned runs while walking three and striking out five. The numbers from that game were almost unreal: 17 total hits, eight home runs, and 43 total bases as Chicago’s lineup overwhelmed the Padres from start to finish. On the season, Pete Crow-Armstrong has emerged as their main power threat with 19 home runs, followed closely by Ian Happ with 17. Swanson has been their most productive run driver with 57 RBIs, while Crow-Armstrong also tops the team in batting average at .287. Overall, during this five-game surge, the Cubs have been scoring 9.4 runs per game, and they’ll try to keep their bats blazing as they look to hold off the Cardinals in the middle game of the series on Saturday.

St. Louis Form & Recent Results

St. Louis comes into this matchup feeling a little more confident, riding a one-game winning streak and having taken three of their last five games heading into Friday. Two of those recent wins came in Atlanta against the Braves and the other was a home victory over the Marlins. The Cardinals’ most recent statement came Thursday on the road, when they powered past the Braves 11–5. Right fielder Jordan Walker was right in the middle of everything, going 2-for-4 with a home run, scoring twice, and driving in four runs. The offense as a whole was locked in as well, piling up 15 hits, launching three homers, and collecting 25 total bases, one of those nights where it felt like someone was on base almost every inning.

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Walker has been the engine for St. Louis throughout the season, leading the team in home runs with 19, RBI with 63, and even batting average at .291. He’s been their most consistent all-around hitter, and when he’s producing like he did in Atlanta, the lineup looks much deeper. Behind him, first baseman Alec Burleson has also provided plenty of pop, sitting second on the team with 14 home runs. Even so, the Cardinals haven’t exactly been lighting up the scoreboard lately, as they’re averaging about four runs per game in their last five. That’s why Saturday night at Wrigley feels like a real test, as St. Louis will need timely hitting again, but just as importantly, they’ll be trying to slow down a Cubs offense that’s been on a serious tear.

Key Stats

  • St. Louis’ Jordan Walker this season: 19 HRs, 63 RBI, .291 AVG
  • Chicago’s Pete Crow-Armstrong this season: 19 HRs, 49 RBI, .287 AVG

Betting Odds & Market Overview:

  • CHC -163 / STL +135; O/U 8.5

St. Louis vs. Chicago Picks and Prediction

The Cubs are still riding the momentum from their wild 23–3 blowout of the Padres a few days ago, and they’ll try to keep that bats-on-fire stretch going in this matchup. The Cardinals, meanwhile, will be focused on slowing Chicago down and keeping the game from turning into another offensive avalanche. St. Louis is set to hand the ball to right-hander Kyle Leahy, who’s been fairly steady this season with a 6–4 record and a 4.09 ERA. The Cubs will counter with Shota Imanaga, who comes in at 5–6 with a 4.30 ERA and will be looking to lock in early and give Chicago a chance to stay in control. Final Score Prediction, Chicago Cubs win 2-1.

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