St. Louis Cardinals vs. Milwaukee Brewers Prediction and Picks - September 12, 2025
The St. Louis Cardinals face the Milwaukee Brewers with both teams heading in opposite directions to close out the season. The Cardinals are 72-75, and with three losses in a row, they have the second-worst record in the National League Central Division. The Brewers are 89-58 and have the best record in baseball. Who will win this game? Check out our Cardinals vs Brewers prediction!
When it comes to MLB picks, our MLB Predictions are stellar.
Sign Up for Winners and Whiners News Alerts, Get Free Picks and Discounts
Subscribe Now
St. Louis hopes Pallante and lineup step up
The Cardinals are having a season to forget and look poised to miss the postseason for the third season in a row. Andre Pallante will start the upcoming game and he looks to improve on what’s been a rough season on the mound as he’s allowed 95 runs in 150 innings pitched. Additionally, with a .267 expected opponent Batting Average, a 15.9 Strikeout Percentage, and a 4.27 expected ERA, opponents are making contact and driving in runs at will against Pallante this season.
Pallante has struggled but the lineup has let the Cardinals down this season, scoring only 4.28 runs per game with only seven runs in the last three games. Ivan Herrera is slashing .279/.363/.450 with 15 home runs and 150 total bases while Willson Contreras is slashing .253/.337/.444 with 20 home runs and 214 total bases but the rest of the lineup has struggled. Only four batters have an OPS+ over 100, and opposing pitchers can limit the top-heavy lineup as a result.
Brewers hope Priester and lineup carry them
The Brewers are having a great season and look to secure the best record in baseball down the stretch. Quinn Priester will start the upcoming game, and he looks to build on a strong season as he’s allowed only 55 runs in 151 innings pitched while tossing 113 strikeouts. Moreover, with a .384 expected opponent Slugging Percentage, a 6.9 Barrel Percentage, and a 3.71 expected ERA, opponents are making weak contact off the bat and struggling to drive in runs against Priester this season.
Priester has stepped up but the lineup is one of the best in the majors, scoring 5.05 runs per game. Christian Yelich is slashing .267/.348/.460 with 27 home runs and 236 total bases while Isaac Collins is slashing .272/.370/.428 with 148 total bases but the rest of the lineup has also been great. Brice Turang is slashing .289/.356/.445 with 18 home runs and 237 total bases while Jackson Chourio and William Contreras have added 37 home runs and 453 total bases to round out the lineup, making the Brewers tough to put away at the plate.
Cardinals vs Brewers Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Spread Pick for Cardinals vs. Brewers
- Brewers (-170) (4 Units)
The Brewers have stumbled lately but they are one of the best teams in baseball and look to step up and take over this game from the first inning. The Brewers, who average 5.05 runs per game, should drive in runs at will with Christian Yelich, Brice Turang, and the rest of the lineup making contact and putting together strong plate appearances. The Brewers should limit a Cardinals lineup that averages only 4.28 runs per game with Quinn Priester stepping up on the mound and tossing multiple strong innings to hand the ball over to the bullpen with the lead. The Brewers should win the game with a strong performance at home.
Take the Brewers money line as home Favorites.
Total Pick for Cardinals vs. Brewers
- Under 8.5 (5 Units)
The Brewers have one of their best pitchers on the mound and this game looks to be a low-scoring one from the first pitch. The Cardinals should limit the Brewers' lineup with Andre Pallante stepping up on the mound and tossing multiple strong innings. The Brewers should eliminate and potentially shut out the Cardinals, who have scored only seven runs in their last three games, with Quinn Priester, who has allowed only 55 runs in 151 innings pitched, tossing multiple scoreless innings with minimal contact and a surplus of strikeouts. The Under should cover in a low-scoring game with both starting pitchers stepping up.
- Take the Under on 8.5 runs.
The Cardinals face the Brewers with both teams heading in opposite directions to close out the season.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $150
