St. Louis Cardinals vs Cincinnati Reds Picks and Prediction for Sunday, May 24, 2026

By: Liam Keating Published 05/24/2026, 04:50 AM ET
Cardinals vs Reds prediction
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It's a clash in the National League Central division on Saturday, May 24. Read our St. Louis Cardinals vs Cincinnati Reds prediction along with our otherย Free MLB Picks on the night.

The Cardinals are in second in the division as they have the best road record in the National League. The Reds are near the bottom of the division, but they are still playing .500 ball. The Cardinals are set to start Matthew Liberatore, while Brady Singer gets the nod for the Reds. These two teams will meet with first pitch set for 1:40 P.M. EST.

Cardinals playing well on the road this year

The Cardinals are sitting in second place in the National League Central. Before Saturday's game, the Cardinals are just two games back of the Brewers for first place in the division. They own the best record when playing on the road in the National League, too.

Matthew Liberatore gets the start for the Cardinals. The left-handed pitcher is 2-2 with a 4.70 ERA in 10 starts this season. He last threw 4.2 innings against the Pirates on May 19. He allowed four earned runs and seven hits, while striking out nine batters in a 9-6 win. The Cardinals are 7-3 when Liberatore has started this season. He has a 4.09 ERA when pitching on the road. He also owns a 3.54 ERA during day games.

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The Cardinals are hitting .242 this season, which ranks 13th in the league. They rank 11th in runs scored and 13th in total hits. St. Louis ranks 12th in home runs hit and ninth in strike outs. The Cardinals are hitting .240 during road games and .247 during the month of May. They also own a .252 batting average against divisional opponents.

Reds battling in the basement of the division

Cincinnati is in last place in the National League Central division. The Reds are hovering around .500 so far this season. They have been about the same at home as they are on the road, too. Cincinnati has lost six of their last 10 games before Saturday's game.

On Sunday, Brady Singer starts for the Reds in this game. The right-handed pitcher is 2-4 with a 6.26 ERA in 10 starts. He threw four innings and allowed five runs and seven hits in the team's 10-3 loss to Cleveland on May 17. The Reds have lost four straight games that Singer has started. He has a 4.26 ERA during home games and with a 6.16 ERA when pitching during the day.

The Reds are hitting .227 this season, which ranks fourth-worst in the league. They rank 17th in runs scored while they have the fourth fewest hits in the sport. Cincinnati has hit the fifth-most homers, but they have struck out the eighth most times. Cincinnati is hitting .219 at home and .236 this month. But, they do own a .194 batting average in the NL Central.

St. Louis Cardinals vs Cincinnati Reds Picks

Cardinals vs Reds Spread Pick

  • Take the Cardinals to cover (5 units)

The Cardinals have been playing some great baseball especially on the road. They will take this win with ease, as starting pitcher Matthew Liberatore will dominate. The left-handed pitcher has a 3.54 ERA during day games. The Cardinals are also 7-3 when he has started this season. The Reds have struggled when Brady Singer has started, too. Singer has a 6.16 ERA during day games and a 4.26 ERA at home. Expect St. Louisโ€™ offense to find a rhythm early and attack singer, while Liberatore is able to shred Cincinnatiโ€™s lineup that has the fourth-worst batting average in the league.

Take the Cardinals to cover.

Cardinals vs Reds Over/Under Pick

  • Take the under (5 units)ย 

The Reds have the fourth fewest hits and their offense is only supplemented by the home run hitting power. If the long ball isn't going, the Reds struggle to score. The Cardinals pitcher will slow down the lineup, while St. Louis only ranks 13th in hits and runs scored. This should be a low scoring affair in Ohio.

Take the under on Sunday.ย 

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