St. Louis Cardinals vs. Chicago Cubs Picks and Prediction for Sunday, September 28th, 2025
Use Code WWWC The St. Louis Cardinals (78-82, 79-82 RL, 80-72-8 O/U) and the Chicago Cubs (90-70, 75-86 RL, 73-74-12 O/U) conclude the regular season on Sunday afternoon, and we have you covered with the prediction. The Cardinals are opting with Kyle Leahy. The Cubs are expected to answer with Javier Assad. The Cubs lead the season series 6-5.
Can the Cubs conclude the regular season with a home win on Sunday before hosting the Padres in the wildcard series? Check out the Cardinals vs. Cubs prediction. Nobody does it better when it comes to MLB Picks!
Cards Wrap Up Disappointing Season
Kyle Leahy is expected to get the nod to conclude the season. Leahy has been used out of the bullpen the entire season. The rookie posted one scoreless inning against the Giants in his recent outing last week. Leahy has been steady, posting a 3.18 ERA and a 1.26 WHIP accompanied by a 4-2 record in 85 innings pitched on the season. He has conceded two runs in 3.2 innings against the Cubs this season.
The St. Louis Cardinals had a disappointing season, but could be contending for a postseason spot next year. They are going to finish below the .500 mark. They only won a few series this month, including two wins in three clashes against the Giants prior to this series. They conceded 17 runs. The Cards are 34-35 on the road.
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Brendan Donovan has issued a sharp 1.05 OPS this month. The 28-year-old is having a solid year, bashing 10 home runs with 50 RBIs and a .775 OPS. Ivan Herrera is having a breakout season. The catcher has posted 16 RBIs this month and 19 homers with 66 RBIs on the year. William Contreras is on the IL and will not play. Nolan Arenado was not able to find a groove this season. The veteran third baseman has posted a .658 OPS this month and has 11 homers with 51 RBIs and a .655 OPS on the year, marking the worst season of his career. He has zero RBIs against the Cubs this season.
St. Louis is averaging 4.29 runs per game, ranking them 19th. The pitching staff has a 4.26 ERA, placing them 19th.
Cubs End Season in Wildcard Spot
The Cubs have yet to name a pitcher. They could be going with a bullpen game or Javier Assad on Sunday. Assad last pitched on the 20th and squandered two runs in four innings against Cincinnati, ending in a no-decision in a game the Cubs lost. The veteran has conceded nine runs in his past 16.2 innings of work and is sporting a 4.26 ERA and a 1.29 WHIP, accompanied by a 3-1 record in 31.2 innings pitched on the season. He has netted a sharp 3.58 ERA and an 0-2 record in 27.2 career innings against the Cardinals.
The Chicago Cubs are back in the postseason. They have secured the 1st wildcard spot and are going to be playing the Padres in the wildcard series this week. The Cubs have been shaky recently, dropping five of their past six games. They dropped a series against the Mets this week, conceding 20 runs, and rebounded with wins in the first two games of this series. The Cubs are 50-31 at home.
Pete Crow-Armstrong has struggled the past few months. The 23-year-old has posted a weak .525 OPS in September but has 30 big flies with 93 RBIs on the year. Kyle Tucker has been activated from the IL just in time for the postseason. The veteran slugger has only played a few games this month. Tucker has 22 homers with 73 RBIs. Nico Hoerner has a robust .991 OPS against the Cards this season. The veteran second baseman is having an outstanding season, hitting .300 with 61 RBIs and a .747 OPS. Seiya Suzuki has six RBIs in his last five games. The veteran slugger has 30 home runs with 101 RBIs.
Chicago is scoring an average of 4.90 runs on this year, good for fifth. The pitching staff is a strength, reporting a stingy 3.80 ERA, placing them ninth.
Cardinals vs. Cubs Pick
Spread Pick for Cardinals vs. Cubs
- Chicago Cubs -1.5 (5 units)
The St. Louis Cardinals are having trouble winning games down the stretch. They have only won two series in September. The Chicago Cubs want to enter the postseason with confidence. They lead the season series. The Cubs beat the Cards 12-1 in the series opener and posted a 7-3 win on Saturday.
Furthermore, St. Louis struggles to win on the road, where they are 11 games below .500. The Cubs are hard to beat at home, where they stand 17 games above the .500 mark. Cards pitcher Kyle Leahy has been used as a reliever. He has been strong but won’t pitch more than a few innings. He has conceded two runs on five hits in 3.2 innings against the Cubs this season. Cubs pitcher Javier Assad is expected to pitch bulk innings. Assad thrived against the rivals, posting a strong 3.58 ERA in his career against St. Louis.
Over/Under Pick for Cardinals vs. Cubs
- Over (5 units)
I expect a barrage of scoring. St. Louis has been decent at the dish, scoring 22 runs in its past five road games. Assad usually doesn't pitch more than five innings. He has been shaky, conceding nine runs in his past 16 innings of work.
In addition, Chicago has piled on the runs against the Cards this season, averaging 6.5 runs in the 12 meetings, including 19 runs in this series. The Cards' pitching has been exposed, squandering 36 runs in their past five road games. Also, the Cubs open their wildcard series on Tuesday, and they won't want to wear out their top relievers. The over is a convincing 5-0-1 in the Cubs' past six home games.
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