St Louis Cardinals vs Chicago Cubs Prediction and Picks - September 27, 2025
Use Code WWWC National League Central MLB action on Saturday afternoon, we have a St Louis Cardinals vs Chicago Cubs Prediction ready to go. The Cardinals will not be a part of the postseason party, and they come in with a 78-81 record. The Cubs have gone 89-69 on the year and they will be in the postseason as the top wildcard team. Read on to see our Cardinals vs Cubs prediction.
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Cards Are Just Playing Out The String
St. Louis fell behind early and never recovered in the 12–1 loss. Miles Mikolas yielded four runs in five innings, and the bullpen was tagged for eight more as the game unraveled in the seventh. Offensively, the Cardinals were limited to five hits; Jordan Walker drove in the lone run with a seventh-inning single, and Nolan Gorman contributed a double as St. Louis finished 2-for-6 with runners in scoring position.
The defeat dropped the Cardinals to 78–82 and underscored recent issues preventing sustained momentum. Extra-base power has shown up in flashes, but short outings and high-leverage misses on the mound have put the lineup in chase mode too often. With just a handful of games left, cleaner innings from the staff and length from the starter are paramount to keep the bullpen from heavy mid-game exposure.
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Michael McGreevy is slated to get the ball Saturday, bringing an 8–3 record and 4.35 ERA into the matchup. His path is straightforward at Wrigley: fill the zone, limit traffic, and keep the ball in the park against a Cubs lineup that homered four times on Friday. Offensively, St. Louis will look for quality at-bats from the middle—Gorman, Walker, and Nolan Arenado—to create early scoring chances and avoid playing from behind.
Cubs Look To Head To The Postseason With Momentum
Chicago hammered St. Louis 12–1 on Friday, piling up 12 hits and four home runs. Nico Hoerner started the scoring with a solo shot in the first, Pete Crow-Armstrong added a two-run homer in the fourth, Michael Busch went deep in the fifth, and Seiya Suzuki broke it open with a grand slam in the seventh. Colin Rea set the tone with 5⅔ scoreless innings, allowing two hits with seven strikeouts before the bullpen covered the final frames.
The win pushed Chicago to 90–70 and tightened their grip on postseason positioning. Crow-Armstrong reached a rare 30-30-30 season (30 homers, 30 doubles, 30 steals), and Suzuki’s slam marked his 30th homer while he crossed the 100-RBI mark. Chicago kept traffic on the bases with timely extra-base hits and went 6-for-10 with runners in scoring position, showcasing the balanced production that’s fueled their late-September surge.
For Saturday afternoon, the Cubs list Jameson Taillon as the probable starter. He enters at 10–7 with a 3.78 ERA, leaning on strike-throwing and soft contact to work into the middle innings. With day game conditions at Wrigley and the lineup producing up and down the order, Chicago will look to carry over Friday’s approach—early damage and pressure in leverage spots—to support Taillon.
St Louis Cardinals vs Chicago Cubs Pick
Cardinals vs Cubs Moneyline Pick
- Chicago -167 (5 Units)
The Cubs enter Saturday’s matchup with confidence after dismantling the Cardinals 12-1 on Friday, showing both power and balance at the plate. Seiya Suzuki’s grand slam and Michael Busch’s homer highlighted a lineup that continues to produce in key moments, and Nico Hoerner along with Pete Crow-Armstrong set the tone early with long balls. With Jameson Taillon on the mound carrying a 10-7 record and 3.78 ERA, Chicago should have the advantage against a St. Louis offense that has struggled to string together consistent rallies late in the season.
On the other side, St. Louis turns to Michael McGreevy, who has been serviceable but faces a difficult assignment against a Cubs lineup that punished mistakes all afternoon in the opener. Chicago’s depth is shining at the right time, with multiple players capable of carrying the offense on any given day. Combine that with a steady starting pitcher and a bullpen that has been strong down the stretch, and the Cubs are in a good position to secure another win at Wrigley and maintain momentum in the postseason race.
Cardinals vs Cubs Over/Under Pick
- Over 9 (4 Units)
With the total set at 9, the Over is in play given how hot Chicago’s bats are and the questions surrounding St. Louis’ pitching staff. The Cubs erupted for 12 runs on Friday with four home runs, and they’ve been consistently producing extra-base power in recent games. Michael McGreevy has been shaky against lineups with pop, and Chicago has multiple hitters swinging well heading into Saturday. Even if Jameson Taillon provides a quality start, the Cardinals have enough talent in the middle of their order to contribute, making a high-scoring game a strong possibility.
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