St. Louis Cardinals vs Detroit Tigers Picks and Predictions for Sunday, April 5, 2026

By: Cameron Ross Published 04/05/2026, 06:40 AM ET
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The Saint Louis Cardinals stay on the road Sunday night with a 7:20 PM game inside Comerica Park in Detroit, MI, against the Detroit Tigers, and we have you ready to roll with our St. Louis vs Detroit prediction. Saint Louis comes into this matchup with four wins and four losses on the year. The Detroit Tigers stay home on Sunday with four wins and four losses as well. Saint Louis has dropped three of the last five, including two in a row, following a 5-run road loss to Detroit last time out. The Tigers enter this matchup on a 2 game-winning streak after winning the first two games of this series. Read more about thisย St. Louis vs Detroitprediction! Struggling with handicapping? Try ourย MLB Predictions!

Cardinals look to end losing streak

The Saint Louis offense has been mediocre this season, with a .20 batting average. The Cardinals have scored 29 runs on 52 hits this season. Saint Louis has a .278 OBP and a .347 team slugging percentage. The Saint Louis pitching has struggled as well, with a 4.29 team ERA. Dustin May got the start for Saint Louis in their last outing, giving up seven runs on seven hits across 3.1 innings of work, resulting in the loss. The Saint Louis bullpen gave up four runs on five hits over the final 4.2 innings of work. Jordan Walker led the way for the Saint Louis offense in their last outing with three hits and four at-bats to drive in five total runs.

Victor Scott II leads the Saint Louis offense this season with a .308 batting average. Alec Burleson has a .276 batting average to go along with the team-leading eight hits. Nolan Gorman has a .192 batting average this season, but is one of two players on the roster with two home runs this season. Jordan Walker has a .296 batting average to go along with two home runs and a team-leading eight RBI this year.

Key Injury Report for St. Louis:

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  • Masyn Winn (Day-To-Day)
  • Hunter Dobbins (15-Day IL)
  • Matt Pushard (15-Day IL)
  • Lars Nootbaar (60-Day IL)
  • Ixan Henderson (60-Day IL)

Tigers go for 3 in a row

Offensively, Detroit has been below average this season, with a .228 batting average. The Tigers have scored 28 runs on 53 hits this season. Detroit has a .306 OBP and a .323 team slugging percentage. Detroit's pitching has been the team's biggest strength, with a 3.20 team ERA. Jack Flaherty got the start for Detroit in their last outing, giving up five runs on three hits across 4 innings of work, resulting in a new decision. The Detroit bullpen did the work, however, giving up one run on three hits over the final five innings to secure the victory. ย Matt Vierling, Kerry Carpenter, and Zach McKinstry led the way for the Detroit offense in their last outing, driving in three runs apiece.

Colt Keith leads the Detroit offense this season with a .417 batting average. Riley Green has a .226 batting average, and Kevin McGonigle has a .333 batting average. Dillon Dingler has a .273 batting average, along with the team leading two home runs and seven RBI's this season.

Key Injury Report for Detroit:

  • Sawyer Gipson-Long (15-Day IL)
  • Scott Effross (7-Day IL)
  • Troy Watson 7-Day IL)
  • Dugan Darnell (7-Day IL)
  • Tyler Owens (7-Day IL)

St. Louis vs Detroit Pick

St. Louis vs Detroit Spread Pick

Both teams have been mediocre to start the year, but Detroit will have the edge in this game. Look for the Tigers to use their strengths on both sides of the dish to do the work. ย Detroit will have the edge, start to finish, on Sunday against a struggling St. Louis team. Take the Tigers on Sunday to get a needed win against the St. Louis Cardinals at home.

St. Louis vs Detroit Over/Under Pick

Neither team has a potent offense, but neither team sends an elite pitcher to the mound. Look for offense to wake up in this game as the product runs in bunches. ย Both teams will score consistently on Sunday, leading to a high total. Take the Over Sunday as the Detroit Tigers get the home win.

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