St. Louis Cardinals vs. Cincinnati Reds, Picks and Prediction, Saturday, May 23, 2026
Use Code WWWC St. Louis (28-21) will be trying to make up some ground in the NL Central when they visit Great American Ball Park on Saturday night to face Cincinnati (26-24) in the second game of their three-game series at 7:15 PM. ET. Read on to find out which team picks up the win in this Cardinals vs. Reds prediction. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Andre Pallante, 4-4, 4.04 ERA, will get the start for the Cardinals. The Reds will counter with Brady Singer, 2-4, 6.26 ERA.
Cincinnati and St. Louis split their last 10 meetings.
**This preview was written before Friday’s game was played.**
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Cardinals Trying To Bounce Back From Series Loss
The Cardinals followed up their series wins over the Athletics and Royals with a series loss to the Pirates. They are third in the NL Central, two games behind the division-leading Brewers, and will try to reduce the distance with a series win over the Reds.
St. Louis averages 4.47 runs per game, which is 12th in the league. Their .240 batting average is 16th in the league. Their .320 on base percentage is 15th, while their .389 slugging percentage is 14th.
Jordan Walker has been the most consistent batter for the Cardinals. He leads the team with a .295 batting average, 13 home runs, and 35 RBI.
St. Louis is giving up 4.57 runs per game, which is 19th in the league. Opponents have a .257 batting average against the Cardinals, which is 26th in the league. Their 4.24 ERA is 19th, while their 1.38 WHIP is 23rd.
In his last start, Pallante gave up eight hits and two runs in 6.2 innings, leading to a 2-0 loss to the Royals. He is 6-4 with a 2.49 ERA in 19 games against the Reds.
Reds Going For Second Consecutive Series Win
The Reds bounced back from their series loss to the Guardians with a series win over the Phillies. They are at the bottom of the NL Central standings, 2.5 games behind the Cardinals, and will try to move up the standings with a win on Saturday.
Cincinnati averages 4.42 runs per game, which is 14th in the league. Their .229 batting average is 27th in the league. Their .312 on base percentage is 22nd, while their .394 slugging percentage is 24th.
Elly De La Cruz leads the Reds with a .290 batting average, while Sal Stewart leads the team with 12 home runs, and 34 RBI.
Cincinnati is giving up 4.98 runs per game, which is 25th in the league. Opponents have a .248 batting average against the Reds, which is 22nd in the league. Their 4.71 ERA is 25th, while their 1.46 WHIP is 27th.
In his last start, Singer gave up seven hits and five runs in four innings, leading to a 10-3 loss to Cleveland. He is 2-3 with a 5.04 ERA in five games against the Cardinals.
Cardinals vs. Reds Picks
Money Line Pick for Cardinals vs. Reds
- St. Louis Cardinals ML (4 Units)
The Cardinals have the edge in this game because they’re playing well offensively, and scored at least five runs in two of their last three road games. They’ve done well against right-handers, and they’re going up against Singer, who has struggled on the mound this season. He gave up 12 runs in his last three starts, and with Cincinnati’s bullpen also struggling, expect them to have a hard time slowing down the Cardinals.
Cincinnati will have a hard time keeping up offensively because they’ve struggled against right-handers, and Pallante has done a good job on the mound for the Cardinals, giving up 11 runs in his last four starts. He gave up four runs in his last two road starts, and with St. Louis’ bullpen playing better in recent road games, expect them to keep Cincinnati’s offense in check. Take St. Louis on the money line.
Over/Under Pick for Cardinals vs. Reds
- Over (4 Units)
The Cardinals average 4.47 runs per game. They’re batting .238 against right-handers, and they’re facing a starter who gave up at least four runs in three of his last four starts. The Reds average 4.42 runs per game. They’re batting .231 against right-handers, and they’re facing a starter who gave up 10 runs in his last three starts. Expect these teams to score enough runs to push the score over the total.
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