St. Louis Cardinals vs Milwaukee Brewers Picks and Prediction for Sunday September 27 2026

The St. Louis Cardinals (77-83) face off against the Milwaukee Brewers (101-59) at American Family Field in Milwaukee, Wisconsin on Sunday. Get involved in the action with our free MLB picks.

St. Louis vs. Milwaukee Game Information

• September 27, 2026
• 3:10 PM EST
• American Family Field
• Brewers.TV/Cardinals.TV/MLB.TV/Fubo

Milwaukee Form & Recent Results

Milwaukee heads into this matchup carrying a three-game winning streak and victories in four of its last five games before Saturday’s contest. Their recent performances have included a strong mix of wins against quality opponents, with one victory coming at home against the Cardinals on Friday, two more coming on the road against the Phillies in Philadelphia, and another impressive win taking place in Baltimore against the Orioles. The Brewers looked especially sharp in their 8-4 win over St. Louis on Friday, putting together a well-rounded performance on both sides of the ball. Second baseman Brice Turang had a standout night at the plate, going 3-for-5 with two doubles, a single, two runs scored, and three runs driven in. On the mound, starting pitcher Robert Gasser gave Milwaukee exactly the kind of outing it needed, working six strong innings while allowing just one hit and one earned run. He also walked only one batter and struck out nine, helping set the tone for the Brewers’ pitching staff. As a team, Milwaukee finished that game with twelve hits and fifteen total bases, while the pitching staff combined for twelve strikeouts, gave up only six hits, and issued just one walk.

The Brewers have been getting steady production from several key players throughout the season, which is a major reason they enter the 2026 playoffs as the number one seed in the National League. First baseman Jake Bauers has provided plenty of power in the lineup and leads Milwaukee with twenty-six home runs on the year. Not far behind him is left fielder Jackson Chourio, who has put together an excellent season of his own with twenty-five home runs, making him the team’s second-leading home run hitter. Chourio has also been one of Milwaukee’s most consistent hitters overall, leading the club with a .286 batting average. Meanwhile, Brice Turang has been a major run producer for the Brewers, leading the team with ninety-seven RBI so far this season. Milwaukee’s offense has also been solid down the stretch, averaging 4.8 runs per game over its last five contests. With their lineup producing, their pitching staff performing well, and momentum clearly on their side, the Brewers come into this matchup looking like a confident and dangerous team.

St. Louis Form & Recent Results

The St. Louis Cardinals are heading into their final match of the season looking to snap out of a recent funk. They are currently mired in a tough two-game losing streak. The team has dropped three of their last five matchups heading into Saturday's action. This rough patch includes dropping two frustrating games against the Pirates in Pittsburgh. It also features a tough 8-4 defeat at the hands of the Brewers in Milwaukee on Friday night. Despite the loss, there were still some bright spots for the Redbirds' offense, particularly from Alec Burleson. Coming off the bench as a pinch hitter, Burleson made his limited opportunities count. He went 1-for-2 at the plate, launching a crucial home run, scoring a run, and driving in two RBIs. As a collective unit, the St. Louis lineup showed off some serious muscle by launching three home runs and accumulating fifteen total bases. Meanwhile, the pitching staff fought hard to find the zone all night, ultimately combining to throw ninety-nine strikes in a grinding effort on the mound.

This season, a couple of key power hitters have really carried the load for this offense. Left fielder Jordan Walker has been the undisputed home run king for the club this year, leading the roster with an impressive twenty-nine home runs. Right on his heels is the incredibly versatile Alec Burleson, who has slugged his way into second place on the team with twenty-five home runs of his own. Burleson hasn't just been a power threat, though; he has been the absolute engine of this offense. He leads the Cardinals in both run production and pure hitting, racking up an exceptional one hundred fifteen RBIs alongside a team-high .280 batting average. On the defensive side of the ball, the pitching and fielding units have actually kept things relatively tight, surrendering a respectable average of just 3.2 runs over their last five games. As they prepare to take the field one last time, the Cardinals are desperate to put these recent struggles behind them, tighten up their play, and finish the year on a high note.

Key Stats

• St. Louis’ Alec Burleson this season: 25 HRs, 115 RBI, .280 AVG
• Milwaukee’s Jackson Chourio this season: 25 HRs, 72 RBI, .286 AVG

Betting Odds & Market Overview:

• MIL -238 / STL +193; O/U 7

St. Louis vs. Milwaukee Picks and Prediction

The Brewers have already wrapped up the No. 1 seed for the playoffs, so there isn’t much left for them to prove in the regular season. For the Cardinals, though, Sunday marks the end of the road, and they’ll be looking to close out a disappointing year on a positive note with one last win. St. Louis will turn to Andre Pallante, who comes in with a 12-8 record and a 3.61 ERA. Milwaukee will counter with Jacob Misiorowski, who has been excellent this season, going 15-5 with a 1.86 ERA. Final Score Prediction, Milwaukee Brewers win 3-2.